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Alzheimer Disease—The Fragile X Syndrome Connection

At first blush, Alzheimer disease and fragile X syndrome may appear as chalk and cheese, since the former is a neurodegenerative disease and the latter a developmental disorder. However, both are characterized by synaptic pathology and as exemplified by a ...

Stress Granules and Neurodegenerative Disease—What’s the Scoop?

The formation of cytoplasmic inclusions called stress granules is one of nature’s many ways of coping with adverse situations. It appears that these inclusions sequester non-essential messenger RNAs, allowing cells to focus on making proteins, such as ...

Evolution of AD Trials

In a sign that researchers are grappling with therapy development, the 4th International Conference on Clinical Trials on Alzheimer's Disease was filled beyond the capacity of its venue, drawing 522 researchers from around the globe. Held 3-5 ...

Volunteers Help Scientists Explore Down’s, Alzheimer’s Nexus

Children born with Down’s syndrome can receive excellent healthcare at specialized clinics, but once they become adults, their care often falls to doctors who may be less qualified to deal with their specific needs. The new Down Syndrome Center for ...

Adding Dynamics and Nuance to Alzheimer’s Staging

Being able to image amyloid, glucose metabolism, atrophy, even network connectivity in living patients has been a boon for those trying to stage the progression of Alzheimer’s disease. Using magnetic resonance imaging (MRI) and positron emission ...

How Cognitive Stimulation Might Protect Against Aβ Oligomers

Cognitive stimulation has been shown to lower the risk of Alzheimer’s disease, but what actually happens in the brain to confer protection? In the March 6 Neuron, researchers led by Dennis Selkoe report that β2-adrenergic signaling plays a key role. Wild ...

Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?

Could the protein aggregates that cause neurodegeneration turn out to be the cellular equivalent of ice cubes? Scientists investigating how proteins naturally transition between gas-like solutions, condensed liquids, solidified gels, and insoluble fibrils ...

The Alzheimer Biomarker Knowledge Base

Debra Revere discussed how the tools developed by the Telemakus Research Group have been used to extract research methods, animal models, data from tables and figures, and research results from published literature.   View Presentation You will need ...

Intraneuronal Aβ: Was It APP All Along?

On 16 June 2011, ARF held a Webinar with Eddie Lee, Todd Golde, Gunnar Gouras, Frank LaFerla, Virginia Lee, Lars Nilsson, and Robert Vassar to discuss this study’s implications for intraneuronal Aβ and its role in AD pathogenesis. The Guest Moderator was ...

Learn About AD Biomarker Meta-Analysis on AlzBiomarker Database

In the April 8 Lancet Neurology, researchers led by Bob Olsson at the University of Gothenburg, Sweden, reported the most comprehensive meta-analysis of published Alzheimer’s disease fluid biomarker data to date. The researchers scoured literature going ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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