By promoting the exocytosis of cellular debris, the kinase may facilitate spread of α-synuclein aggregates.
Neuropsychological impairments are common in amyotrophic lateral sclerosis, even more so for people at late stages of disease.
A behavioral intervention slowed memory slippage and functional decline over two years.
In large cohorts, older people tested in summer and autumn scored higher on cognitive tests than people tested in winter and spring. Is a seasonal clock ticking in the background?
A new finding questions the usefulness of some mouse models.
Treatments that promote neurogenesis and elevate BDNF act as exercise does to improve memory in mouse models of Alzheimer’s disease.
Computational models predict that ALS mutations tax the flexibility of profilin-1, weaken binding with key partners including actin, and boost the protein’s propensity to aggregate.
By yanking a nuclear protein out of its pore, phosphorylated tau makes nuclei leaky, disrupting the strictly controlled passage of proteins and setting tau up for aggregation.
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New reports suggest that the PD-associated kinase steers lysosomes toward the cell membrane, where they promptly disgorge their contents into the extracellular space. The jetsam causes inflammation and helps spread toxic synuclein and perhaps even other proteins, the authors contend. The findings bolster the rationale for developing LRRK2 inhibitors.
A handful of labs have used CRISPR gene editing to introduce the infamous AD risk mutation—TREM2 R47H—into mice. The mutation dampened expression of the microglial receptor. A new study reports that splicing defects are to blame. However, splicing shenanigans only affect the mouse, not human, gene, calling into question the usefulness of four R47H TREM2 mouse models.
Evidence suggests that daily exercise can delay or prevent the onset of Alzheimer’s disease symptoms. Scientists now claim to have figured out how to mimic that pharmacologically. Using a combination of drugs and gene therapy, they improved spatial navigation in mouse models of AD. The secret? Promoting the birth of new neurons while also inducing neurotrophins to keep them viable. With this combo, sedentary mice had smarts like those that ran on a treadmill for hours, the researchers report.
- Hugh Hendrie on Lifestyle Coaching Slows Cognitive Decline in African-Americans with MCI
- Walter Kukull on Lifestyle Coaching Slows Cognitive Decline in African-Americans with MCI
- Quyen Hoang on Does LRRK2 Sweep α-Synuclein from the Cell?
- Sabine Hilfiker on Does LRRK2 Sweep α-Synuclein from the Cell?
- Erik Musiek on Does Cognition Change With the Seasons?
- Matthew Pase on Does Cognition Change With the Seasons?
- Gernot Kleinberger and Christian Haass on Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
- Bruce Lamb on Model Morass? R47H Mutation Scuttles TREM2 Expression in Mice, Not People
- Jack Rogers on Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease.
- Jürgen Götz on Tau Stymies Transport Through Neuron’s Nucleus
- P. Hande Ozdinler on ALS Mutations Stiffen Profilin, Steer Protein Toward Aggregation
- Serge Rivest on TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.
- Volkmar Lessmann on Exercise Pill? Pharmacological Mimics Boost Cognition in Lazy Mice
- Michael Lardelli on Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin.
- Keith Johnson on Flortaucipir Meets Primary Endpoints in Phase 3 Autopsy Trial
- Yoshinori Tanaka on ALS Mutations Stiffen Profilin, Steer Protein Toward Aggregation
- Tsuneya Ikezu on Exercise Pill? Pharmacological Mimics Boost Cognition in Lazy Mice
- Gerd Kempermann on Exercise Pill? Pharmacological Mimics Boost Cognition in Lazy Mice
- Diego Mastroeni on Tau Stymies Transport Through Neuron’s Nucleus
- Richard Ransohoff on Tiny Passageways Connect Skull Bone Marrow to the Brain
- James Vickers, Matthew Kirkcaldie and Anna King on Blood Test for Neurofilament Light Chain Kicks Up Biomarker Research