In cell culture, slashing Aβ production by more than half harmed neuronal signaling, but a smaller cut maintained it.
Researchers identify a way to isolate human astrocytes generated from induced pluripotent stem cells. And astrocytes stand out in FTD-prone brain areas.
Induced neurons lacking the Alzheimer’s risk gene can’t properly recycle APP.
Using a form of confocal microscopy and automated software, the method allows researchers to rapidly identify functional synapses within brain structures.
The modeling approach reinforces the idea that tau pathology propagates through the brain’s physical architecture, including neuronal networks.
Built to cross the blood-brain barrier, the vehicle delivers therapeutic antibodies, enzymes, and potentially small molecules such as oligonucleotides.
Umbilical cord stem cells from presenilin 1 E280A carriers, once differentiated into cholinergic-like neurons, pumped out Aβ42 and accumulated phosphorylated tau and apoptotic markers.
In stark contrast to Aβ and tau fibrils, α-synuclein fibrils are asymmetric, comprising two different protofibrils.
Virtual Exhibit Hall
Alzforum encourages users to visit the Virtual Exhibit Hall, where companies showcase their newest initiatives, products, and services. We welcome F. Hoffmann-La Roche, joining our other exhibitors — Biogen, BioLegend, Dash Genomics, Inc., Abcam, BrainXell, and the Jackson Laboratory.
How do tangles spread through the brain? New modeling reinforces the idea that spread occurs through the axonal connections between brain regions. Researchers simulated the advance of tangles from entorhinal cortex through a virtual brain using atlases of axonal and functional connectivity. When they compared the resulting patterns to actual tau PET scans, the axonal map best predicted tangle distribution. In regions with amyloid plaques, more tangles accumulated than the model predicted, reinforcing the idea that plaques promote tau pathology.
Scientists have engineered a specialized "vehicle" capable of whisking all manner of therapeutic molecules across the blood-brain barrier. It is an antibody fragment equipped with a domain that latches onto the transferrin receptor, which normally ushers transferrin into the brain. Using the vehicle, researchers delivered BACE1 antibodies, as well as an enzyme that is lacking in a lysosomal storage disorder, into the brains of mice and monkeys.
- Debomoy Lahiri on Paper Alert: CryoEM Structures of α-Synuclein Published
- Rickie Patani on New Astrocyte Marker Allows Purification from Mixed Cultures
- M. Kerry O'Banion on New Astrocyte Marker Allows Purification from Mixed Cultures
- Olav Andersen on Without SORL1, Endosomes Swell in Neurons but not Microglia
- Lars Lannfelt and Per-Ola Freskgård on Molecular Transport Vehicle Shuttles Therapies into Brain
- Marcia Ratner on Simulating Tangle Spread Along Axons, Scientists Predict Tau PET Patterns
- David Jones on Simulating Tangle Spread Along Axons, Scientists Predict Tau PET Patterns
- Berislav Zlokovic on Molecular Transport Vehicle Shuttles Therapies into Brain
- Paul Saftig on Molecular Transport Vehicle Shuttles Therapies into Brain
- Russell Swerdlow on Umbilical Cord With Presenilin Mutation Births New Cell Model of Familial AD
- Charles Glabe on Alzheimer's Disease "Non-amyloidogenic" p3 Peptide Revisited: A Case for Amyloid-α.
- David Holtzman on In Colombian Alzheimer’s Kindred, Blood NfL Climbs 22 Years Before Symptoms
- Leslie Shaw on In Colombian Alzheimer’s Kindred, Blood NfL Climbs 22 Years Before Symptoms
- Thomas Vogels on Widely Used Tau Seeding Assay Challenged
- Jonathan Schott and Dylan Williams on Massive Proteomics Studies Peg Glial Metabolism, Myelination, to AD
- Pieter Jelle Visser and Betty Tijms on Massive Proteomics Studies Peg Glial Metabolism, Myelination, to AD
- Robert Friedland and Zimple Kurlawala on Gut Microbes: The Difference Between Life and Death in C9ORF72 Mice
- Bradley Hyman on Widely Used Tau Seeding Assay Challenged
- Lary Walker on Widely Used Tau Seeding Assay Challenged
- Benjamin Wolozin on Widely Used Tau Seeding Assay Challenged
- Bernard Hanseeuw on Could Tau PET Replace Amyloid Biomarkers as a Diagnostic for AD?