All Comments by Hiroshi Mori
- The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide.
- Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease.
- Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1.
- Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage.
- alpha-Synuclein membrane interactions and lipid specificity.
- Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.
- Protein anatomy: C-tail region of human tau protein as a crucial structural element in Alzheimer's paired helical filament formation in vitro.
- Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.
- Cerebrospinal fluid tau protein as a biochemical marker for Alzheimer's disease: a community based follow up study.
- A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
- Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.
- Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.
- Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.
- Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients.
- Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red.