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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
3, 3 TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease, Frontotemporal Dementia Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Neflamapomid VX-745 2 EIP Pharma, LLC Inflammation Small Molecule Alzheimer's Disease
ABT 418 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
ABT-089 Discontinued Abbott Laboratories Cholinergic System Small Molecule Alzheimer's Disease
ABT-288 Discontinued AbbVie Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
ABT-384 Discontinued AbbVie Other Small Molecule Alzheimer's Disease
ABT-957 1 AbbVie Other Small Molecule Alzheimer's Disease
AF 102B cevimeline HCL,
Evoxac™
Discontinued SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Alzheimer's Disease Treatment of dry mouth in Sjogren's syndrome.
AGB101 Levetiracetam,
Keppra
2, Discontinued AgeneBio, Inc. Amyloid-Related, Other Small Molecule Mild Cognitive Impairment, Parkinson's Disease Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
3 AZTherapies, Inc. Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
AVP-786 3, 2 Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
AVP-923 Nuedexta,
Zenvia
4, 3, 3 Avanir Pharmaceuticals Other Neurotransmitters Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Parkinson's Disease
AZD1446 TC-6683 Discontinued AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease None
AZD3293 LY3314814,
BACE inhibitor
3 AstraZeneca, Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease
AZD3480 ispronicline,
TC-1734
Inactive AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease
Acitretin Soriatane ,
Neotigason,
RO 101670
2 Actavis, Allergan plc Amyloid-Related Small Molecule Alzheimer's Disease Psoriasis in US
Allopregnanolone 3α,5α-tetrahydroprogesterone,
3α-hydroxy-5α-pregnan-20-one
1 Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
Anavex 2-73 2 Anavex Life Science Corp. Other Small Molecule Alzheimer's Disease
Aripiprazole Abilify,
BMS-337039
3, Approved Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Atomoxetine ATX,
Strattera
Discontinued Eli Lilly & Co. Other Neurotransmitters Small Molecule Alzheimer's Disease ADHD in US
Atorvastatin Lipitor™ ,
Zarator®,
Sortis®,
Tahor®
Inactive Pfizer Cholesterol Small Molecule Alzheimer's Disease Hypercholesterolaemia
Avagacestat BMS-708163 Discontinued Bristol-Myers Squibb Amyloid-Related Small Molecule Alzheimer's Disease
Azeliragon PF-04494700 ,
TTP488
3 Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
BI 1181181 VTP 37948,
BACE inhibitor
Discontinued Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule Alzheimer's Disease
BI 409306 SUB 166499 2 Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
Besipirdine HCl HP 749 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
Bexarotene Targretin® 2 Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Alzheimer's Disease Cutaneous T-cell Lymphoma in US
Brexpiprazole Rexulti,
OPC 34712
3, Approved H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
CHF 5074 2, Inactive CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule Mild Cognitive Impairment, Alzheimer's Disease
CNP520 BACE Inhibitor 2/3 Amgen, Inc., Novartis Pharmaceuticals Corporation Amyloid-Related Small Molecule Alzheimer's Disease
CT1812 1/2 Cognition Therapeutics Inc. Amyloid-Related Small Molecule Alzheimer's Disease
CX516 Ampalex Discontinued Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease None
Carvedilol Coreg,
Artist ,
Aucardic,
Dilatrend,
Kredex
4 Procter & Gamble Unknown Small Molecule Alzheimer's Disease Hypertension, heart failure, angina pectoris
Celecoxib Celebrex Discontinued Pfizer Inflammation Small Molecule Alzheimer's Disease Pain, Arthritis
Circadin 2 Neurim Pharmaceuticals Ltd. Other Small Molecule Alzheimer's Disease Insomnia
Clioquinol iodochlorhydroxyquin,
PBT-1
Discontinued Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule Alzheimer's Disease
Dapsone Avlosulfon,
Diaminodiphenylsulfone,
DDS
Inactive Immune Network Ltd. Other Small Molecule Alzheimer's Disease Leprosy, malaria, some bacterial skin infections
