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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
ABT 418 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
ABT-089 Discontinued Abbott Laboratories Cholinergic System Small Molecule Alzheimer's Disease
ABT-126 2 AbbVie Cholinergic System Small Molecule Alzheimer's Disease
ABT-288 Discontinued AbbVie Other Neurotransmitters Small Molecule Alzheimer's Disease
ABT-384 Discontinued AbbVie Other Small Molecule Alzheimer's Disease
ABT-957 1 AbbVie Other Small Molecule Alzheimer's Disease
Acitretin Soriatane ,
Neotigason,
RO 101670
2 Stiefel Laboratories, Inc. Amyloid-Related Small Molecule Alzheimer's Disease Psoriasis in US
AF 102B cevimeline HCL,
Evoxac™
Discontinued SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Alzheimer's Disease Treatment of dry mouth in Sjogren's syndrome.
Anavex 2-73 1 Anavex Life Science Corp. Other Small Molecule Alzheimer's Disease
Atomoxetine ATX,
Strattera
Discontinued Eli Lilly & Co. Other Neurotransmitters Small Molecule Alzheimer's Disease ADHD in US
Atorvastatin Lipitor™ ,
Zarator®,
Sortis®,
Tahor®
Inactive Pfizer Cholesterol Small Molecule Alzheimer's Disease Hypercholesterolaemia
Avagacestat BMS-708163 Discontinued Bristol-Myers Squibb Amyloid-Related Small Molecule Alzheimer's Disease
AZD1446 TC-6683 Discontinued AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease None
AZD3293 BACE1 inhibitor 2/3 AstraZeneca Amyloid-Related Small Molecule Alzheimer's Disease
AZD3480 ispronicline,
TC-1734
Inactive AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease
Besipirdine HCl HP 749 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
Bexarotene Targretin® 2 Unknown Small Molecule Mild Cognitive Impairment Cutaneous T-cell Lymphoma in US
Brexpiprazole OPC 34712 3 H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease
Carvedilol Coreg,
Artist ,
Aucardic,
Dilatrend,
Kredex
4 Procter & Gamble Unknown Small Molecule Alzheimer's Disease Hypertension, heart failure, angina pectoris
CHF 5074 2, Inactive CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule Mild Cognitive Impairment, Alzheimer's Disease
Circadin 2 Neurim Pharmaceuticals Ltd. Other Small Molecule Alzheimer's Disease Insomnia in US
Clioquinol iodochlorhydroxyquin,
PBT-1
Discontinued Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule Alzheimer's Disease
CX516 Ampalex Discontinued Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease None
Dapsone Avlosulfon,
Diaminodiphenylsulfone,
DDS
Inactive Immune Network Ltd. Other Small Molecule Alzheimer's Disease Leprosy, malaria, some bacterial skin infections
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Discontinued, Discontinued Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Alzheimer's Disease, Huntington's Disease Anti-histamine use in Russia
Donepezil Aricept™,
Donepezil hydrochloride,
Eranz®,
E 2020
Approved, 3, 2, 3 Eisai Co., Ltd., Pfizer Cholinergic System Small Molecule Alzheimer's Disease, Dementia with Lewy Bodies, Down's Syndrome, Parkinson's Disease Dementia Alzheimer's Disease
E2609 BACE1 inhibitor 1 Biogen Idec, Eisai Co., Ltd. Amyloid-Related Small Molecule Alzheimer's Disease
EHT 0202 Etazolate 2 ExonHit Therapeutics Other Small Molecule Alzheimer's Disease None
ELND005 AZD-103,
Scyllo-inositol,
cyclohexane-1,2,3,4,5,6-hexol
2 Elan Corporation, Speranza Therapeutics Amyloid-Related Small Molecule Alzheimer's Disease None
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
3, 3 FORUM Pharmaceuticals Inc. (was EnVivo Pharmaceuticals), Mitsubishi Tanabe Pharma Cholinergic System Small Molecule Alzheimer's Disease, Schizophrenia None
Epothilone D BMS-241027 Discontinued Bristol-Myers Squibb Tau Small Molecule Alzheimer's Disease
Eptastigmine MF 201 Discontinued Mediolanum Cholinergic System Small Molecule Alzheimer's Disease None
EVP-0962 EVP 0015962 2, 2 FORUM Pharmaceuticals Inc. (was EnVivo Pharmaceuticals) Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
