All Comments by David Holtzman

  1. Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide.
  2. The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration.
  3. Mutant Proteins—Is it Quality or Quantity that Counts?
  4. Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation.
  5. Local and systemic increase in lipid peroxidation after moderate experimental traumatic brain injury.
  6. Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.
  7. Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment.
  8. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis.
  9. Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.
  10. Want to Keep Your DNA in Good Repair? Then Eat Your Spinach!
  11. Neurons Need Cholesterol from Glia to Make Synapses
  12. A Kinder, Gentler Alzheimer's Vaccine?