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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
ABT 418 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
ABT-089 Alzheimer's Disease (Discontinued) Abbott Laboratories Cholinergic System Small Molecule
ABT-288 Alzheimer's Disease (Discontinued) AbbVie Cholinergic System, Other Neurotransmitters Small Molecule
ABT-384 Alzheimer's Disease (Discontinued) AbbVie Other Small Molecule
AF 102B cevimeline HCL,
Evoxac™
Alzheimer's Disease (Discontinued) SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Treatment of dry mouth in Sjogren's syndrome.
AZD1446 TC-6683 Alzheimer's Disease (Discontinued) AstraZeneca, Targacept Cholinergic System Small Molecule None
Atomoxetine ATX,
Strattera
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Other Neurotransmitters Small Molecule ADHD in US
Avagacestat BMS-708163 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Amyloid-Related Small Molecule
BI 1181181 VTP 37948,
BACE inhibitor
Alzheimer's Disease (Discontinued) Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule
Besipirdine HCl HP 749 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
CX516 Ampalex Alzheimer's Disease (Discontinued) Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule None
Celecoxib Celebrex Alzheimer's Disease (Discontinued) Pfizer Inflammation Small Molecule Pain, Arthritis
Clioquinol iodochlorhydroxyquin,
PBT-1
Alzheimer's Disease (Discontinued) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
Dimebon Dimebolin,
Latrepirdine,
Pf-01913539
Alzheimer's Disease (Discontinued), Huntington's Disease (Discontinued) Medivation, Inc. Other Neurotransmitters, Unknown Small Molecule Anti-histamine use in Russia
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma Cholinergic System Small Molecule None
Epothilone D BMS-241027 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Tau Small Molecule
Eptastigmine MF 201 Alzheimer's Disease (Discontinued) Mediolanum Cholinergic System Small Molecule None
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Alzheimer's Disease (Discontinued) Myriad Genetics & Laboratories Amyloid-Related Small Molecule None
GSK239512 Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule
HF0220 Alzheimer's Disease (Discontinued) Newron Inflammation Small Molecule
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Alzheimer's Disease (Discontinued) Amyloid-Related, Inflammation Small Molecule Pain and Fever
Idebenone Catena,
Sovrima
Alzheimer's Disease (Discontinued) Takeda Pharmaceutical Company Other Small Molecule None
LU25-109 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
LY2886721 BACE inhibitor Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
Ladostigil Ladostigil hemitartrate,
TV3326
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) Avraham Pharmaceuticals Ltd Cholinergic System Small Molecule
Linopirdine DuP996 Alzheimer's Disease (Discontinued) Other Small Molecule None
Lornoxicam Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) JSW Lifesciences Inflammation Small Molecule Pain in US
MEM 1003 BAY Z 4406 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) Memory Pharmaceuticals Corporation Other Small Molecule None
MK-7622 Alzheimer's Disease (Discontinued) Merck Unknown Small Molecule
Metrifonate trichlorfon Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
Milameline CI 979 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule None
NS2330 Tesofensine Alzheimer's Disease (Discontinued) NeuroSearch A/S Other Neurotransmitters Small Molecule
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Alzheimer's Disease (Discontinued) Procter & Gamble Inflammation Small Molecule Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness.
Nefiracetam Alzheimer's Disease (Discontinued) Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule None
Nelonicline ABT-126 Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) AbbVie Cholinergic System Small Molecule
NeoTrofin AIT-082,
leteprinim
Alzheimer's Disease (Discontinued) NeoTherapeutics, Inc. Unknown Small Molecule None
Neramexane MRZ 2/579 Alzheimer's Disease (Discontinued) Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule None
Physostigmine Salicylate Synapton Alzheimer's Disease (Discontinued) Forest Laboratories, Inc. Cholinergic System Small Molecule
Prednisone Alzheimer's Disease (Discontinued) Inflammation Small Molecule
Propentofylline HWA 285,
PPF
Alzheimer's Disease (Discontinued) Unknown Small Molecule
RG7129 RO5508887,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Roche Amyloid-Related Small Molecule
Rember TM Methylene Blue ,
methylthioninium (MT),
TRx-0014,
Tau aggregation inhibitor (TAI)
Alzheimer's Disease (Discontinued) TauRx Therapeutics Ltd Tau Small Molecule Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Rofecoxib Vioxx™ Alzheimer's Disease (Discontinued) Merck Inflammation Small Molecule Withdrawn from market
Rosiglitazone Rosiglitazone maleate,
Avandia
Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Other Small Molecule
S 38093 Alzheimer's Disease (Discontinued) Servier Cholinergic System, Other Neurotransmitters Small Molecule
SB 202026 Memric Alzheimer's Disease (Discontinued) Other Neurotransmitters Small Molecule
SGS-742 CGP-36742,
DVD-742
Alzheimer's Disease (Discontinued) Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule None
Sembragiline RO4602522,
RG1577
Alzheimer's Disease (Discontinued) Evotech AG, Roche Other Neurotransmitters, Other Small Molecule
Suritozole MD 26479 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Alzheimer's Disease (Discontinued), Progressive Supranuclear Palsy (Discontinued) Zeltia Group Tau Small Molecule
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Alzheimer's Disease (Discontinued) Pfizer Cholinergic System Small Molecule Smoking cessation
Xaliproden SR 57746A Alzheimer's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule