The transcriptional repressor quiets neural activity and lengthens lifespan in worms. It is abundant in the brains of cognitively healthy centenarians.
Using chemical cross-linkers to map contacts among amino acids, structural biologists predict that soluble tau is, in fact, a compact globule containing β-sheets poised to snap into a pathological formation.
Ablating the immune cells protected mouse models of frontotemporal dementia from the neurodegeneration caused by human ApoE4.
Resident T cells in the membrane surrounding the healthy mouse brain influence both short-term memory and synaptic plasticity.
The protein helps internalize neuronal interleukin receptors. It also promotes microglial phagocytosis. Does its absence worsen neuroinflammation and Aβ burden?
Researchers induced cortical organoids to grow their own vasculature and even form a blood-“brain” barrier, making the little blobs more useful for studying disease.
Overexpressing neuronal A2A receptors stoked C1q in microglia, damaging synapses and memory.
The circular transcripts correlate with AD pathology and dementia severity, suggesting potential roles in pathogenesis or as biomarkers.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Dash Genomics, Inc., Abcam, BrainXell, and the Jackson Laboratory.
We all know the brain needs rest to age well, but now it turns out it may need REST too. This neuroprotective transcription factor quiets excitatory neuronal activity. Its levels rise in the brain during healthy aging. In roundworms, boosting a REST ortholog lengthened lifespan, while suppressing it shortened life. The data hint that adjusting the balance between excitatory and inhibitory neuronal signaling could help keep the brain young.
Pea-sized clumps of cortical cells grown in a dish mimic some aspects of the brain, but without a vascular system, neurons inside these organoids get sick and die. Now, scientists have found a way to encourage blood vessels to grow in these little blobs, which keeps the neurons healthy for months. Conveniently, cells lining the vessels form tight junctions, similar to those of the blood-brain barrier. The vascularized organoids could enable in vitro study of barrier function, researchers believe.
In the crazy world of regulatory RNA, nothing seems more puzzling than circular transcripts. These stable loops have mostly been studied in cancer, but in this week’s Nature Neuroscience, scientists at Washington University report that some circular RNAs correlate with Alzheimer’s disease pathology and clinical severity. The findings hint at potential biomarkers or even therapeutic targets.
- Li-Huei Tsai on Could Getting Enough REST Extend Your Life?
- Rachel Bennett and Bradley Hyman on In Tauopathy, ApoE Destroys Neurons Via Microglia
- Kwok Im and Terrence Town on Do Immune Cells in the Meninges Help with … Memory?
- Jonathan Kipnis and Kalil Alves de Lima on Do Immune Cells in the Meninges Help with … Memory?
- Shauna Yuan, Walter Low, Timothy O'Brien and Ling Li on It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
- Doo Yeon Kim, Se Hoon Choi and Rudy Tanzi on It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
- Weiming Xia on It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
- Selina Wray, Charlie Arber and Christopher Lovejoy on It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
- Axel Montagne and Mikko Huuskonen on It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
- Li-Huei Tsai and Joel Blanchard on It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
- Anna Orr on Adenosine Receptors Rev Up Immune Response, Memory Loss, in Tau Model
- Huntington Potter on Adenosine Receptors Rev Up Immune Response, Memory Loss, in Tau Model
- Marc Aurel Busche and Carlo Sala Frigerio on Adenosine Receptors Rev Up Immune Response, Memory Loss, in Tau Model
- Michael Woodward on Frontal Metabolic Patterns Mark Behavioral Subtype of AD
- Nilufer Ertekin-Taner on Mysterious RNA Circles Crop up in Alzheimer’s Brain
- Eli Kammerman on LRRK2 Mutation Fires Up Immune Response, Harms Brain
- Rik Ossenkoppele on Amyloid—It’s Not Whether, but for How Long You’ve Had It
- Samuel Lockhart on Amyloid—It’s Not Whether, but for How Long You’ve Had It
- Michele Vendruscolo on Chris Dobson, Master of Protein Folding Research, Dies at 69
- Bruce Yankner on MRI and Machine Learning Depict Brain Aging in Health, Disease
- Mark Cookson on Mitochondrial Jetsam Spurs Neurodegeneration