Breaking News

30 Sep 2016. Topline results from Lundbeck's frist Phase 3 trial for idalopirdine indicate the compound failed to slow cognitive decline over the six-month trial period when paired with donepezil.  Three more Phase 3 trials for the compound are onging (see Sep 2016 news).

This database provides a catalog of the therapeutics currently or previously tested as treatment for Alzheimer's disease and related disorders, focusing on those that have progressed to Phase 2 or beyond in U.S. clinical trials. We strive to keep this database up-to-date and welcome you to contact us at


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AD Target / Therapy Types

The two tables below organize the therapeutics within this database by therapy type and proposed target type. The number of therapeutics within each category is indicated according to the highest phase each therapeutic has achieved in U.S. clinical trials. For example, if a given therapeutic is in both Phase 2 and Phase 3 trials, it is included in the Phase 3 total.


Recent Comments

  1. Kristina Capiak on Anavex 2-73

Further Reading


  1. A Levodopa Inhaler for Parkinson’s?
  2. Could a Failed Heart Drug Treat Tauopathies?
  3. STARSHINE Trial Loses its Luster
  4. First Round of FTD Therapeutics Fell Short, But Many More Are Up and Running


  1. Suzanne Hendrix on Constructing Composites for Trials in Early Alzheimer’s
  2. Computational Modeling—Will it Rescue AD Clinical Trials?
  3. Resolving Controversies on the Path to AD Therapeutics
  4. Treating Before Symptoms—ADCS Invites Ideas for Clinical Trials in Very Early AD

Other Resources

ADDF ACCESS is a program to provide scientists in academia and small biotechnology companies with access to a virtual network of drug discovery experts and contract research organizations (CROs) that have experience developing therapies for neurodegenerative diseases.

Patient Resources