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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Phase 3), Frontotemporal Dementia (Phase 3) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
AADvac-1 Axon peptide 108 conjugated to KLH Alzheimer's Disease (Phase 2) Axon Neuroscience SE Tau Immunotherapy (active)
ACI-35 Alzheimer's Disease (Phase 1) AC Immune SA, Janssen Tau Immunotherapy (active)
BIIB092 BMS-986168, IPN007 Progressive Supranuclear Palsy (Phase 1) Biogen, Bristol-Myers Squibb Tau Immunotherapy (passive)
C2N 8E12 ABBV-8E12 Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 2) AbbVie, C2N Diagnostics, LLC Tau Immunotherapy (passive)
Davunetide NAP,
AL-108
Mild Cognitive Impairment (Inactive), Progressive Supranuclear Palsy (Inactive), Schizophrenia (Inactive), Frontotemporal Dementia (Inactive) Allon Therapeutics Inc., Paladin Labs Inc. Tau Other
Epothilone D BMS-241027 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Tau Small Molecule
RG7345 RO6926496 Alzheimer's Disease (Discontinued) Roche Tau Immunotherapy (passive)
RO 7105705 RG 6100 Alzheimer's Disease (Phase 1) AC Immune SA, Genentech, Hoffmann-La Roche Tau Immunotherapy (passive)
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Discontinued) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
TPI 287 Alzheimer's Disease (Phase 1), Corticobasal Degeneration (Phase 1), Progressive Supranuclear Palsy (Phase 1) Cortice Biosciences Tau Small Molecule
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) Zeltia Group Tau Small Molecule