Testosterone Therapy for Men with Alzheimer Disease?
For years, postmenopausal women have agonized over the risks and benefits of estrogen replacement therapy. Now comes a hint that elderly men might benefit...
ALL NEWS
6397 RESULTS
Sort By:
Add Mental Exercise to Potential AD Protection
Evidence is accumulating that certain activities are correlated with a reduced risk of Alzheimer's disease, though whether this relationship is one of cause and effect is still open to debate. Recent articles have demonstrated this link...
SfN: Return of the Other—Tau Is Back, Part 1
This year’s 35th annual meeting of the Society for Neuroscience had groups of researchers share a common sense of excitement about...
How Now, Phospho-tau? Sparing Synapses, Messing with Microtubules
Just where in the pathogenic process tau deals cells their death blow is a topic of much debate and research. Two studies published this week take a closer look. Brandt et al. report on the effects of a pseudohyperphosphorylated tau mutant in hippocampal slice cultures...
The Unkindest Cut: Caspase-6 Cleavage of Huntingtin Produces Killer Fragment
Expansion of the polyglutamine (polyQ) tract in the huntingtin protein is necessary to cause Huntington disease, but it is not...
Ataxia Proteins Tied Together in Disease-related Interactome
Cerebellar ataxias form a large group of movement and balance disorders that result from degeneration of Purkinje cells...
Polyglutamine Disease Therapy—Bypass the Glutamine?
Papers in tomorrow’s Cell and last week's Neuron reveal that protein phosphorylation plays a key role in spinocerebellar ataxia type 1 (SCA-1), an ultimately fatal neurodegenerative disease marked by progressive loss of muscle control...
Inclusions: Part of the Problem, or the Solution?
The appearance of clots of abnormal proteins inside neurons is characteristic of...
CSF Biomarkers—Maybe You Can See the Forest for the Trees
The prospects of using cerebrospinal fluid biomarkers to diagnose Alzheimer disease may have just gotten a bit brighter...
Diagnosis of AD—Does Spinal Fluid Hold the Key?
In this week's Journal of the American Medical Association, researchers report a correlation between Alzheimer's disease (AD) and the appearance in the cerebrospinal fluid (CSF) of two proteins thought to play major roles in the progression of the disease—amyloid β42 (Aβ42) and tau...
Brain Imaging Speaks Volumes about AD and the Aβ Sink
A paradox has plagued Alzheimer disease (AD) researchers for quite some time: People with AD have...
SfN: Early Steps toward Parkinson Disease Blood Test
Biomarkers are the buzz of the field these days, and the hum was heard inside the beltway at the 35th Annual Conference of the Society for Neuroscience...
Looking outside the Brain for Early Signs of AD
The use of gene expression profiling to characterize Alzheimer disease pathology has, unsurprisingly, focused on...
Of Cabbages and Rings—AD and the Vasculature
Two recent reports add to the growing evidence that trouble in the circulatory system can lead to...
DNA Deletions Sap Mitochondria in Parkinson Neurons
Mutations in mitochondrial DNA (mtDNA) accumulate in aging and Alzheimer disease, but their impact on cell physiology...
Current Filters
No filters selected