New Data Questions Herpes-Alzheimer’s Connection
A large multinational epidemiology study finds only small and inconsistent associations.
NEWS
Myeloid Metabolic Crisis May Trigger Cognitive Decline in Aging Brain
Aging macrophages and microglia poorly burn glucose and enter an inflammatory state. Revving their metabolism preserved synapses and memory in mice. What does prostaglandin have to do with it?
Selective Vulnerability News: RORB Neurons Are First Victims of Tangles
By tracing the transcriptomes of neurons that wither early and late in the course of Alzheimer’s disease, researchers peg subpopulations of excitatory neurons in entorhinal cortex as selectively vulnerable to tau. Reactive astrocytes aid and abet.
Plasma P-Tau181 Predicts, Monitors Alzheimer’s Progression
The blood-based marker may be far more scalable and cost-effective for tracking the disease than PET imaging and CSF biomarkers.
Do Lysosomes Help Propagate Tau Seeds?
In cultured cells, lysosomal activity was necessary to enable tau seeds to break out of internalized exosomes and trigger the aggregation of tau in the cytosol.
Expression Analysis Uncovers Three Distinct Forms of Alzheimer’s
High amyloid burden and neuroinflammation, neuronal excitability, and tangles and oligodendrocyte loss distinguish the disease types.
In Phase 2, Donanemab Curbs Cognitive Decline in Early Alzheimer’s
Among people with early AD, the monoclonal antibody wiped out Aβ plaques and slowed cognitive and functional decline by a third, relative to placebo.
Doubling Rab5 in Mice Leads to Neurodegeneration—Without Plaques
Overexpressing the endosomal activator in neurons not only caused those organelles to swell, but also bungled synaptic transmission, goaded hyperphosphorylation of tau, and destroyed cholinergic neurons.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Abcam, BrainXell, and the Jackson Laboratory.
SPOTLIGHT
Do Broken Lysosomes Spill Tau Seeds?
Tiny vesicles known as exosomes ferry aggregated tau between cells, helping to spread pathology. But how does their cargo escape? Ironically, the key lies in the robustness of exosomes, according to a new study. Once internalized, they end up inside lysosomes, which struggle to break them down. In the process, the lysosome makes more acid and ruptures, spilling tau seeds into the cytosol where they trigger new deposits.
Join The Conversation
Professional Resources
New in last 7 days
-
Grants
- New Items: 1
- Total Items: 172
-
Jobs
- New Items: 4
- Total Items: 79
-
Conference Calendar
- New Items: 7
- Total Items: 81
- Member Directory
Latest Comments