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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
ABT-384 Alzheimer's Disease (Discontinued) AbbVie Other Small Molecule
ABT-957 Alzheimer's Disease (Phase 1) AbbVie Other Small Molecule
AC-1204 Caprylic triglyceride,
Long-chain triglycerides
Alzheimer's Disease (Phase 2/3) Accera, Inc. Other Other None
AGB101 Levetiracetam,
Keppra
Mild Cognitive Impairment (Phase 3), Parkinson's Disease (Discontinued) AgeneBio, Inc. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Acetyl-l-carnitine HCI ALCAR Alzheimer's Disease (Discontinued) Sigma-Tau Pharmaceuticals Other Dietary Supplement
Allopregnanolone 3α,5α-tetrahydroprogesterone,
3α-hydroxy-5α-pregnan-20-one
Alzheimer's Disease (Phase 1) Other Neurotransmitters, Other Small Molecule
Alpha-Tocopherol Vitamin E Alzheimer's Disease (Phase 3) Other Dietary Supplement
Anavex 2-73 Alzheimer's Disease (Phase 2) Anavex Life Science Corp. Other Small Molecule
BI 409306 SUB 166499 Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule
CERE-110 Nerve Growth Factor gene therapy Alzheimer's Disease (Discontinued) Sangamo BioSciences, Inc. Other Gene/Stem Cell
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
COGNIShunt™ Alzheimer's Disease (Inactive) Other Procedural Intervention None
Cerebrolysin Alzheimer's Disease (Phase 2) Ebewe Pharmaceutical Other Other
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
Curcumin diferuloylmethane,
Longvida™
Alzheimer's Disease (Phase 2) Verdure Sciences Other, Unknown Dietary Supplement None
Dapsone Avlosulfon,
Diaminodiphenylsulfone,
DDS
Alzheimer's Disease (Inactive) Immune Network Ltd. Other Small Molecule Leprosy, malaria, some bacterial skin infections
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Docosahexaenoic acid (DHA) Omega 3 fatty acid Alzheimer's Disease (Phase 4) Martek Biosciences Corporation, NeuroBioPharm, Inc. Other Dietary Supplement
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
Epigallocatechin Gallate (EGCG) Sunphenon EGCg Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) Taiyo International Amyloid-Related, Inflammation, Other Dietary Supplement
Estrogen Premarin™ Alzheimer's Disease (Discontinued) Other Other Hormone Replacement Therapy
Exendin-4 Exenatide,
Byetta,
Bydureon
Alzheimer's Disease (Phase 2) Other Small Molecule Diabetes mellitus in US
FRM-0334 EVP-0334 Frontotemporal Dementia (Phase 2) FORUM Pharmaceuticals Inc. Other Small Molecule
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
Idebenone Catena,
Sovrima
Alzheimer's Disease (Discontinued) Takeda Pharmaceutical Company Other Small Molecule None
Ketasyn Axona,
Caprylic Acid,
AC-1202
Alzheimer's Disease (Phase 4) Accera, Inc. Other Dietary Supplement
Leuprolide Leuprolide acetate Alzheimer's Disease (Discontinued) Other Other None
Linopirdine DuP996 Alzheimer's Disease (Discontinued) Other Small Molecule None
Liraglutide Victoza™ Alzheimer's Disease (Phase 2) Novo Nordisk A/S Other Small Molecule
MEM 1003 BAY Z 4406 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) Memory Pharmaceuticals Corporation Other Small Molecule None
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) AB Science Other Small Molecule
Melatonin Alzheimer's Disease (Phase 2) Other Dietary Supplement None
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Dietary Supplement
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
Nicotinamide Enduramide,
Niacinamide,
Nicotinic acid amide,
Vitamin B3
Alzheimer's Disease (Phase 2) Other Small Molecule
Nilvadipine Nilvad,
Nivadil,
ARC029
Alzheimer's Disease (Phase 3) Archer Pharmaceuticals, Inc. Other Small Molecule
PRX-03140 Potassium salt Alzheimer's Disease (Inactive) Epix Pharmaceuticals Other Small Molecule
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
Mild Cognitive Impairment (Phase 3) Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Type 2 diabetes mellitus
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Repetitive Transcranial Magnetic Stimulation rTMS Alzheimer's Disease (Phase 2) Neuronix Ltd Other Procedural Intervention
Resveratrol trans-3,4',5-trihydroxystilbene Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) Other Small Molecule, Dietary Supplement
Rilapladib SB-659032 Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rosiglitazone Rosiglitazone maleate,
Avandia
Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Other Small Molecule
S-Equol Aus-131 Alzheimer's Disease (Phase 1) Ausio Pharmaceuticals, LLC Other Small Molecule
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
Saracatinib AZD0530 Alzheimer's Disease (Phase 2) AstraZeneca Other Small Molecule
Sargramostim Leukine®,
GM-CSF
Alzheimer's Disease (Phase 2) Genzyme, Sanofi Inflammation, Other, Unknown Other Bone Marrow Stimulation
Sembragiline RO4602522,
RG1577
Alzheimer's Disease (Discontinued) Evotech AG, Roche Other Neurotransmitters, Other Small Molecule
Souvenaid FortasynTM Connect Alzheimer's Disease (Not Regulated) Other Dietary Supplement
T-817MA T 817MA, T817MA Alzheimer's Disease (Phase 2) Toyama Chemical Co., Ltd. Other, Unknown Small Molecule
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
Xaliproden SR 57746A Alzheimer's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule
XanamemTM UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule
Young Plasma Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 1) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other