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Role and Control of Metal-Mediated Fibril Toxicity

David Allsop and Ashley Bush led this live discussion on 20 December 2004. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live Discussion led by David Allsop, Ashley Bush, and co ...

Clearing the Fog Around Aβ Oligomers

Like calling a spade a spade? What about an Aβ oligomer? The study of this peptide’s oligomers has taken off in the last decade. Many labs have developed their own favorite means of making, purifying, and studying them. Researchers have isolated dimers, ...

AD in the Oldest Old—What Does Aβ Have to Do With It?

In a keynote lecture at the Human Amyloid Imaging conference, held 12-13 January 2012 in Miami, Florida, Claudia Kawas argued that the oldest old should receive more attention. Kawas leads the world’s largest study of people 90 and older. Listen to the ...

Neuroinflammation—A Prelude to Alzheimer's?

Neuroinflammation plays a major role in Alzheimer's disease, but whether it represents a cause or a response to pathology is unclear. In the November 27 Nature Reviews Neurology, Dimitrije Krstic and Irene Knuesel argue that age-related chronic ...

Betwixt and Intermixed—Dementia With Lewy Bodies

On 15 June 2009, we hosted a Webinar discussion with slide presentations by Ian McKeith at Newcastle University, UK, James Leverenz at University of Washington, Seattle, James Galvin, Washington University, St. Louis, Brit Mollenhauer of Paracelsus-Elena ...

Together at Last, Top Five Biomarkers Model Stages of AD

In this Webinar, Clifford Jack gave a slide talk summarizing a staged biomarker model of the Alzheimer’s cascade, followed by a panel discussion with Chet Mathis, David Holtzman, Henrik Zetterberg, Paul Aisen, Keith Johnson, Giovanni Frisoni, Douglas ...

Presenilin Loss of Function—Plan B for AD?

These are comfortable times for the amyloid hypothesis, it would seem. Every week brings more good news about some anti-amyloid intervention having “cured” mice from their “Alzheimer’s.” On the human front, we are eagerly awaiting such therapeutics to ...

The Neuroplasticity Theory of Alzheimer's Disease

J. Wesson Ashford led this live discussion on 8 April 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held Tuesday, 8 April 2002 Participants: John Wesson Ashford ...

Good-Bye Overexpression, Hello APP Knock-in. A Better Model?

Researchers rely on transgenic mice to model Alzheimer's disease, but these models are far from perfect. Some can only be maintained on specific genetic backgrounds, some die young or have surprising phenotypes when crossed with other mouse lines, ...

In Search of γ-Secretase

Peter Nelson, with Dennis Selkoe, John Hardy, and Alain Israel, led this live discussion on 5 May 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion with Dennis Selkoe, ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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