As mice age, a busy receptor-mediated protein transport across the barrier wanes; inhibiting an alkaline phosphatase restores it. Meanwhile, the aging barrier becomes generally leaky to large molecules.
Sex-specific polygenic hazard scores predict pathology and cognitive decline.
Cognitive enrichment in early life correlated with less Alzheimer’s pathology, and slower cognitive decline, in late life.
Researchers used PET scans from 4,000 people to link RBFOX1 risk variants to amyloidosis. People with lower RBFOX1 expression in their brains had more amyloid and worse cognition.
Live imaging of mouse brain reveals that microglia quickly engulf cell bodies while astrocytes dispose of the neuron’s more distal reaches. The cleanup crew tires with age.
Alector’s AL002c antibody mobilizes microglia, reduces neuronal dystrophy, and restores normal behavior—all in mice. The clinical version is in Phase 1.
A mouse study claims that the small GTPase restrains pro-inflammatory responses in microglia. Aβ oligomers inhibit RhoA, promoting Aβ deposition and neurodegeneration.
By suppressing a single gene, scientists triggered the transformation of astrocytes into neurons in the mouse substantia nigra, where the converts released dopamine and connected with the striatum.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Dash Genomics, Inc., Abcam, BrainXell, and the Jackson Laboratory.
Here’s a twist: More protein enters young brains than old. In this week’s Nature, researchers describe robust receptor-mediated uptake of plasma proteins in young mice. It’s a perfectly healthy thing. It also falls off steeply with age, but inhibition of a single phosphatase restored brain entry to youthful levels. Could this finding help pharmaceutical strategies to smuggle drugs into aged brains via the transferrin receptor?
It turns out astrocytes aren’t just backup players when it comes to phagocytosis—they have their own job. When researchers triggered cell death in single neurons of living mice, astrocytes gobbled up the degenerating dendritic arbor, while microglia tucked into the soma and proximal dendrites. The two cell types coordinated their actions and respected each other’s territory, like any good team. In aging brain, however, this cleanup crew loses steam.
As the first SARS-Cov-2 infection peak passes in some areas but rises in others, scientists are cautiously resuming lab work and clinical studies, albeit with new safety protocols in place. Regions differ greatly in how fast they can reopen, posing a particular challenge to multicenter, international clinical trials. Madolyn Rogers reported how the reopening is going in different parts of the Alzheimer’s research world. On Tuesday, June 23, the Alzheimer’s Association hosted a webinar with re-opening guidance for clinical research from leading clinicians in India, Spain, and the U.S.
- Benjamin Chapman on Does a Stimulating Childhood Stem Amyloid Plaques in Golden Years?
- Li-Huei Tsai, Joel Blanchard and Adele Bubnys on Blood-Brain Barrier Surprise: Proteins Flood into Young Brain
- Perminder Sachdev on Does a Stimulating Childhood Stem Amyloid Plaques in Golden Years?
- Rachel Buckley on Does a Stimulating Childhood Stem Amyloid Plaques in Golden Years?
- Michael Ewers on Does a Stimulating Childhood Stem Amyloid Plaques in Golden Years?
- Renato Socodato on Does RhoA Rein in Microglial Madness?
- James L. Kirkland on Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons
- Julia TCW on Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons
- Adam Denes on Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons
- Aviva Tolkovsky on Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons
- Emily Button, Elyn Rowe, Tiffany Cameron, Tara Caffrey and Cheryl Wellington on Human Blood-Brain Barrier Model Blames Pericytes for CAA
- Christian Haass, Kai Schlepckow, Kathyrn Monroe and Joseph Lewcock on In Mice, Activating TREM2 Tempers Plaque Toxicity, not Load
- Marco Colonna and Simone Brioschi on Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons
- Ole Isacson on Paper Alert: Astrocytes Convert to Neurons (of the Dopaminergic Persuasion)
- Senthilvelrajan Kaniyappan, Jacek Biernat and Eckhard Mandelkow on Widely Used Tau Seeding Assay Challenged
- Carlo Condello on Tau: Why Alzheimer’s Worsens Fast in Some, Slowly in Others
- Michel Goedert, Suchira Bose and Benjamin Falcon on Tau: Why Alzheimer’s Worsens Fast in Some, Slowly in Others
- Henne Holstege on In the Wake of COVID-19: Trials Interrupted, Delayed, Cancelled
- William Klunk on In the Wake of COVID-19: Trials Interrupted, Delayed, Cancelled
- Chaitra Sathyaprakash on Alzheimer’s Research Restarts, Cautiously
- Nancy Ip on In the Wake of COVID-19: Trials Interrupted, Delayed, Cancelled