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
2, Discontinued Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Discontinued, Discontinued Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Alzheimer's Disease, Huntington's Disease Anti-histamine use in Russia
Donepezil Aricept™,
Donepezil hydrochloride,
Eranz®,
E 2020
Approved, 3, 2, 3 Eisai Co., Ltd., Pfizer Cholinergic System Small Molecule Alzheimer's Disease, Dementia with Lewy Bodies, Down's Syndrome, Parkinson's Disease Dementia Alzheimer's Disease
E2609 BACE inhibitor 3 Biogen, Eisai Co., Ltd. Amyloid-Related Small Molecule Alzheimer's Disease
EHT 0202 Etazolate 2 ExonHit Therapeutics Other Small Molecule Alzheimer's Disease None
ELND005 AZD-103,
Scyllo-inositol,
cyclohexane-1,2,3,4,5,6-hexol
2 Elan Corporation, Speranza Therapeutics, Transition Therapeutics, Inc. Amyloid-Related Small Molecule Alzheimer's Disease None
EVP-0962 EVP 0015962 2, 2 FORUM Pharmaceuticals Inc. Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
Discontinued, Discontinued FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma Cholinergic System Small Molecule Alzheimer's Disease, Schizophrenia None
Epothilone D BMS-241027 Discontinued Bristol-Myers Squibb Tau Small Molecule Alzheimer's Disease
Eptastigmine MF 201 Discontinued Mediolanum Cholinergic System Small Molecule Alzheimer's Disease None
Exendin-4 Exenatide,
Byetta,
Bydureon
2 Other Small Molecule Alzheimer's Disease Diabetes mellitus in US
FRM-0334 EVP-0334 2 FORUM Pharmaceuticals Inc. Other Small Molecule Frontotemporal Dementia
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Discontinued Myriad Genetics & Laboratories Amyloid-Related Small Molecule Alzheimer's Disease None
G-CSF Filgrastim 2 Other Small Molecule Alzheimer's Disease Neutropenia in US
GC 021109 1 GliaCure Inflammation Small Molecule Alzheimer's Disease
GLN-1062 Memogain 1 Galantos Pharma, Neurodyn Cholinergic System Small Molecule Alzheimer's Disease
GSK239512 Discontinued GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
GSK2647544 GSK-2647544 1 GlaxoSmithKline (GSK) Cholesterol Small Molecule Alzheimer's Disease
Galantamine Razadyne™,
Reminyl™,
Nivalin®
Approved Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company Cholinergic System Small Molecule Alzheimer's Disease Mild to Moderate Alzheimer's disease
Gemfibrozil Lopid,
Jezil,
Gen-Fibro
0 Cholesterol Small Molecule Alzheimer's Disease Hyperlipidemia
HF0220 Discontinued Newron Inflammation Small Molecule Alzheimer's Disease
Huperzine A ZT-1,
DEBIO 9902 ,
Qian ceng ta,
Cerebra capsule,
Pharmassure Memorall capsule
Inactive Debiopharm Group™, Neuro-Hitech, Inc. Cholinergic System Small Molecule, Dietary Supplement Alzheimer's Disease None
ITI-007 3, 3, 3 Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia, Bipolar Disorder
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Discontinued Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease Pain and Fever
Idalopirdine Lu AE58054,
SGS 518
3, Inactive H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Idebenone Catena,
Sovrima
Discontinued Takeda Pharmaceutical Company Other Small Molecule Alzheimer's Disease None
Intepirdine RVT-101,
SB-742457 ,
GSK 742457
2, 2 Axovant Sciences Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Dementia with Lewy Bodies
JNJ-54861911 BACE inhibitor 2/3 Janssen, Shionogi Pharma Amyloid-Related Small Molecule Alzheimer's Disease
LU25-109 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
LY2886721 BACE inhibitor Discontinued, Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
LY3202626 BACE Inhibitor 2 Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease
Ladostigil Ladostigil hemitartrate,
TV3326
2, Discontinued Avraham Pharmaceuticals Ltd Cholinergic System Small Molecule Mild Cognitive Impairment, Alzheimer's Disease
Linopirdine DuP996 Discontinued Other Small Molecule Alzheimer's Disease None
Liraglutide Victoza™ 2 Novo Nordisk A/S Other Small Molecule Alzheimer's Disease
Lornoxicam Discontinued, Discontinued JSW Lifesciences Inflammation Small Molecule Alzheimer's Disease, Mild Cognitive Impairment Pain in US
MEM 1003 BAY Z 4406 Discontinued, Discontinued, Discontinued, Discontinued Memory Pharmaceuticals Corporation Other Small Molecule Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, Bipolar Disorder None
MK-7622 Discontinued Merck Unknown Small Molecule Alzheimer's Disease
MKC-231 Inactive Mitsubishi Tanabe Pharma Unknown Small Molecule Alzheimer's Disease None
MSDC-0160 Mitoglitazone 2 Metabolic Solutions Development Company Other Small Molecule Alzheimer's Disease
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
3, 3 AB Science Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Memantine Ebixa™,
Namenda™ ,
Axura®,
Akatinol®,
Memary®
Approved Forest Laboratories, Inc., H. Lundbeck, Merz Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease Alzheimer's Disease
Metrifonate trichlorfon Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
Milameline CI 979 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule Alzheimer's Disease None
Minocycline Solodyn,
Arestin,
Minocin,
Dynacin
2 Inflammation Small Molecule Alzheimer's Disease
NGX267 AF267B Inactive TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule Alzheimer's Disease None
NIC5-15 Pinitol,
D-Pinitol
2 Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Dietary Supplement Alzheimer's Disease
NS2330 Tesofensine Discontinued NeuroSearch A/S Other Neurotransmitters Small Molecule Alzheimer's Disease
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Discontinued Procter & Gamble Inflammation Small Molecule Alzheimer's Disease Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness.
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin
2/3, 2, 2, 2 Amyloid-Related, Other Small Molecule, Other Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple System Atrophy Diabetes
Nefiracetam Discontinued Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule Alzheimer's Disease None
Nelonicline ABT-126 Discontinued, Inactive AbbVie Cholinergic System Small Molecule Alzheimer's Disease, Schizophrenia
Nelotanserin APD-125 2 Axovant Sciences Ltd. Other Neurotransmitters Small Molecule Dementia with Lewy Bodies
NeoTrofin AIT-082,
leteprinim
Discontinued NeoTherapeutics, Inc. Unknown Small Molecule Alzheimer's Disease None
Neramexane MRZ 2/579 Discontinued Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule Alzheimer's Disease None
Nicotinamide Enduramide,
Niacinamide,
Nicotinic acid amide,
Vitamin B3
2 Other Small Molecule Alzheimer's Disease
Nilvadipine Nilvad,
Nivadil,
ARC029
3 Archer Pharmaceuticals, Inc. Other Small Molecule Alzheimer's Disease
Nimodipine Nimotop 1 Bayer Metals Small Molecule Frontotemporal Dementia Subarachnoid hemorrhage
ORM-12741 2 Orion Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease
PBT2 PBT-2 2, 2 Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule Alzheimer's Disease, Huntington's Disease
PF-05212377 PF-5212377,
WYE-103760,
SAM-760
Inactive Pfizer Other Neurotransmitters Small Molecule Alzheimer's Disease
PF-05251749 1 Pfizer Unknown Small Molecule Alzheimer's Disease
PF-06648671 1 Pfizer Amyloid-Related Small Molecule Alzheimer's Disease
PF-06751979 1 Pfizer Unknown Small Molecule Alzheimer's Disease
PQ912 2 Probiodrug AG Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
PRX-03140 Potassium salt Inactive Epix Pharmaceuticals Other Small Molecule Alzheimer's Disease
Phenserine Inactive TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule Alzheimer's Disease
Physostigmine Salicylate Synapton Discontinued Forest Laboratories, Inc. Cholinergic System Small Molecule Alzheimer's Disease
Pimavanserin Nuplazid,
ACP-103,
Pimavanserin tartrate
2, 3 Acadia Pharmaceuticals Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia Parkinson's psychosis
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
3 Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Mild Cognitive Impairment Type 2 diabetes mellitus
Piromelatine Neu-P11 2 Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
Prazosin Prazosin hydrochloride,
Minipress,
Hypovase,
Vasoflex
4 Other Neurotransmitters Small Molecule Alzheimer's Disease Hypertension
