Flortaucipir Meets Primary Endpoints in Phase 3 Autopsy Trial
PET tracer predicts tau pathology and AD, according to company press release.
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Does Retinal Thinning Reflect Early Alzheimer’s?
Study links changes in the retina’s microvasculature to brain amyloid in cognitively normal adults.
For the Faint of Heart: Doc, Want to Check Their NfL?
What's the use of measuring neurofilament light in blood? The marker could help with AD trial enrollment and measuring drug effects. It could even guide brain-sparing improvements in heart surgery, say researchers at AAIC 18.
Blood Test for Neurofilament Light Chain Kicks Up Biomarker Research
With buckets of new data at AAIC, blood NfL grabbed attention as a telltale of neurodegeneration. The protein predicts progression, and might one day track treatment effects.
With Sudden Progress, Blood Aβ Rivals PET at Detecting Amyloid
At AAIC, competitors vied for advantage, and discussion moved swiftly to the issue of assay standardization.
Memory Slips as Soon as Amyloid Appears, Two Decades Before Dementia
Sensitive cognitive tests detect deficits in preclinical Alzheimer’s even before an amyloid scan reads positive. And CSF Aβ42 drops a decade before that—pushing research ever farther into the preclinical phase.
Thinning Retina … Could It Be Parkinson’s?
In early Parkinson’s disease, sparse areas on the retina correlate with dying dopaminergic neurons in the substantia nigra.
PET Ligand Lights Up AAIC, May Detect Synapse Loss in AD
UCB-J hints at early synaptic loss in the hippocampus, but not the cortex. Researchers puzzle over the pattern.
$30 Million Venture Philanthropy Project for AD Biomarkers
Investors pledge new money for research into biomarkers that yield marketable tests.
For One in Four Memory Clinic Patients, Amyloid-PET Changes the Diagnosis
In an unselected cohort, amyloid-PET scans changed clinical diagnoses and treatment plans for a quarter of participants.
Bad Synergy—Together, Vascular Problems and Aβ Hasten Memory Slippage
High vascular risk scores and Aβ burden independently associate with cognitive decline, but combined, they speed things up.
Study Finds Sex Influences CSF Tau Levels in ApoE4 Carriers
ApoE4 raises CSF tau more in women than in men, suggesting sex may influence the risk of neurodegeneration, especially in amyloid-positive E4 carriers.
New Definition of Alzheimer’s Hinges on Biology, Not Symptoms
For the first time, NIA-AA proposal bases diagnosis in living people solely on biomarkers for plaques and tangles.
Is Shape of Aβ an Early Blood Biomarker for Alzheimer’s?
An infrared spectral signature of amyloid β-sheets predicted AD conversion years before diagnosis.
News From the PET Front: Early Amyloid Networks and Tau Mystery
At AAT-AD/PD, scientists showed that correlated amyloid patches are an even earlier marker than brain-wide positivity, while others puzzled over why tau signals are lower in older people.
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