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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
3, 3 TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease, Frontotemporal Dementia Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
AADvac-1 Axon peptide 108 conjugated to KLH 2 Axon Neuroscience SE Tau Immunotherapy (active) Alzheimer's Disease
ACI-35 1 AC Immune SA, Janssen Tau Immunotherapy (active) Alzheimer's Disease
BMS-986168 IPN007 1 Bristol-Myers Squibb Tau Immunotherapy (passive) Progressive Supranuclear Palsy
C2N 8E12 ABBV-8E12 1, 2 AbbVie, C2N Diagnostics, LLC Tau Immunotherapy (passive) Progressive Supranuclear Palsy, Alzheimer's Disease
Davunetide NAP,
AL-108
Inactive, Inactive, Inactive, Inactive Allon Therapeutics Inc., Paladin Labs Inc. Tau Other Mild Cognitive Impairment, Progressive Supranuclear Palsy, Schizophrenia, Frontotemporal Dementia
Epothilone D BMS-241027 Discontinued Bristol-Myers Squibb Tau Small Molecule Alzheimer's Disease
RG7345 RO6926496 Discontinued Roche Tau Immunotherapy (passive) Alzheimer's Disease
RO 7105705 RG 6100 1 AC Immune SA, Genentech, Hoffmann-La Roche Tau Immunotherapy (passive) Alzheimer's Disease
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Discontinued TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
TPI 287 1, 1, 1 Cortice Biosciences Tau Small Molecule Alzheimer's Disease, Corticobasal Degeneration, Progressive Supranuclear Palsy
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Discontinued, Discontinued Zeltia Group Tau Small Molecule Alzheimer's Disease, Progressive Supranuclear Palsy