Amyloid-PET Results Lead Some to Ponder Assisted Death in Future
In a research study, one-fifth of healthy people who learned they were at high risk for AD said they might consider physician-assisted death as a future option.
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Plasma NfL Goes the Distance in Alzheimer’s
In ADNI, blood marker exposes ongoing neurodegeneration across disease stages.
ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s
Scientists know that the retina changes in people with preclinical AD; alas, there is neither consensus nor convergence in the field of retinal imaging. An upcoming initiative aims to determine which measures are most robust.
Spitting, Sniffing: Is This How We Will Dx Parkinson’s?
Scientists are probing saliva and skin secretions for telltale signs of Parkinson’s disease. Their prize? A diagnostic test at the pre-motor stage.
New Money to Spur Tech Search for AD Biomarkers
Diagnostics Accelerator to fund projects that develop dementia biomarkers from patient data.
Electrode Detects Aβ Aggregates in Alzheimer’s Plasma
The method purportedly distinguishes patients from controls with more than 90 percent sensitivity and specificity.
Results from IDEAS Study Published
A majority of amyloid PET scans led physicians to change how they managed a patient’s disease. The effect on later outcomes is yet to be come.
NIH Summit Sets Agenda for AD-Related Dementias
Among 20 focus areas, 47 research recommendations cover the gamut from basic science to health disparities.
Deep Blue for Aβ Blood Test?
IBM researchers in Australia identify a combination of four proteins in plasma that predicts amyloid positivity in cerebrospinal fluid, and correlates with progression to AD.
Midlife Peripheral Inflammation May Drive Later Cognitive Decline
A longitudinal study finds that middle-aged people with the highest levels of inflammation markers in their blood succumb to the greatest cognitive decline over the next 20 years.
Is a Woman’s Brain More Susceptible to Tau Pathology?
Among cognitively normal people with amyloid plaques, women have more tau tangles in the entorhinal cortex than do men. Does this indicate susceptibility, or resilience?
Panel of Blood Markers Signals Amyloid in Brain
In cognitively normal people, a set of blood proteins may predict whether or not amyloid plaques have deposited in a person’s brain.
Blood Test Granted Breakthrough Status, To Be Tested in Trial
The FDA has prioritized review of C2N’s blood test for amyloid-β. A pivotal clinical trial will correlate the test with amyloid PET scans.
Another Reason to Catch Some Zzzs: Sleep Regulates Tau Release
Studies in mice and humans show that sleep suppresses extracellular tau and slows its spread.
Neurofilament in Blood Foretells Early Onset Alzheimer’s
In familial Alzheimer’s disease, rise in NfL in the blood precedes disease onset by 16 years.
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