Chimeric Protein Dephosphorylates Tau, Improves Memory
In tauopathy mice, a peptide construct recruited protein phosphatase 1 to tau. Dephosphorylation lowered total tau, restoring synaptic density and memory.
NEWS
Single-Cell Methylomes Offer Clues to Aging
In mouse brain, mRNA methylation distinguishes cell subtypes and changes with age. One standout: APP. It loses its methyls with age.
Oligodendrocytes Pump Out Aβ42, Exacerbating Plaques and Synaptotoxicity
Three new papers report these myelin-producing cells contribute up to a third of plaque Aβ in transgenic mice.
CSF Proteins Spot Alzheimer’s Mutation Carriers Decades Before Symptoms
A CSF proteomics study in ADAD mutation carriers identified 137 potential markers. They span the AD continuum. For 12 of them, their concentrations change prior to those of classic AD biomarkers.
New Alzheimer’s Gene? Cytochrome P450 Protein Linked to Tangles
In a tau PET GWAS, a SNP linked to higher expression of the oxidizing enzyme was associated with more cortical tangles.
Synaptic Skirmish: Aβ and Tau Pathologies Battle Over Brain Rhythms
Plaques rev up neural oscillations, while tangles turn them down, ultimately leading to sluggish synapses. The slowdown foreshadows symptoms.
Glial Cell Communities Conspire to Drive Alzheimer’s Disease
Transcriptomes of more than 400 postmortem brains reveal microglia and astrocyte subtypes that collaborate to precipitate pathologic changes.
X-Chromosome-Wide Association Data Spot Alzheimer’s Loci
XWAS from three research groups identified a dozen genetic loci that may help explain sex differences in AD.
SPOTLIGHT
Glial Cell Communities Conspire to Drive Alzheimer’s Disease
Where in the amyloid cascade does inflammation fit? Everywhere, according to a new snRNA-Seq study of more than 400 postmortem brains. The authors identified one microglial subtype that promotes plaques, another that promotes tangles, and an astrocyte subtype that contributes to cognitive decline. Intriguingly, in brains with plaques but few tangles, a different set of glial subtypes predominated. The data add to the evidence that AD has a cellular phase.
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