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Mice on Trial? Issues in the Design of Drug Studies

Tiny and timid though it may be, the humble house mouse is not only one of the most successful mammalian species on Earth, but is also the dominant model organism for medical research, especially because of the ease with which it can be genetically ...

Non-coding RNAs in Neurodegeneration

Peter T. Nelson led this Webinar from 12:00-1:30 p.m. (U.S. Eastern Time) on Friday, 26 October 2007. Transcript: Participants: Peter Nelson (University of Kentucky), Ben Albensi (St. Boniface Res Ctr/Univ of Manitoba), Laura Turner (Eisai London Research ...

APP Family: Clues to Function in Health and AD

The amyloid precursor protein was first cloned in 1987. Twenty years and 4,000+ papers later, the function of APP is still shrouded in mystery, despite the overwhelming weight of evidence linking the precursor protein to Alzheimer disease. Is the field ...

The AD8: A Brief Screening Tool for Very Mild Dementia

Jim Galvin and colleagues at Washington University, St. Louis, Missouri, have developed a simple tool to discern very early dementia in routine clinical settings. The field overwhelmingly agrees that dementia should be detected as early as possible, yet ...

Susceptibility Testing and Risk Assessment in Alzheimer Disease

News about a not-too-distant future of personal genomics is coming at us hard and fast. For example, the New York Times reported on June 1 that the complete DNA sequence of Nobel laureate James C. Watson, of DNA double-helix fame, has been sequenced and ...

Presenilin Loss of Function—Plan B for AD?

These are comfortable times for the amyloid hypothesis, it would seem. Every week brings more good news about some anti-amyloid intervention having “cured” mice from their “Alzheimer’s.” On the human front, we are eagerly awaiting such therapeutics to ...

ADCS Prevention Instrument Project

There is now a concerted push in the research community to find pharmacological and/or non-pharmacological interventions that can prevent or slow the progression of Alzheimer disease. But prevention trials promise to be long and potentially costly affairs ...

Alzheimer Disease—The Fragile X Syndrome Connection

At first blush, Alzheimer disease and fragile X syndrome may appear as chalk and cheese, since the former is a neurodegenerative disease and the latter a developmental disorder. However, both are characterized by synaptic pathology and as exemplified by a ...

The Alzheimer Biomarker Knowledge Base

Debra Revere discussed how the tools developed by the Telemakus Research Group have been used to extract research methods, animal models, data from tables and figures, and research results from published literature.    View Presentation You will need ...

Whole Genome Study for Parkinson Disease

Katrina Gwinn-Hardy led this Web seminar and discussion on the whole genome study of Parkinson disease which was published recently in Lancet Neurology. Co-author Gwinn-Hardy presented the findings and introduced some discussion topics around data sharing ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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