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Susceptibility Testing and Risk Assessment in Alzheimer Disease

News about a not-too-distant future of personal genomics is coming at us hard and fast. For example, the New York Times reported on June 1 that the complete DNA sequence of Nobel laureate James C. Watson, of DNA double-helix fame, has been sequenced and ...

Presenilin Loss of Function—Plan B for AD?

These are comfortable times for the amyloid hypothesis, it would seem. Every week brings more good news about some anti-amyloid intervention having “cured” mice from their “Alzheimer’s.” On the human front, we are eagerly awaiting such therapeutics to ...

ADCS Prevention Instrument Project

There is now a concerted push in the research community to find pharmacological and/or non-pharmacological interventions that can prevent or slow the progression of Alzheimer disease. But prevention trials promise to be long and potentially costly affairs ...

Alzheimer Disease—The Fragile X Syndrome Connection

At first blush, Alzheimer disease and fragile X syndrome may appear as chalk and cheese, since the former is a neurodegenerative disease and the latter a developmental disorder. However, both are characterized by synaptic pathology and as exemplified by a ...

The Alzheimer Biomarker Knowledge Base

Debra Revere discussed how the tools developed by the Telemakus Research Group have been used to extract research methods, animal models, data from tables and figures, and research results from published literature.   View Presentation You will need ...

Whole Genome Study for Parkinson Disease

Katrina Gwinn-Hardy led this Web seminar and discussion on the whole genome study of Parkinson disease which was published recently in Lancet Neurology. Co-author Gwinn-Hardy presented the findings and introduced some discussion topics around data sharing ...

Webinar: Axonopathy in Mouse Models of AD

Despite the availability of a wide range of animal models of Alzheimer disease, none of them are able to fully recapitulate all the facets of the disease. Axonopathy is a case in point. Although there has been renewed interest in the link between axonal ...

Webinar: The NeuronDB Knowledge Base

Gordon Shepherd and Kei Cheung from Yale University led this Web seminar. Our featured presenters provided an introduction to SenseLab, which is a long-standing database project to build integrated multidisciplinary models of neurons and neural systems. ...

Data-mining for Medications That Affect the Incidence of Dementia

Ben Wolozin of the Boston University School of Medicine presented some results from analyzing a 4.5 million-subject database of medical records to identify medications that are associated with reduction or increase in the incidence of dementia. His team& ...

M1 Receptors Play a Central Role in AD Pathology and Cognition

Our thanks to Neuron for providing free access to this paper for the purposes of this live discussion. Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, LaFerla FM. M1 receptors play a central role in modulating AD-like pathology in ...

An Idiosyncratic View of AD Biomarkers

Dr. Coleman led this live discussion on how biomarker information and basic science of AD can inform each other. He reviewed how the more common biomarkers of tau and Aß peptides relate to the major neurobiological deficits in AD—synaptic loss and ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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