TREM2 Goes Up in Spinal Fluid in Early Alzheimer’s
TREM2 levels tracked with tau, but varied widely among patients and carriers of different mutations, leaving it unclear whether TREM2 helps or hurts.
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TREM2 Tidbits at AAIC: Genetics, Clinical Data
Probing this this Alzheimer’s risk factor, scientists find a novel variant, but no consensus yet on how this cell surface receptor increases risk for disease.
Structure of Microglial Receptor Offers Clues for PET Ligand Design
For the first time, scientists report a crystal structure of TSPO, a potential target for PET imaging of neuroinflammation.
WANTED: Biomarkers for Drug Trials in Frontotemporal Dementia
Hoping for better luck in clinical trials than their Alzheimer’s colleagues had in the past decade, FTD researchers are now chasing biomarkers. It’s slim pickings so far, but neurofilament, tau PET, and MRI are showing promise.
Meta-Analysis of 21 Years of Alzheimer's Fluid Biomarker Research
Study improves confidence in three core biomarkers and five emerging markers, most in cerebrospinal fluid and one in blood.
Biomarkers Differentiate Parkinsonian Diseases and Forecast Decline
Can proteins in the cerebrospinal fluid help tell movement disorders apart and predict who will develop dementia?
Keystone: Diagnosis and Model Treatments for Traumatic Brain Injury
Identifying injuries that might lead to chronic traumatic encephalopathy or other neurodegenerative pathologies, and then treating those injuries, are two major challenges...
Biomarker Progress? Picking the New, Better Measuring the Old
Individual labs are experimenting trying to improve the differential diagnoses of related dementias...
Do African-Americans Have More, or Different, Alzheimer’s Disease? Too Little Data to Tell
At a workshop on engaging more black Americans in ADRD research, new CSF findings stood out against a general dearth of data on Alzheimer’s disease in underrepresented minorities.
Alzheimer’s Researchers Seek Advice on How to Include African-Americans
Despite having a higher incidence of Alzheimer’s or a related dementia, relatively few black people participate in research studies or drug trials. How to achieve full representation?
NfL in Blood Foretells Poor Brain Health After the Heart Stops
Neurofilament light protein in the serum registers the degree of axonal damage after cardiac arrest, and may help doctors predict long-term consequences for the brain.
It’s Official: Tau PET Sees Tangles, and Staging Tangles Predicts Decline
Scientists at CTAD were excited about postmortem validation of tau scans and new, more sensitive tracers. Others are exploring practical applications for live imaging of tau pathology.
Amyloid PET Aids Diagnosis. But Could CSF Do Just as Well?
Large IDEAS data set establishes that PET scans are valuable in clinical practice. Other studies suggest CSF biomarker ratios perform nearly as well.
Is NfL the New 'N' in A/T/N Classification of Alzheimer’s?
People with a lot of neurofilament light protein in their spinal fluid are more likely to develop mild cognitive impairment in the next four years.
Progranulin: A Mark of Worsening Alzheimer’s?
In sporadic and familial forms of AD, progranulin climbs in the cerebrospinal fluid as disease progresses, perhaps reflecting microglial activation.