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How Cognitive Stimulation Might Protect Against Aβ Oligomers

Cognitive stimulation has been shown to lower the risk of Alzheimer’s disease, but what actually happens in the brain to confer protection? In the March 6 Neuron, researchers led by Dennis Selkoe report that β2-adrenergic signaling plays a key role. Wild ...

The AD8—Dementia Screen Ready for Prime Time?

Have you been waiting for a quick yet reliable test for early dementia? The AD8 might be your answer. The interview-based screening tool detects early cognitive impairment, has been validated against the clinical dementia rating scale and against ...

Leaky Blood-Brain Barrier a Harbinger of Alzheimer's?

To sate the brain’s voracious hunger for energy, thousands of capillaries deliver blood and oxygen to every sulcus and gyrus, and the white and gray matter in between. Herein lies a problem. The delicate cells of the brain must be protected from the ...

Neuroinflammation—A Prelude to Alzheimer's?

Neuroinflammation plays a major role in Alzheimer's disease, but whether it represents a cause or a response to pathology is unclear. In the November 27 Nature Reviews Neurology, Dimitrije Krstic and Irene Knuesel argue that age-related chronic ...

Clearing the Fog Around Aβ Oligomers

Like calling a spade a spade? What about an Aβ oligomer? The study of this peptide’s oligomers has taken off in the last decade. Many labs have developed their own favorite means of making, purifying, and studying them. Researchers have isolated dimers, ...

Grasping the Shadow Force: Immune Cells in ALS

When two biological networks as complex as the nervous and immune systems cross paths, you know the interaction is not going to be simple. Add in neurodegeneration—such as amyotrophic lateral sclerosis—and it creates a web that will take many scientists ...

Calcium in AD Pathogenesis

A Live Webinar Discussion was held on 29 October 2008, with presentations from Ilya Bezprozvanny, Beth Stutzmann, Kevin Foskett, Kim Green, and Brian Bacskai and Kishore Kuchibhotla. This live discussion began with a Webinar featuring a slide talk with ...

Mice on Trial? Issues in the Design of Drug Studies

Tiny and timid though it may be, the humble house mouse is not only one of the most successful mammalian species on Earth, but is also the dominant model organism for medical research, especially because of the ease with which it can be genetically ...

Herpes Simplex and Alzheimer’s—Time to Think Again?

On Thursday, 24 February 2011, Ruth Itzhaki, University of Manchester, U.K.; Elisa Porcellini, University of Bologna, Italy; Luc Letenneur, INSERM, Bordeaux, France, and Richard Smeyne, St. Jude Children’s Research Hospital, Memphis, Tennessee, shared ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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