Tall Science at Small Retreat: Dispatch from Germany’s Eibsee
Part 1 of our 11-part conference series.
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Part 1 of our 11-part conference series.
In today’s Science, researchers from the Burnham Institute, La Jolla, California, report a new pathway that can cause neuronal apoptosis, or programmed cell death—the covalent modification of extracellular matrix metalloproteinases (MMPs)....
Oxygen is a double-edge sword for cells: It is necessary for life, but at the same time it is the source of damaging free radicals that attack DNA, proteins and cell membranes...
Who would have thought that nitric oxide (NO) and zinc (Zn+) act in concert to activate apoptosis? That's the conclusion Stuart Lipton and colleagues propose in a report in the February 5 Neuron...
Part 8 of our 11-part Eibsee conference series.
A pair of studies published in the July 6 Neuron show that in two different mouse models of Down syndrome, the cause of neuron death...
Part 9 of our 11-part Eibsee conference series.
Part 10 of our 11-part Eibsee conference series.
Early in the course of Alzheimer disease, blockages in axonal traffic lead to sick axons swollen with the jumbled pile-up of traffic components. The blockages precede...
The tumor suppressor p53 is perhaps best known as a cellular watchdog that prevents cancer by...
Evidence has grown over the last few years for the involvement of the tumor suppressor protein p53 in the neuronal cell death that accompanies a variety of neurodegenerative diseases, including Alzheimer's disease...
The tumor suppressor p53 appears to play a role in the pathogenesis of rheumatoid arthritis. What about Alzheimer's disease?
A mixed bag of epidemiologic studies alternatively hold up and knock down the promise that...
After their production in endosomes, intraneuronal membrane-bound amyloid-β (Aβ) accumulates in multivesicular bodies (MVBs), but...
This is part 2 of our 3-part series.
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