BACE RNAi Scores in Mouse Model of AD
Among the strategies currently being pursued for treatment of Alzheimer disease (AD), inhibiting...
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Among the strategies currently being pursued for treatment of Alzheimer disease (AD), inhibiting...
Embryonic or pluripotent stem cells remain one of the best hopes for replacing the lost or damaged tissue that can lead to neurodegenerative diseases...
For years, geneticists studying tau have been stymied by the conspicuous absence of...
Hunting for clues to the function of the Parkinson gene DJ-1, researchers have garnered new leads by once again...
Though most neurodegenerative diseases affect different parts of the brain, the presence of...
In August 2005, a group of researchers from inside and outside the field of Alzheimer disease met in Bar Harbor, Maine, with foundation and NIH representatives for two days of presentations and discussion at the fifth annual workshop on Enabling Technologies for Alzheimer's Disease Research.
It is widely accepted that at least a fraction of APP is actively transported along the axon to the nerve terminal and does not return to the cell body.
After release, some Aβ is degraded locally, a second fraction leaves the brain through interstitial fluid drainage and along brain arterioles, while another fraction is actively transported by proteins, such as LRP and glycoprotein-P, across the blood-brain barrier (BBB) into systemic circulation.
Clearly, the greatest risk factor for AD is advanced age, but a satisfying explanation of the link between aging and AD remains uncertain. To understand this connection, it is argued that a better understanding of "normal" aging is needed.
This workshop has an enduring interest in facilitating the import into AD research of new technologies developed in other areas. This year an approach was presented that makes it possible to watch neurons grow and change over time inside living mice.
Recommendations for future research following the Enabling Technologies for Alzheimer's Disease Workshop in Bar Harbor, ME
APP Function: A Report from Bar Harbor APP and Axonal Transport: A Report from Bar Harbor BBB/Brain Vasculature: A Report from Bar Harbor Aging and AD: A Report from Bar Harbor Enabling Technologies: A Report from Bar Harbor Recommendations: A Report from
Researchers from the labs of William Klein and Richard Van Duyne at Northwestern University in Chicago have developed a new, highly sensitive...
This week, a study previously reported in our Conference News appeared in PNAS. In it...
Can a heart disease lab advance our understanding of neurodegeneration? It can, it turns out, at least when it comes to...
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