Therapeutics

Suritozole

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Overview

Name: Suritozole
Synonyms: MD 26479
Therapy Type: Small Molecule
Target Type: Other Neurotransmitters
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)
Company: Aventis Pharmaceuticals, Inc. (was Hoechst)

Background

Suritozole is an inverse agonist at the GABA(A) receptor (Miller et al., 1992). GABA(A) receptor activity affects cholinergic function in the hippocampus and cerebral cortex (Richter et al., 1982; Wenk, 1984). This drug was found to improve memory performance in rats with scopolamine-induced memory acquisition deficits (Moran et al., 1992). 

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References

Paper Citations

  1. . MDL 26,479: a potential cognition enhancer with benzodiazepine inverse agonist-like properties. Br J Pharmacol. 1992 Sep;107(1):78-86. PubMed.
  2. . Inhibition of high affinity choline uptake in the hippocampus: studies on the site of pentobarbital action. J Pharmacol Exp Ther. 1982 Sep;222(3):778-85. PubMed.
  3. . Pharmacological manipulations of the substantia innominata-cortical cholinergic pathway. Neurosci Lett. 1984 Sep 28;51(1) PubMed.
  4. . Enhancement of working memory performance in the rat by MDL 26,479, a novel compound with activity at the GABAA receptor complex. Brain Res. 1992 Jan 8;569(1) PubMed.

Further Reading

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