All Comments by Benjamin Wolozin

  1. Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.
  2. Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice.
  3. Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity.
  4. Presenilins are not required for A beta 42 production in the early secretory pathway.
  5. Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.
  6. Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy.
  7. Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis.
  8. Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.
  9. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
  10. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.
  11. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.
  12. Chaperone-like activity of synucleins.
  13. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
  14. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study.
  15. Another Not-Quite-Parkinson's Model