All Comments by Hiroshi Mori

  1. The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide.
  2. Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease.
  3. Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1.
  4. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage.
  5. alpha-Synuclein membrane interactions and lipid specificity.
  6. Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.
  7. Protein anatomy: C-tail region of human tau protein as a crucial structural element in Alzheimer's paired helical filament formation in vitro.
  8. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.
  9. Cerebrospinal fluid tau protein as a biochemical marker for Alzheimer's disease: a community based follow up study.
  10. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
  11. Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.
  12. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.
  13. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.
  14. Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients.
  15. Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red.