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Intraneuronal Aβ: Was It APP All Along?

On 16 June 2011, ARF held a Webinar with Eddie Lee, Todd Golde, Gunnar Gouras, Frank LaFerla, Virginia Lee, Lars Nilsson, and Robert Vassar to discuss this study’s implications for intraneuronal Aβ and its role in AD pathogenesis. The Guest Moderator was ...

Weeding Mendel’s Garden: Can We Hoe Dubious Genetic Associations?

Scientists have uncovered hundreds of genetic variants that purportedly cause familial forms of various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementias, and amyotrophic lateral sclerosis. But are all of these ...

Volunteers Help Scientists Explore Down’s, Alzheimer’s Nexus

Children born with Down’s syndrome can receive excellent healthcare at specialized clinics, but once they become adults, their care often falls to doctors who may be less qualified to deal with their specific needs. The new Down Syndrome Center for ...

Are Neurons Just Too Laissez-Faire about Repair?

Thierry Nouspikel led this live discussion on 14 July 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Dr. Thierry Nouspikel led this live discussion on 14 July 2003. Moderated by Dr ...

The Pathogen Hypothesis

June Kinoshita, with Brian Balin, Denah Appelt, Joseph Lyons, Ruth Itzhaki, and Curtis Dobson, led this live discussion on 1 July 2004. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.    Itzhaki RF, ...

Calcium in AD Pathogenesis

A Live Webinar Discussion was held on 29 October 2008, with presentations from Ilya Bezprozvanny, Beth Stutzmann, Kevin Foskett, Kim Green, and Brian Bacskai and Kishore Kuchibhotla. This live discussion began with a Webinar featuring a slide talk with ...

Alzheimer Disease—The Fragile X Syndrome Connection

At first blush, Alzheimer disease and fragile X syndrome may appear as chalk and cheese, since the former is a neurodegenerative disease and the latter a developmental disorder. However, both are characterized by synaptic pathology and as exemplified by a ...

Slow Aβ Clearance Is ApoE4’s Modus Operandi in Late-Onset AD

Alzforum has been pleased to partner with the journal Science Translational Medicine in hosting a Webinar discussion of a new Alzheimer’s disease research study published 29 June 2011. The journal generously granted free access to Castellano et al. for ...

ADCS Prevention Instrument Project

There is now a concerted push in the research community to find pharmacological and/or non-pharmacological interventions that can prevent or slow the progression of Alzheimer disease. But prevention trials promise to be long and potentially costly affairs ...

Evolution of AD Trials

In a sign that researchers are grappling with therapy development, the 4th International Conference on Clinical Trials on Alzheimer's Disease was filled beyond the capacity of its venue, drawing 522 researchers from around the globe. Held 3-5 ...

Stress Granules and Neurodegenerative Disease—What’s the Scoop?

The formation of cytoplasmic inclusions called stress granules is one of nature’s many ways of coping with adverse situations. It appears that these inclusions sequester non-essential messenger RNAs, allowing cells to focus on making proteins, such as ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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