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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
ABT-288 Alzheimer's Disease (Discontinued) AbbVie Cholinergic System, Other Neurotransmitters Small Molecule
AVP-786 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 2) Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
AVP-923 Nuedexta,
Zenvia
Alzheimer's Disease (Phase 4), Amyotrophic Lateral Sclerosis (Phase 3), Parkinson's Disease (Phase 3) Avanir Pharmaceuticals Other Neurotransmitters Small Molecule
Allopregnanolone 3α,5α-tetrahydroprogesterone,
3α-hydroxy-5α-pregnan-20-one
Alzheimer's Disease (Phase 1) Other Neurotransmitters, Other Small Molecule
Aripiprazole Abilify,
BMS-337039
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Atomoxetine ATX,
Strattera
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Other Neurotransmitters Small Molecule ADHD in US
BI 409306 SUB 166499 Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule
Besipirdine HCl HP 749 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
Brexpiprazole Rexulti,
OPC 34712
Alzheimer's Disease (Phase 3), Schizophrenia (Approved) H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
CX516 Ampalex Alzheimer's Disease (Discontinued) Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule None
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Anti-histamine use in Russia
GSK239512 Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule
ITI-007 Alzheimer's Disease (Phase 3), Schizophrenia (Phase 3), Bipolar Disorder (Phase 3) Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. Other Neurotransmitters Small Molecule
Idalopirdine Lu AE58054,
SGS 518
Alzheimer's Disease (Phase 3), Schizophrenia (Inactive) H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule
Intepirdine RVT-101,
SB 742457 ,
GSK 742457
Alzheimer's Disease (Phase 3), Dementia with Lewy Bodies (Phase 2/3) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
Memantine Ebixa™,
Namenda™ ,
Axura®,
Akatinol®,
Memary®
Alzheimer's Disease (Approved) Forest Laboratories, Inc., H. Lundbeck, Merz Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease
NS2330 Tesofensine Alzheimer's Disease (Discontinued) NeuroSearch A/S Other Neurotransmitters Small Molecule
Nelotanserin APD-125 Dementia with Lewy Bodies (Phase 2) Axovant Sciences Ltd. Other Neurotransmitters Small Molecule
Neramexane MRZ 2/579 Alzheimer's Disease (Discontinued) Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule None
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
PF-05212377 PF-5212377,
WYE-103760,
SAM-760
Alzheimer's Disease (Inactive) Pfizer Other Neurotransmitters Small Molecule
PXT864 PXT00864 Alzheimer's Disease (Phase 2) Pharnext Other Neurotransmitters Small Molecule
Pimavanserin Nuplazid,
ACP-103,
Pimavanserin tartrate
Alzheimer's Disease (Phase 2), Schizophrenia (Phase 3) Acadia Pharmaceuticals Other Neurotransmitters Small Molecule Parkinson's psychosis
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Prazosin Prazosin hydrochloride,
Minipress,
Hypovase,
Vasoflex
Alzheimer's Disease (Phase 4) Other Neurotransmitters Small Molecule Hypertension
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
S 38093 Alzheimer's Disease (Discontinued) Servier Cholinergic System, Other Neurotransmitters Small Molecule
S47445 CX1632 Alzheimer's Disease (Phase 2) Cortex Pharmaceuticals, Inc., Servier Other Neurotransmitters Small Molecule
SB 202026 Memric Alzheimer's Disease (Discontinued) Other Neurotransmitters Small Molecule
SGS-742 CGP-36742,
DVD-742
Alzheimer's Disease (Discontinued) Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule
SUVN-502 Alzheimer's Disease (Phase 2) Suven Life Sciences Ltd Other Neurotransmitters Small Molecule
SUVN-G3031 Alzheimer's Disease (Phase 1) Suven Life Sciences Ltd Cholinergic System, Other Neurotransmitters Small Molecule
Sembragiline RO4602522,
RG1577
Alzheimer's Disease (Discontinued) Evotech AG, Roche Other Neurotransmitters, Other Small Molecule
Suritozole MD 26479 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
Valproate Depakote,
Depakene,
Valproic acid ,
Divalproex sodium
Alzheimer's Disease (Inactive) Abbott Laboratories Other Neurotransmitters Small Molecule Epilepsy, Bipolar disorder, Migraine
Xaliproden SR 57746A Alzheimer's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule