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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
AAB-003 PF-05236812 1 Janssen, Pfizer Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
ACI-24 Pal1-15 acetate salt 1/2, 1 AC Immune SA Amyloid-Related Immunotherapy (active) Alzheimer's Disease, Down's Syndrome
AGB101 Levetiracetam,
Keppra
2, Discontinued AgeneBio, Inc. Amyloid-Related, Other Small Molecule Mild Cognitive Impairment, Parkinson's Disease Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
3 AZTherapies, Inc. Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
AN-1792 AIP 001 Discontinued Janssen, Pfizer Amyloid-Related Immunotherapy (active) Alzheimer's Disease None
AZD3293 LY3314814,
BACE inhibitor
3 AstraZeneca, Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease
Acitretin Soriatane ,
Neotigason,
RO 101670
2 Actavis, Allergan plc Amyloid-Related Small Molecule Alzheimer's Disease Psoriasis in US
Aducanumab BIIB037 3 Biogen Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
Affitope AD02 2 AFFiRiS AG Amyloid-Related Immunotherapy (active) Alzheimer's Disease
Alzhemed™ Vivimind™,
Tramiprosate,
NC-531,
homotaurine,
3-APS
Inactive Neurochem, Inc. Amyloid-Related Dietary Supplement Alzheimer's Disease None
Avagacestat BMS-708163 Discontinued Bristol-Myers Squibb Amyloid-Related Small Molecule Alzheimer's Disease
Azeliragon PF-04494700 ,
TTP488
3 Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
BAN2401 2 Biogen, Eisai Co., Ltd. Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
BI 1181181 VTP 37948,
BACE inhibitor
Discontinued Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule Alzheimer's Disease
Bapineuzumab AAB-001 Discontinued Janssen, Pfizer Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
Bexarotene Targretin® 2 Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Alzheimer's Disease Cutaneous T-cell Lymphoma in US
CAD106 2/3 Novartis Pharmaceuticals Corporation Amyloid-Related Immunotherapy (active) Alzheimer's Disease None
CHF 5074 2, Inactive CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule Mild Cognitive Impairment, Alzheimer's Disease
CNP520 BACE Inhibitor 2/3 Amgen, Inc., Novartis Pharmaceuticals Corporation Amyloid-Related Small Molecule Alzheimer's Disease
CT1812 1 Cognition Therapeutics Inc. Amyloid-Related Small Molecule Alzheimer's Disease
Clioquinol iodochlorhydroxyquin,
PBT-1
Discontinued Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule Alzheimer's Disease
Crenezumab MABT5102A ,
RG7412
3 Genentech Amyloid-Related Immunotherapy (passive) Alzheimer's Disease None
E2609 BACE inhibitor 2 Biogen, Eisai Co., Ltd. Amyloid-Related Small Molecule Alzheimer's Disease
ELND005 AZD-103,
Scyllo-inositol,
cyclohexane-1,2,3,4,5,6-hexol
2 Elan Corporation, Speranza Therapeutics, Transition Therapeutics, Inc. Amyloid-Related Small Molecule Alzheimer's Disease None
EVP-0962 EVP 0015962 2, 2 FORUM Pharmaceuticals Inc. Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
Epigallocatechin Gallate (EGCG) Sunphenon EGCg 2/3, 2, 3 Taiyo International Amyloid-Related, Inflammation, Other Dietary Supplement Alzheimer's Disease, Down's Syndrome, Multiple System Atrophy
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Discontinued Myriad Genetics & Laboratories Amyloid-Related Small Molecule Alzheimer's Disease None
GSK933776 Inactive GlaxoSmithKline (GSK) Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
Gammagard® Intravenous Immunoglobulin,
IVIg
Discontinued Baxter Healthcare Amyloid-Related, Inflammation Immunotherapy (passive) Alzheimer's Disease Immunodeficiency conditions
Gamunex Intravenous Immunoglobulin,
Human Albumin Combined With Flebogamma
2/3 Grifols Biologicals Inc. Amyloid-Related, Inflammation Immunotherapy (passive) Alzheimer's Disease Immunodeficiency, chronic inflammatory demyelinating neuropathy
Gantenerumab RO4909832,
RG1450
3 Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Discontinued Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease Pain and Fever
JNJ-54861911 BACE inhibitor 2/3 Janssen, Shionogi Pharma Amyloid-Related Small Molecule Alzheimer's Disease
LY2886721 BACE inhibitor Discontinued, Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
LY3002813 N3pG-Aβ Monoclonal Antibody 1 Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
MEDI1814 1 AstraZeneca Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
NIC5-15 Pinitol,
D-Pinitol
2 Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Dietary Supplement Alzheimer's Disease
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin
2, 2, 2, 2 Amyloid-Related, Other Small Molecule, Other Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple System Atrophy Diabetes
Octagam®10% Intravenous Immunoglobulin,
NewGam
Inactive, Inactive Octapharma Amyloid-Related, Inflammation Immunotherapy (passive) Alzheimer's Disease, Mild Cognitive Impairment Immunodeficiency disorders
PBT2 PBT-2 2, 2 Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule Alzheimer's Disease, Huntington's Disease
PF-06648671 1 Pfizer Amyloid-Related Small Molecule Alzheimer's Disease
PQ912 2 Probiodrug AG Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
Ponezumab PF-04360365 Discontinued, 2 Pfizer Amyloid-Related Immunotherapy (passive) Alzheimer's Disease, Cerebral Amyloid Angiopathy None
RG7129 RO5508887,
BACE Inhibitor
Discontinued Roche Amyloid-Related Small Molecule Alzheimer's Disease
SAR228810 1 Sanofi Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease None
Solanezumab LY2062430 3 Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) Alzheimer's Disease None
Thalidomide Thalomid® 2/3 Celgene Corporation Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
Vanutide cridificar ACC-001,
PF-05236806
Discontinued Janssen Amyloid-Related Immunotherapy (active) Alzheimer's Disease None
Verubecestat MK-8931, MK-8931-009 ,
BACE inhibitor
3 Merck Amyloid-Related Small Molecule Alzheimer's Disease