The field is rapidly building the infrastructure for biomarker studies and large clinical trials.
A U.K. research program developed guidelines for clinical practice. In preliminary studies, it boosted diagnosis and improved patient care.
Using an array of receptors to sense neurons in peril, microglia make matters worse by taking bites out of the struggling cells.
Much of the neuron loss in rTg4510 mice comes from accidental disruptions in mouse genes rather than expression of mutant tau. Pathology spreads quickly in human tau knock-ins.
At Quebec conference, researchers considered multiple aspects of herpesvirus biology that may come in to play in AD.
Injecting α-synuclein fibrils into mouse gut sparked the proteopathic spread of misfolded α-synuclein into the brain, where the aggregates killed dopaminergic neurons and caused motor problems.
Co-sponsors Banner, Novartis, and Amgen announced that they will stop testing CNP520 in two Phase 2/3 studies in people at risk of AD. The drug worsened cognition.
At Quebec conference, human herpesvirus experts devoted a day to consider whether their favorite villain might play a hand in Alzheimer’s pathogenesis.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome Dash Genomics, Inc. and Abcam, which join our other exhibitors — Biogen, BioLegend, BrainXell, NanoString Technologies, and the Jackson Laboratory.
Dementia with Lewy bodies is a devastating disorder, combining some of the worst features of Alzheimer’s and Parkinson’s, but it is relatively rare and often goes unrecognized. DLB research has lagged far behind that for AD and PD, but is rapidly gaining ground. At a recent conference in Las Vegas, researchers discussed worldwide progress in building the infrastructure to support large longitudinal studies and clinical trials for DLB. Researchers presented guidelines for improving diagnosis and management of the disease, and scientists discussed how best to identify prodromal cases for research studies. Read Alzforum’s three-part series.
Might Parkinson’s disease start in the depths of the intestine? A new mouse model provides support for the idea. a-synuclein fibrils injected into the mouse gut seeded the misfolding of normal mouse synuclein there, and the pathology ultimately propagated through the vagus nerve and into the brain. There, it killed dopaminergic neurons and caused a PD-like disease.
In light of recent work implicating human herpesviruses in AD, virologists invited Alzheimer’s researchers to join them at the 11th International Conference on HHV-6 and HHV-7, held last month in Quebec City, Canada. The herpesvirus experts had more questions than AD researchers had answers, but together they started to plot a path toward addressing them. Read our two-part coverage of the meeting.
- Stefan Lichtenthaler on Cognitive Decline Trips Up API Trials of BACE Inhibitor
- Paul Aisen on Cognitive Decline Trips Up API Trials of BACE Inhibitor
- Frances Wiseman and Lennart Mucke on Gene Disruption Haunts Tau Mouse—Knock-Ins Look Promising
- Timothy Hammond and Beth Stevens on Central nervous system regeneration is driven by microglia necroptosis and repopulation.
- Divaker Choubey on Mutations Impair TREM2 Maturation, Processing, and Microglial Phagocytosis
- Eli Kammerman on Going Viral: Alzheimer’s Research at Herpes Conference
- Yunfeng Zheng on Cognitive Decline Trips Up API Trials of BACE Inhibitor
- Eric M. Reiman, Pierre Tariot and Jessica Langbaum on Cognitive Decline Trips Up API Trials of BACE Inhibitor
- Andre Fischer on Long noncoding RNA NEAT1 mediates neuronal histone methylation and age-related memory impairment.
- Stefano Sensi on Aβ Acts Through Pericytes to Throttle Brain Blood Flow
- Bryan Killinger on Forget Fibrils: Lewy Pathology Is More Lipid Than Protein
- Howard Feldman on Settlement Reached Between UCSD and USC, Paul Aisen
- Eef Hogervorst on Prostate Cancer Therapy Makes Dementia More Likely
- Robert W. Williams on Wild Mice Inject Genetic Diversity into Models of Alzheimer’s Disease
- Yaming Wang and Hong Wang on TREM2 function impedes tau seeding in neuritic plaques.
- Bruce Lamb on TREM2 function impedes tau seeding in neuritic plaques.
- John Woulfe on Does Serotonin Pathology Foreshadow Parkinson’s Disease?
- Brad Friedman on Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microglia
- Jaime Grutzendler on Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microglia
- Shane Liddelow on Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microglia
- Li-Huei Tsai and Joel Blanchard on Aβ Acts Through Pericytes to Throttle Brain Blood Flow