All Comments by Edward Koo

  1. Caspase-cleaved amyloid precursor protein in Alzheimer's disease.
  2. NACP/alpha-synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases.
  3. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
  4. Serum insulin-like growth factor I regulates brain amyloid-beta levels.
  5. Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide.
  6. Assessment of low-flow CSF drainage as a treatment for AD: results of a randomized pilot study.
  7. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
  8. Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
  9. Alzheimer's disease can be accurately diagnosed in very mildly impaired individuals.
  10. Rates of progression in mild cognitive impairment and early Alzheimer's disease.
  11. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
  12. Alzheimer's second patient: Johann F. and his family.
  13. Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.
  14. Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
  15. Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.