All Comments by Edward Koo

  1. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
  2. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
  3. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
  4. Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice.
  5. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.
  6. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
  7. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
  8. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
  9. Volumetric MRI study of the caudate nucleus in patients with dementia with Lewy bodies, Alzheimer's disease, and vascular dementia.
  10. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
  11. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.
  12. Imaging hippocampal function across the human life span: is memory decline normal or not?
  13. Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
  14. Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.
  15. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.