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Good-Bye Overexpression, Hello APP Knock-in. A Better Model?

Researchers rely on transgenic mice to model Alzheimer's disease, but these models are far from perfect. Some can only be maintained on specific genetic backgrounds, some die young or have surprising phenotypes when crossed with other mouse lines, ...

Neurovascular Underpinnings of Alzheimer's Dementia

Whether it’s a Bach concerto, Fermat's last theorem, or simply remembering the way home from the grocery store, cognition comes at a price. The brain depends on an elaborate network of blood vessels to feed its voracious appetite for oxygen and ...

Webinar: O Blood-Based Biomarker, Where Art Thou?

Our Webinar on 17 June 2013 covered the latest research and future directions on blood-based biomarkers discussed at a recent Alzheimer’s Drug Discovery Foundation/Alzheimer’s Association conference. Sid O’Bryant, Texas Tech University, Lubbock; Samantha ...

Using ADNI Data—Online Training, Part 1

On 4 April 2013, the Alzheimer's Disease Neuroimaging Initiative biostatistics core held the first session of its two-part online training course on using ADNI data. Led by Danielle Harvey of the University of California, Davis, the session gave a ...

How Cognitive Stimulation Might Protect Against Aβ Oligomers

Cognitive stimulation has been shown to lower the risk of Alzheimer’s disease, but what actually happens in the brain to confer protection? In the March 6 Neuron, researchers led by Dennis Selkoe report that β2-adrenergic signaling plays a key role. Wild ...

Neuroinflammation—A Prelude to Alzheimer's?

Neuroinflammation plays a major role in Alzheimer's disease, but whether it represents a cause or a response to pathology is unclear. In the November 27 Nature Reviews Neurology, Dimitrije Krstic and Irene Knuesel argue that age-related chronic ...

International Student Workshop on AD

What makes a good grant proposal in Alzheimer’s research? How to develop and present it? What are funders looking for? Students from all over the world learned the answers by working hands-on with established Alzheimer’s disease researchers at a workshop ...

Latest γ-Secretase Substrate Involved in Synaptic Stability, Autism?

Over the years, γ-secretase has garnered intense interest from scientists and drug developers who have targeted the multimeric complex in an attempt to curb production of amyloid-β (Aβ), the peptide believed to underlie Alzheimer’s disease. Meanwhile, the ...

Weeding Mendel’s Garden: Can We Hoe Dubious Genetic Associations?

Scientists have uncovered hundreds of genetic variants that purportedly cause familial forms of various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementias, and amyotrophic lateral sclerosis. But are all of these ...

AD in the Oldest Old—What Does Aβ Have to Do With It?

In a keynote lecture at the Human Amyloid Imaging conference, held 12-13 January 2012 in Miami, Florida, Claudia Kawas argued that the oldest old should receive more attention. Kawas leads the world’s largest study of people 90 and older. Listen to the ...

Who Should Use the New Diagnostic Guidelines? The Debate Continues

Download a PDF of this Forum Discussion Ever since new criteria came out for a research diagnosis of prodromal/preclinical Alzheimer’s disease, plus criteria for a research and clinical diagnosis of the MCI and dementia stages of the disease, they have ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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