Prednisone Discontinued Inflammation Small Molecule Alzheimer's Disease
Propentofylline HWA 285,
PPF
Discontinued Unknown Small Molecule Alzheimer's Disease
RG3487 RO5313534,
MEM 3454
Inactive Roche Cholinergic System Small Molecule Alzheimer's Disease
RG7129 RO5508887,
BACE Inhibitor
Discontinued Roche Amyloid-Related Small Molecule Alzheimer's Disease
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Discontinued TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Resveratrol trans-3,4',5-trihydroxystilbene 3, 4 Other Small Molecule, Dietary Supplement Alzheimer's Disease, Mild Cognitive Impairment
Rilapladib SB-659032 2 GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
Riluzole Rilutek®,
RP 54274
2, Discontinued, Approved, Discontinued Sanofi Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Huntington's Disease Amyotrophic Lateral Sclerosis in many countries
Rivastigmine Exelon™,
Rivastigmine tartrate ,
Rivastach® Patch,
Prometax®,
SDZ ENA 713
Approved, Approved Novartis Pharmaceuticals Corporation Cholinergic System Small Molecule Alzheimer's Disease, Parkinson's Disease Dementia Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease
Rofecoxib Vioxx™ Discontinued Merck Inflammation Small Molecule Alzheimer's Disease Withdrawn from market
Rosiglitazone Rosiglitazone maleate,
Avandia
Discontinued GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
S 38093 Discontinued Servier Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
S-Equol Aus-131 1 Ausio Pharmaceuticals, LLC Other Small Molecule Alzheimer's Disease
S47445 CX1632 2 Cortex Pharmaceuticals, Inc., Servier Other Neurotransmitters Small Molecule Alzheimer's Disease
SAR110894D 2 Sanofi Other Small Molecule Alzheimer's Disease
SB 202026 Memric Discontinued Other Neurotransmitters Small Molecule Alzheimer's Disease
SGS-742 CGP-36742,
DVD-742
Discontinued Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease
ST101 ZSET1446 Inactive Sonexa Therapeutics, Inc. Unknown Small Molecule Alzheimer's Disease
SUVN-502 2 Suven Life Sciences Ltd Other Neurotransmitters Small Molecule Alzheimer's Disease
SUVN-G3031 1 Suven Life Sciences Ltd Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
Sabeluzole R58735 Inactive Unknown Small Molecule Alzheimer's Disease
Saracatinib AZD0530 2 AstraZeneca Other Small Molecule Alzheimer's Disease
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease None
Sembragiline RO4602522,
RG1577
Discontinued Evotech AG, Roche Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
Simvastatin Zocor®,
Lipex®,
Lipovas®,
Denan®
Inactive, 4 Merck Cholesterol Small Molecule Alzheimer's Disease, Mild Cognitive Impairment Hypercholesterolemia and diabetic cardiomyopathy.
Suritozole MD 26479 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
T-817MA T 817MA, T817MA 2 Toyama Chemical Co., Ltd. Other, Unknown Small Molecule Alzheimer's Disease
T3D-959 DB959 2 T3D Therapeutics, Inc. Other Small Molecule Alzheimer's Disease
TPI 287 1, 1, 1 Cortice Biosciences Tau Small Molecule Alzheimer's Disease, Corticobasal Degeneration, Progressive Supranuclear Palsy
Tacrine Cognex™ Approved Pfizer, Shionogi Pharma Cholinergic System Small Molecule Alzheimer's Disease
Telmisartan Micardis 2 Boehringer Ingelheim Other Small Molecule Alzheimer's Disease Hypertension
Thalidomide Thalomid® 2/3 Celgene Corporation Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Discontinued, Discontinued Zeltia Group Tau Small Molecule Alzheimer's Disease, Progressive Supranuclear Palsy
Valproate Depakote,
Depakene,
Valproic acid ,
Divalproex sodium
Inactive Abbott Laboratories Other Neurotransmitters Small Molecule Alzheimer's Disease Epilepsy, Bipolar disorder, Migraine
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Discontinued Pfizer Cholinergic System Small Molecule Alzheimer's Disease Smoking cessation
Verubecestat MK-8931, MK-8931-009 ,
BACE inhibitor
3 Merck Amyloid-Related Small Molecule Alzheimer's Disease
Xaliproden SR 57746A Discontinued Sanofi Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
XanamemTM UE 2343 2 Actinogen Medical Other Small Molecule Alzheimer's Disease