Exendin-4 Exenatide,
Byetta,
Bydureon
2 Other Small Molecule Alzheimer's Disease Diabetes mellitus in US
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Discontinued Myriad Genetics & Laboratories Amyloid-Related Small Molecule Alzheimer's Disease None
FRM-0334 EVP-0334 2 FORUM Pharmaceuticals Inc. (was EnVivo Pharmaceuticals) Other Small Molecule Frontotemporal Dementia
G-CSF Filgrastim 2 Other Small Molecule Alzheimer's Disease Neutropenia in US
Galantamine Razadyne™,
Reminyl™,
Nivalin®
Approved Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company Cholinergic System Small Molecule Alzheimer's Disease Mild to Moderate Alzheimer's disease
GC 021109 1 GliaCure Inflammation Small Molecule Alzheimer's Disease
GLN-1062 Memogain 1 Galantos Pharma, Neurodyn Cholinergic System Small Molecule Alzheimer's Disease
GSK239512 Discontinued GlaxoSmithKline (GSK) Other Neurotransmitters Small Molecule Alzheimer's Disease
GSK2647544 GSK-2647544 1 GlaxoSmithKline (GSK) Cholesterol Small Molecule Alzheimer's Disease
HF0220 Discontinued Hunter-Fleming Ltd (now Newron) Inflammation Small Molecule Alzheimer's Disease
Huperzine A ZT-1,
DEBIO 9902 ,
Qian ceng ta,
Cerebra capsule,
Pharmassure Memorall capsule
Inactive Debiopharm Group™, Neuro-Hitech, Inc. Cholinergic System Small Molecule, Dietary Supplement Alzheimer's Disease None
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Discontinued Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease Pain and Fever
Idalopirdine Lu AE58054,
SGS 518
3, Inactive Eli Lilly & Co., H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Idebenone Catena,
Sovrima
Discontinued Takeda Pharmaceutical Company Other Small Molecule Alzheimer's Disease None
JNJ-54861911 1 Janssen Amyloid-Related Small Molecule Alzheimer's Disease
Ladostigil Hemitartrate TV-3,326 2 Avraham Pharmaceuticals Ltd Cholinergic System Small Molecule Mild Cognitive Impairment
Levetiracetam Keppra 2, Discontinued GlaxoSmithKline (GSK), Otsuka Pharmaceutical Co., Ltd., UCB S.A. Amyloid-Related, Other Small Molecule Mild Cognitive Impairment, Parkinson's Disease Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Linopirdine DuP996 Discontinued Other Small Molecule Alzheimer's Disease None
Liraglutide Victoza™ 2 Novo Nordisk A/S Other Small Molecule Alzheimer's Disease
Lornoxicam Discontinued, Discontinued JSW Lifesciences Inflammation Small Molecule Alzheimer's Disease, Mild Cognitive Impairment Pain in US
LU25-109 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
LY2886721 β-secretase inhibitor Discontinued, Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
3, 3 AB Science Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
MEM 1003 BAY Z 4406 Discontinued, Discontinued, Discontinued, Discontinued Memory Pharmaceuticals Corporation Other Small Molecule Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, Bipolar Disorder None
Memantine Ebixa™,
Namenda™ ,
Axura®,
Akatinol®,
Memary®
Approved Forest Laboratories, Inc., H. Lundbeck, Merz Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease Alzheimer's Disease
Metrifonate trichlorfon Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
Milameline CI 979 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule Alzheimer's Disease None
Minocycline Solodyn,
Arestin,
Minocin,
Dynacin
2 Inflammation Small Molecule Alzheimer's Disease
MK-7622 2 Merck Unknown Small Molecule Alzheimer's Disease
MK-8931 MK-8931-009 ,
β-secretase inhibitor
3 Merck Amyloid-Related Small Molecule Alzheimer's Disease
MKC-231 Inactive Mitsubishi Tanabe Pharma Unknown Small Molecule Alzheimer's Disease None
MSDC-0160 Mitoglitazone 2 Metabolic Solutions Development Company Other Small Molecule Alzheimer's Disease
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Discontinued Procter & Gamble, Roche Inflammation Small Molecule Alzheimer's Disease Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness.
