471 RESULTS
Sort By:
At AAIC, updated imaging data in autosomal-dominant AD shows that longitudinal MRI in large numbers of people confirms atrophy patterns. Tau PET is more variable in DIAN participants than in the Colombian families.
As data pours in, DIAN leaders strive to share and publish it without accidentally disclosing mutation status. The more is learned about preclinical AD, the harder this may get.
Researchers at AAIC presented congruent data on the place tau tangles take in AD progression, and their close correlation with cognitive decline.
Researchers at AAIC proposed several different measures of brain connectivity that may predict progression to AD.
Preserved brain networks may explain the exceptional memory prowess of some older adults.
In Italian memory clinics, the PET scans resulted in diagnosis and medication changes for up to a third of patients.
Two international initiatives compile metadata from aging and AD studies into huge searchable catalogs in hopes of speeding research progress.
Before any other changes, the fatty coating on peripheral nerve fibers breaks apart, heralding their degeneration.
Researchers at SfN 2016 reported that oligomeric and exosomal forms in plasma predict AD as early as a decade prior to symptoms.
Cognitively normal people who harbor plaques in their brains are more likely to report feelings of isolation.
Methods that trawl body fluids for amyloidogenic proteins are getting more sensitive and specific, and scientists are expanding the repertoire of oligomers they can detect.
Diurnal variations disappear as less Aβ42 reaches cerebrospinal fluid. Findings may improve timing of daily amyloid treatments.
Convened by ARUK to learn from the antibody’s billion-dollar bust, industry and academic leaders declare insufficient CNS target engagement, say peripheral sink did not work, and brainstorm how to move forward.
In the field’s march toward automated testing, scientists for the first time used biomarker cutoffs determined in one cohort to predict amyloid accumulation in a second. It worked.
People with ALS—especially those who progress fast—express myriad inflammatory genes in their blood monocytes.
