All Comments by Jürgen Götz

  1. Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.
  2. Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease-Like Pathology and Cognitive Decline in Aged 3xTgAD Mice.
  3. Neuronal mRNAs travel singly into dendrites.
  4. Pinning Down Role for Tau Proline Isomers in Alzheimer’s
  5. Extracting β-amyloid from Alzheimer's disease.
  6. Atomic identification of fluorescent Q-dots on tau-positive fibrils in 3D-reconstructed pick bodies.
  7. Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations.
  8. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.
  9. Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.
  10. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.
  11. Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
  12. The Plot Thickens: The Complicated Relationship of Tau and Aβ
  13. The Alzheimer's disease mitochondrial cascade hypothesis.
  14. Caspase activation precedes and leads to tangles.
  15. Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein.