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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
ABT 418 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
ABT-089 Discontinued Abbott Laboratories Cholinergic System Small Molecule Alzheimer's Disease
ABT-288 Discontinued AbbVie Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
ABT-384 Discontinued AbbVie Other Small Molecule Alzheimer's Disease
AF 102B cevimeline HCL,
Evoxac™
Discontinued SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Alzheimer's Disease Treatment of dry mouth in Sjogren's syndrome.
AZD1446 TC-6683 Discontinued AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease None
Atomoxetine ATX,
Strattera
Discontinued Eli Lilly & Co. Other Neurotransmitters Small Molecule Alzheimer's Disease ADHD in US
Avagacestat BMS-708163 Discontinued Bristol-Myers Squibb Amyloid-Related Small Molecule Alzheimer's Disease
BI 1181181 VTP 37948,
BACE inhibitor
Discontinued Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule Alzheimer's Disease
Besipirdine HCl HP 749 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
CX516 Ampalex Discontinued Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease None
Celecoxib Celebrex Discontinued Pfizer Inflammation Small Molecule Alzheimer's Disease Pain, Arthritis
Clioquinol iodochlorhydroxyquin,
PBT-1
Discontinued Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule Alzheimer's Disease
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Discontinued, Discontinued Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Alzheimer's Disease, Huntington's Disease Anti-histamine use in Russia
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
Discontinued, Discontinued FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma Cholinergic System Small Molecule Alzheimer's Disease, Schizophrenia None
Epothilone D BMS-241027 Discontinued Bristol-Myers Squibb Tau Small Molecule Alzheimer's Disease
Eptastigmine MF 201 Discontinued Mediolanum Cholinergic System Small Molecule Alzheimer's Disease None
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Discontinued Myriad Genetics & Laboratories Amyloid-Related Small Molecule Alzheimer's Disease None
GSK239512 Discontinued GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
HF0220 Discontinued Newron Inflammation Small Molecule Alzheimer's Disease
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Discontinued Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease Pain and Fever
Idebenone Catena,
Sovrima
Discontinued Takeda Pharmaceutical Company Other Small Molecule Alzheimer's Disease None
LU25-109 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
LY2886721 BACE inhibitor Discontinued, Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
Linopirdine DuP996 Discontinued Other Small Molecule Alzheimer's Disease None
Lornoxicam Discontinued, Discontinued JSW Lifesciences Inflammation Small Molecule Alzheimer's Disease, Mild Cognitive Impairment Pain in US
MEM 1003 BAY Z 4406 Discontinued, Discontinued, Discontinued, Discontinued Memory Pharmaceuticals Corporation Other Small Molecule Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, Bipolar Disorder None
Metrifonate trichlorfon Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
Milameline CI 979 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule Alzheimer's Disease None
NS2330 Tesofensine Discontinued NeuroSearch A/S Other Neurotransmitters Small Molecule Alzheimer's Disease
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Discontinued Procter & Gamble, Roche Inflammation Small Molecule Alzheimer's Disease Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness.
Nefiracetam Discontinued Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule Alzheimer's Disease None
NeoTrofin AIT-082,
leteprinim
Discontinued NeoTherapeutics, Inc. Unknown Small Molecule Alzheimer's Disease None
Neramexane MRZ 2/579 Discontinued Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule Alzheimer's Disease None
Physostigmine Salicylate Synapton Discontinued Forest Laboratories, Inc. Cholinergic System Small Molecule Alzheimer's Disease
Prednisone Discontinued Inflammation Small Molecule Alzheimer's Disease
Propentofylline HWA 285,
PPF
Discontinued Unknown Small Molecule Alzheimer's Disease
RG7129 RO5508887,
BACE Inhibitor
Discontinued Roche Amyloid-Related Small Molecule Alzheimer's Disease
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Discontinued TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Rofecoxib Vioxx™ Discontinued Merck Inflammation Small Molecule Alzheimer's Disease Withdrawn from market
Rosiglitazone Rosiglitazone maleate,
Avandia
Discontinued GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
S 38093 Discontinued Servier Cholinergic System, Other Neurotransmitters Small Molecule Alzheimer's Disease
SB 202026 Memric Discontinued Other Neurotransmitters Small Molecule Alzheimer's Disease
SGS-742 CGP-36742,
DVD-742
Discontinued Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease None
Sembragiline RO4602522,
RG1577
Discontinued Evotech AG, Roche Other Neurotransmitters, Other Small Molecule Alzheimer's Disease
Suritozole MD 26479 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Discontinued, Discontinued Zeltia Group Tau Small Molecule Alzheimer's Disease, Progressive Supranuclear Palsy
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Discontinued Pfizer Cholinergic System Small Molecule Alzheimer's Disease Smoking cessation
Xaliproden SR 57746A Discontinued Sanofi Other Neurotransmitters, Other Small Molecule Alzheimer's Disease