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The triplet repeat disease X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a polyglutamine expansion in the androgen receptor (AR) gene. Just how this expansion causes degeneration of lower motor neurons...
A paper published online 19 December in Nature Neuroscience takes aim at two omnipresent issues in Alzheimer disease research...
Ever since encephalitis halted development of Elan’s active vaccine for Alzheimer disease...
In today's Science, Cynthia Kenyon and colleagues at the University of California, San Francisco, report that they have generated transgenic nematodes, <em>Caenorhabditis elegans</em>, that live six times longer than normal, the equivalent of about a 500-year lifespan in humans...
Nearly four years ago, Steven Paul and coworkers published a provocative paper that showed...
While the amyloid hypothesis—that aggregates of Aβ peptide are the primary pathogen in AD—drives much of Alzheimer's disease research, it remains controversial...
The MetLife Foundation announced this year’s award winners at a celebration of its...
One of the hallmarks of sporadic Parkinson's disease (PD) are Lewy bodies (LB), neuronal cytoplasmic inclusions that contain ubiquitinated proteins. Recently researchers have focused on two key LB components, the 16 kDa α-synuclein, and the ubiquitin-ligase parkin...
One poster that stood out at last month’s 35th Annual Conference of the Society for Neuroscience was that of...
Part 2 of our report by Minji Kim, Alice Lu, and Rudy Tanzi. Steve Younkin, Mayo Clinic at Jacksonville, Florida, presented the recent progress in identification of...
This is part 3 of our report by Minji Kim, Alice Lu, and Rudy Tanzi. Sam Gandy, Thomas Jefferson University, Philadelphia, reviewed the trafficking pathways of APP from the endoplasmic reticulum (ER) to...
In part 4 of our report, Minji Kim, Alice Lu, and Rudy Tanzi summarize presentations by Dennis Selkoe, Christian Haass, Bart De Strooper, Jie Shen, Homira Behbahani, and Taisuke Tomita...
In part 6 of our Keystone Symposia Meeting summary, Minji Kim, Alice Lu, and Rudy Tanzi relay new developments in tau biology and frontotemporal dementia...
New insights into the role of ApoE, the blood-brain barrier, and degrading enzymes in clearance of Aβ...
The last part of our Keystone Symposia meeting covers the last two sessions on therapeutics...
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