Tau, More than Aβ, Affects Sleep Early in Alzheimer’s
During deep sleep, people with AD pathology, particularly tau tangles, have less low-frequency slow-wave brain activity, which is important for memory consolidation.
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Do Alzheimer’s Biomarkers Vary by Race?
The largest study so far to compare brain scans and CSF among African-Americans and Caucasians finds differences, but participant numbers remain small.
New PET Tracer Selectively Lights Up Activated Microglia in Brain
The ligand binds the microglia-specific CSF1 receptor in animal and postmortem studies; human trials are forthcoming.
2018—A Year in Research
This past year, therapeutic antibodies massively reduced brain amyloid, blood tests came into their own, and systems-based approaches transformed the study of gene expression, glial cells, and selective vulnerability.
Could a Blood Test for Tau Diagnose Alzheimer’s Disease?
An ultrasensitive assay picked up elevated concentrations of N-terminal tau fragments in the blood of people with AD.
Autopsy Study Confirms Flortaucipir PET Lights Up Tau Pathology
Case study in early onset AD finds PET ligand tracks regional tau burden.
Neurofilament Light: A Universal Mark of Neurodegeneration
In patients across a range of neurodegenerative diseases, NfL ramps up in the cerebrospinal fluid. Levels are higher in those with worse disease.
Imaging Data Resurrects Abandoned Parkinson’s Gene Therapy
FDG PET revealed the formation of a new functional brain network. It explains clinical improvements noted previously.
Progranulin: A Mark of Worsening Alzheimer’s?
In sporadic and familial forms of AD, progranulin climbs in the cerebrospinal fluid as disease progresses, perhaps reflecting microglial activation.
How Does The NIA-AA Framework Measure Up Against Real Data?
Researchers are applying the proposed 2018 NIA-AA diagnostic criteria to three large, standing cohorts. How did the research framework perform?
Is NfL the New 'N' in A/T/N Classification of Alzheimer’s?
People with a lot of neurofilament light protein in their spinal fluid are more likely to develop mild cognitive impairment in the next four years.
Amyloid PET Aids Diagnosis. But Could CSF Do Just as Well?
Large IDEAS data set establishes that PET scans are valuable in clinical practice. Other studies suggest CSF biomarker ratios perform nearly as well.
It’s Official: Tau PET Sees Tangles, and Staging Tangles Predicts Decline
Scientists at CTAD were excited about postmortem validation of tau scans and new, more sensitive tracers. Others are exploring practical applications for live imaging of tau pathology.
Blood Tests for Amyloid Step Out at CTAD
With plasma tests performing in AIBL staging, scientists are sharing data across platforms and cohorts, and tackling standardization to avoid time lost to irreproducibility.
NfL in Blood Foretells Poor Brain Health After the Heart Stops
Neurofilament light protein in the serum registers the degree of axonal damage after cardiac arrest, and may help doctors predict long-term consequences for the brain.
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