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin
2, 2, 2, 2 Amyloid-Related, Other Small Molecule, Other Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple System Atrophy Diabetes
Nefiracetam Discontinued Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule Alzheimer's Disease None
NeoTrofin AIT-082,
leteprinim
Discontinued NeoTherapeutics, Inc. Unknown Small Molecule Alzheimer's Disease None
Neramexane MRZ 2/579 Discontinued Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule Alzheimer's Disease None
NGX267 AF267B Inactive TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule Alzheimer's Disease None
NIC5-15 Pinitol,
D-Pinitol
2 Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Dietary Supplement Alzheimer's Disease
Nicotinamide Enduramide,
Niacinamide,
Nicotinic acid amide,
Vitamin B3
2 Other Small Molecule Alzheimer's Disease
Nilvadipine Nilvad,
Nivadil,
ARC029
3 Archer Pharmaceuticals, Inc. Other Small Molecule Alzheimer's Disease
NS2330 Tesofensine Discontinued NeuroSearch A/S Other Neurotransmitters Small Molecule Alzheimer's Disease
ORM-12741 2 Orion Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease
PBT2 PBT-2 2, 2 Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule Alzheimer's Disease, Huntington's Disease
PF-05212377 PF-5212377,
WYE-103760,
SAM-760
2 Pfizer Other Neurotransmitters Small Molecule Alzheimer's Disease
Phenserine Inactive TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule Alzheimer's Disease
Physostigmine Salicylate Synapton Discontinued Forest Laboratories, Inc. Cholinergic System Small Molecule Alzheimer's Disease
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
3 Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Mild Cognitive Impairment Type 2 diabetes mellitus
PQ912 1 Probiodrug AG Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
Prazosin Prazosin hydrochloride,
Minipress,
Hypovase,
Vasoflex
4 Other Neurotransmitters Small Molecule Alzheimer's Disease Hypertension
Prednisone Discontinued Inflammation Small Molecule Alzheimer's Disease
Propentofylline HWA 285,
PPF
Discontinued Unknown Small Molecule Alzheimer's Disease
PRX-03140 Potassium salt Inactive Epix Pharmaceuticals Other Small Molecule Alzheimer's Disease
R-pramipexole RPPX,
Dexpramipexole,
KNS-760704 ,
BIIB 050
2, Discontinued Biogen Idec, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Rember TM Methylene Blue,
Tau aggregation inhibitor (TAI),
TRx-0014
Discontinued TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Resveratrol trans-3,4',5-trihydroxystilbene 3, 4, Not Regulated Other Small Molecule, Dietary Supplement Alzheimer's Disease, Mild Cognitive Impairment,
RG1577 RO4602522 2 Evotech AG, Roche Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
RG3487 RO5313534,
MEM 3454
Inactive Roche Cholinergic System Small Molecule Alzheimer's Disease
RG7129 RO5508887,
BACE1 Inhibitor
Discontinued Roche Amyloid-Related Small Molecule Alzheimer's Disease
Rilapladib SB-659032 2 GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
Riluzole Rilutek®,
RP 54274
2, Discontinued, Approved, Discontinued Sanofi Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Huntington's Disease Amyotrophic Lateral Sclerosis in many countries
Rivastigmine Exelon™,
Rivastigmine tartrate ,
Rivastach® Patch,
Prometax®,
SDZ ENA 713
Approved, Approved Novartis Pharmaceuticals Corporation Cholinergic System Small Molecule Alzheimer's Disease, Parkinson's Disease Dementia Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease
Rofecoxib Vioxx™ Discontinued Merck Inflammation Small Molecule Alzheimer's Disease Withdrawn from market
Rosiglitazone Rosiglitazone maleate Discontinued GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
Sabeluzole R58735 Inactive Unknown Small Molecule Alzheimer's Disease
SAR110894D 2 Sanofi Other Small Molecule Alzheimer's Disease
SB 202026 Memric Discontinued Other Neurotransmitters Small Molecule Alzheimer's Disease
SB-742457 GSK 742457 Inactive, 2 GlaxoSmithKline (GSK) Other Neurotransmitters Small Molecule Alzheimer's Disease, Dementia
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease None
SGS-742 CGP-36742,
DVD-742
Discontinued Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease
Simvastatin Zocor®,
Lipex®,
Lipovas®,
Denan®
Inactive, 4 Merck Cholesterol Small Molecule Alzheimer's Disease, Mild Cognitive Impairment Hypercholesterolemia and diabetic cardiomyopathy.
ST101 ZSET1446 Inactive Sonexa Therapeutics, Inc. Unknown Small Molecule Alzheimer's Disease
Suritozole MD 26479 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
T-817MA T 817MA, T817MA 2 Toyama Chemical Co., Ltd. Other, Unknown Small Molecule Alzheimer's Disease
Tacrine Cognex™ Approved Pfizer, Shionogi Pharma Cholinergic System Small Molecule Alzheimer's Disease
Thalidomide Thalomid® 2/3 Celgene Corporation Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Discontinued, Discontinued Zeltia Group Tau Small Molecule Alzheimer's Disease, Progressive Supranuclear Palsy
TPI 287 1, 1, 1 Cortice Biosciences Tau Small Molecule Alzheimer's Disease, Corticobasal Degeneration, Progressive Supranuclear Palsy
TRx0237 LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
3, 3 TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease, Frontotemporal Dementia Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
TTP488 PF-04494700 ,
RAGE Inhibitor
Inactive Pfizer, TransTech Pharma, Inc. Amyloid-Related Small Molecule Alzheimer's Disease
Valproate Depakote,
Depakene,
Valproic acid ,
Divalproex sodium
Inactive Abbott Laboratories Other Neurotransmitters Small Molecule Alzheimer's Disease Epilepsy, Bipolar disorder, Migraine
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Discontinued Pfizer Cholinergic System Small Molecule Alzheimer's Disease Smoking cessation