Do Immune Cells in the Meninges Help with … Memory?
Resident T cells in the membrane surrounding the healthy mouse brain influence both short-term memory and synaptic plasticity.
NEWS
TOM1: A Check on Runaway Inflammation in Alzheimer’s?
The protein helps internalize neuronal interleukin receptors. It also promotes microglial phagocytosis. Does its absence worsen neuroinflammation and Aβ burden?
It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
Researchers induced cortical organoids to grow their own vasculature and even form a blood-“brain” barrier, making the little blobs more useful for studying disease.
Adenosine Receptors Rev Up Immune Response, Memory Loss, in Tau Model
Overexpressing neuronal A2A receptors stoked C1q in microglia, damaging synapses and memory.
Mysterious RNA Circles Crop up in Alzheimer’s Brain
The circular transcripts correlate with AD pathology and dementia severity, suggesting potential roles in pathogenesis or as biomarkers.
Amyloid—It’s Not Whether, but for How Long You’ve Had It
A new study argues that the duration of a person’s amyloid positivity predicts whether they’ll develop tau accumulation and cognitive decline.
MRI and Machine Learning Depict Brain Aging in Health, Disease
From more than 45,000 MRI scans, a typical pattern of brain aging emerges. Brains “age” faster in people who have a neurological disorder.
Anti-Agitation Drug Comes Up Short in Phase 3
Negative findings for AVP-786 belie positive findings from a separate Phase 3 trial announced earlier this year.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Dash Genomics, Inc., Abcam, BrainXell, and the Jackson Laboratory.
SPOTLIGHT
It Bleeds! New Mini-Brain Sports Functioning Blood Vessels
Pea-sized clumps of cortical cells grown in a dish mimic some aspects of the brain, but without a vascular system, neurons inside these organoids get sick and die. Now, scientists have found a way to encourage blood vessels to grow in these little blobs, which keeps the neurons healthy for months. Conveniently, cells lining the vessels form tight junctions, similar to those of the blood-brain barrier. The vascularized organoids could enable in vitro study of barrier function, researchers believe.
Mysterious RNA Circles Crop up in Alzheimer’s Disease Brain
In the crazy world of regulatory RNA, nothing seems more puzzling than circular transcripts. These stable loops have mostly been studied in cancer, but in this week’s Nature Neuroscience, scientists at Washington University report that some circular RNAs correlate with Alzheimer’s disease pathology and clinical severity. The findings hint at potential biomarkers or even therapeutic targets.
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