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Is Alzheimer’s Disease a Uniquely Human Disorder?

Add Private note Add An editorial note Humans are not alone in accumulating Aβ in their brain. Squirrel monkeys, vervets, lemurs, apes, other nonhuman primates, and even dogs develop copious amyloid plaques and cerebral amyloid angiopathy as they age. ...

Learn About AD Biomarker Meta-Analysis on AlzBiomarker Database

In the April 8 Lancet Neurology, researchers led by Bob Olsson at the University of Gothenburg, Sweden, reported the most comprehensive meta-analysis of published Alzheimer’s disease fluid biomarker data to date. The researchers scoured literature going ...

Webinar: Pathogenic Protein Spread? Let’s Think Again

Multiple lines of evidence have converged on the idea that toxic variants of Aβ, α-synuclein, and tau worm their way from one cell to the next, seeding the misfolding and aggregation of normal proteins as they go. In this manner, a growing number of ...

Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?

Could the protein aggregates that cause neurodegeneration turn out to be the cellular equivalent of ice cubes? Scientists investigating how proteins naturally transition between gas-like solutions, condensed liquids, solidified gels, and insoluble fibrils ...

Leaky Blood-Brain Barrier a Harbinger of Alzheimer's?

To sate the brain’s voracious hunger for energy, thousands of capillaries deliver blood and oxygen to every sulcus and gyrus, and the white and gray matter in between. Herein lies a problem. The delicate cells of the brain must be protected from the ...

Good-Bye Overexpression, Hello APP Knock-in. A Better Model?

Researchers rely on transgenic mice to model Alzheimer's disease, but these models are far from perfect. Some can only be maintained on specific genetic backgrounds, some die young or have surprising phenotypes when crossed with other mouse lines, ...

Neurovascular Underpinnings of Alzheimer's Dementia

Whether it’s a Bach concerto, Fermat's last theorem, or simply remembering the way home from the grocery store, cognition comes at a price. The brain depends on an elaborate network of blood vessels to feed its voracious appetite for oxygen and ...

Webinar: O Blood-Based Biomarker, Where Art Thou?

Our Webinar on 17 June 2013 covered the latest research and future directions on blood-based biomarkers discussed at a recent Alzheimer’s Drug Discovery Foundation/Alzheimer’s Association conference. Sid O’Bryant, Texas Tech University, Lubbock; Samantha ...

Using ADNI Data—Online Training, Part 1

On 4 April 2013, the Alzheimer's Disease Neuroimaging Initiative biostatistics core held the first session of its two-part online training course on using ADNI data. Led by Danielle Harvey of the University of California, Davis, the session gave a ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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