Is Alzheimer’s Disease a Uniquely Human Disorder?

• 1 Comment

07 Dec 2016

is not certain. A question raised by another participant is whether there are protective sites

Webinar: Pathogenic Protein Spread? Let’s Think Again

• 3 Comments

28 Mar 2016

rigorous methods to reconcile aggregation of α-synuclein in enteric or other peripheral sites before

Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?

08 Oct 2015

or hydrogels. Since FUS localizes to sites of transcription in cells, they hypothesized it might interact

Computational Modeling—Will it Rescue AD Clinical Trials?

• 1 Comment

01 May 2015

The Alzheimer's field has had its share of clinical trial flops. Now there's a push to learn from past failures. Computational scientists in pharmaceutical companies are guiding clinical trial design by first putting drug candidates through thei

Leaky Blood-Brain Barrier a Harbinger of Alzheimer's?

• 1 Comment

30 Jan 2015

To sate the brain’s voracious hunger for energy, thousands of capillaries deliver blood and oxygen to every sulcus and gyrus, and the white and gray matter in between. Herein lies a problem. The delicate cells of the brain must be protected from the flots

New Frontier: Developing Outcome Measures for Pre-dementia Trials

• 3 Comments

09 Apr 2013

from each other (due to entry criteria, patient population differences, and study site differences)

Using ADNI Data—Online Training, Part 1

08 Apr 2013

the visualization tools available on the ADNI data site. A second training session to be scheduled at a later date

Neuroinflammation—A Prelude to Alzheimer's?

• 3 Comments

20 Dec 2012

injury (TBI) models, there is a substantial increase in APP expression and accumulation at the sites

Who Should Use the New Diagnostic Guidelines? The Debate Continues

13 Jan 2012

into secondary and primary care sites throughout the community? Has the time come to apply the new guidelines

Resolving Controversies on the Path to AD Therapeutics

• 3 Comments

06 Oct 2011

for Bright New Ideas?, Dr. Herrup at Rutgers on Slide 8 stated that “Site of plaques ≠ site

Intraneuronal Aβ: Was It APP All Along?

20 Jun 2011

On 16 June 2011, ARF held a Webinar with Eddie Lee, Todd Golde, Gunnar Gouras, Frank LaFerla, Virginia Lee, Lars Nilsson, and Robert Vassar to discuss this study’s implications for intraneuronal Aβ and its role in AD pathogenesis. The Guest Moderator was

Grasping the Shadow Force: Immune Cells in ALS

• 1 Comment

12 May 2011

with microglia—the nervous system’s resident immune cells—around sites of damage. Human studies suggest that immune

Reimagining Alzheimer's Disease—Time for Bright New Ideas?

• 9 Comments

03 May 2011

Alois Alzheimer made a major breakthrough when he discovered senile plaques in the brains of dementia patients, and his work ultimately led to the discovery of amyloid-β and to the amyloid cascade hypothesis. But that cascade is only part of a much bigger

Herpes Simplex and Alzheimer’s—Time to Think Again?

• 14 Comments

15 Apr 2011

antibody in peripheral blood could indicate reactivation at any peripheral site. As Letteneur explained,

Microdissection and Microarrays: Analyzing Selective Cell Vulnerability

• 2 Comments

16 Sep 2010

As Tolstoy wrote in Anna Karenina, “Happy families are all alike; every unhappy family is unhappy in its own way.” The same might be said of the brain. Normal brains look and behave similarly, but those affected by different neurodegenerative diseases are