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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
Brexpiprazole OPC 34712 3 H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
3, 3 FORUM Pharmaceuticals Inc. (was EnVivo Pharmaceuticals), Mitsubishi Tanabe Pharma Cholinergic System Small Molecule Alzheimer's Disease, Schizophrenia None
Idalopirdine Lu AE58054,
SGS 518
3, Inactive Eli Lilly & Co., H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
3, 3 AB Science Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
MK-8931 MK-8931-009 ,
BACE inhibitor
3 Merck Amyloid-Related Small Molecule Alzheimer's Disease
Nilvadipine Nilvad,
Nivadil,
ARC029
3 Archer Pharmaceuticals, Inc. Other Small Molecule Alzheimer's Disease
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
3 Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Mild Cognitive Impairment Type 2 diabetes mellitus
TRx0237 LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
3, 3 TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease, Frontotemporal Dementia Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.