Paper Alert: Intranasal Insulin Data Fuels Push for Phase 2B Trial
cognitive and functional tests, as well as CSF biomarker and imaging endpoints, she told ARF.—Esther
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Evidence Piles Up for Lysosomal Dysfunction in Parkinson’s
story).—Esther Landhuis None http://www.alzforum.org/new/detail.asp?id=3172 Parkinson's Disease Proteostasis
New Substrate for Parkinson’s Protein Is Picky About Phosphate
said.—Esther Landhuis None http://www.alzforum.org/new/detail.asp?id=3286 Parkinson's Disease LRRK2
DC: Developing But Debatable—Deacetylase Inhibitors for CNS Disease?
and probably a lot safer,” she told ARF.—Esther Landhuis. This is Part 2 of a two-part series. See also Part 1.
Bad Guys—Aβ Oligomers Live Up to Reputation in Human Studies
story; Gandy et al., 2010).—Esther Landhuis None http://www.alzforum.org/new/detail.asp?id=2439
Multimodal Imaging: Structure, Function, Amyloid Not in Synch
white matter change through a CAA route.—Esther Landhuis None
Chicago: Does Saying “I Do” Lower Late-life Dementia Risk?
event that, if sustained, seems to add to the AD risk conferred by the ApoE4 gene.—Esther Landhuis. None
ApoE4 Promotes Aβ Oligomerization
to be lipidated to achieve that remains unclear.—Esther Landhuis None
Déjà Vu? AD Patients Again Look Worse on γ-Secretase Inhibitor
conference story).—Esther Landhuis. Reference: Coric V, van Dyck CH, Salloway S, Andreasen N, Brody M,
CSF Biomarkers Track With Atrophy, Cognition in Normal Aging
fit into the pathogenic process (Jack et al., 2010 and ARF Live Discussion).—Esther Landhuis None
Paper Alert: In Vivo Human Data Shows Reduced Aβ Clearance in AD
or a combined increase in Aβ production with impaired efflux from parenchyma to CSF,” they noted.—Esther
Amyloid Imaging: Laying PIB Concerns to Rest
a drug…that’s a drop in the bucket.”—Esther Landhuis Esther Landhuis is a science journalist in Dublin,
AD Research Participation: Patients Want to Know
compounds, showed they were having a silent heart attack.—Esther Landhuis None
Chew the Fat—Lipids, NMDARs Mediate Neuronal Response to Aβ
the mechanisms involved.”—Esther Landhuis None http://www.alzforum.org/new/detail.asp?id=2292 Alzheimer's
NO Kidding? Mitochondria Fission Protein Linked to Neurodegeneration
of other AD drug candidates, Lipton said.—Esther Landhuis None