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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
ABT-288 Discontinued AbbVie Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
AVP-786 3, 2 Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
AVP-923 Nuedexta,
Zenvia
4, 3, 3 Avanir Pharmaceuticals Other Neurotransmitters Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Parkinson's Disease
Allopregnanolone 3α,5α-tetrahydroprogesterone,
3α-hydroxy-5α-pregnan-20-one
1 Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
Aripiprazole Abilify,
BMS-337039
3, Approved Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Atomoxetine ATX,
Strattera
Discontinued Eli Lilly & Co. Other Neurotransmitters Small Molecule Alzheimer's Disease ADHD in US
BI 409306 SUB 166499 2 Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
Besipirdine HCl HP 749 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
Brexpiprazole Rexulti,
OPC 34712
3, Approved H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
CX516 Ampalex Discontinued Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease None
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
2, Discontinued Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Discontinued, Discontinued Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Alzheimer's Disease, Huntington's Disease Anti-histamine use in Russia
GSK239512 Discontinued GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
ITI-007 3, 3, 3 Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia, Bipolar Disorder
Idalopirdine Lu AE58054,
SGS 518
3, Inactive H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Intepirdine RVT-101,
SB-742457 ,
GSK 742457
3, 2/3 Axovant Sciences Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Dementia with Lewy Bodies
Memantine Ebixa™,
Namenda™ ,
Axura®,
Akatinol®,
Memary®
Approved Forest Laboratories, Inc., H. Lundbeck, Merz Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease Alzheimer's Disease
NS2330 Tesofensine Discontinued NeuroSearch A/S Other Neurotransmitters Small Molecule Alzheimer's Disease
Nelotanserin APD-125 2 Axovant Sciences Ltd. Other Neurotransmitters Small Molecule Dementia with Lewy Bodies
Neramexane MRZ 2/579 Discontinued Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule Alzheimer's Disease None
ORM-12741 2 Orion Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease
PF-05212377 PF-5212377,
WYE-103760,
SAM-760
Inactive Pfizer Other Neurotransmitters Small Molecule Alzheimer's Disease
PXT864 PXT00864 2 Pharnext Other Neurotransmitters Small Molecule Alzheimer's Disease
Pimavanserin Nuplazid,
ACP-103,
Pimavanserin tartrate
2, 3 Acadia Pharmaceuticals Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia Parkinson's psychosis
Piromelatine Neu-P11 2 Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
Prazosin Prazosin hydrochloride,
Minipress,
Hypovase,
Vasoflex
4 Other Neurotransmitters Small Molecule Alzheimer's Disease Hypertension
Riluzole Rilutek®,
RP 54274
2, Discontinued, Approved, Discontinued Sanofi Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Huntington's Disease Amyotrophic Lateral Sclerosis in many countries
S 38093 Discontinued Servier Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
S47445 CX1632 2 Cortex Pharmaceuticals, Inc., Servier Other Neurotransmitters Small Molecule Alzheimer's Disease
SB 202026 Memric Discontinued Other Neurotransmitters Small Molecule Alzheimer's Disease
SGS-742 CGP-36742,
DVD-742
Discontinued Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease
SUVN-502 2 Suven Life Sciences Ltd Other Neurotransmitters Small Molecule Alzheimer's Disease
SUVN-G3031 1 Suven Life Sciences Ltd Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
Sembragiline RO4602522,
RG1577
Discontinued Evotech AG, Roche Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
Suritozole MD 26479 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
Valproate Depakote,
Depakene,
Valproic acid ,
Divalproex sodium
Inactive Abbott Laboratories Other Neurotransmitters Small Molecule Alzheimer's Disease Epilepsy, Bipolar disorder, Migraine
Xaliproden SR 57746A Discontinued Sanofi Other Neurotransmitters, Other Small Molecule Alzheimer's Disease