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AD in the Oldest Old—What Does Aβ Have to Do With It?

In a keynote lecture at the Human Amyloid Imaging conference, held 12-13 January 2012 in Miami, Florida, Claudia Kawas argued that the oldest old should receive more attention. Kawas leads the world’s largest study of people 90 and older. Listen to the ...

The Neuroplasticity Theory of Alzheimer's Disease

J. Wesson Ashford led this live discussion on 8 April 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held Tuesday, 8 April 2002 Participants: John Wesson Ashford ...

Androgens, ApoE, and Alzheimer's Disease

This discussion was produced in collaboration with SAGE KE. Jacob Raber led this live discussion on 7 May 2004. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript unavailable. Background Text ...

Not Dead Yet: Estrogen Deserves Another Chance

You may think the Women’s Health Study has sounded the death knell for estrogen replacement therapy, but actually, the idea is showing new signs of life. A second-generation approach with better compounds may warrant continued investment, and yet, how ...

New Models for Integrative Care of Alzheimer Disease

On 25 June 2010, Ken Kosik, M.D., a neuroscientist at the University of California, Santa Barbara (UCSB), and the executive director of Cognitive Fitness and Innovative Therapies (CFIT), led a Webinar about CFIT, which he describes as "the first full ...

Clearing the Fog Around Aβ Oligomers

Like calling a spade a spade? What about an Aβ oligomer? The study of this peptide’s oligomers has taken off in the last decade. Many labs have developed their own favorite means of making, purifying, and studying them. Researchers have isolated dimers, ...

Grasping the Shadow Force: Immune Cells in ALS

When two biological networks as complex as the nervous and immune systems cross paths, you know the interaction is not going to be simple. Add in neurodegeneration—such as amyotrophic lateral sclerosis—and it creates a web that will take many scientists ...

Leaky Blood-Brain Barrier a Harbinger of Alzheimer's?

To sate the brain’s voracious hunger for energy, thousands of capillaries deliver blood and oxygen to every sulcus and gyrus, and the white and gray matter in between. Herein lies a problem. The delicate cells of the brain must be protected from the ...

Weeding Mendel’s Garden: Can We Hoe Dubious Genetic Associations?

Scientists have uncovered hundreds of genetic variants that purportedly cause familial forms of various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementias, and amyotrophic lateral sclerosis. But are all of these ...

Slow Aβ Clearance Is ApoE4’s Modus Operandi in Late-Onset AD

Alzforum has been pleased to partner with the journal Science Translational Medicine in hosting a Webinar discussion of a new Alzheimer’s disease research study published 29 June 2011. The journal generously granted free access to Castellano et al. for ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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