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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
ABT 418 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
ABT-089 Alzheimer's Disease (Discontinued) Abbott Laboratories Cholinergic System Small Molecule
ABT-288 Alzheimer's Disease (Discontinued) AbbVie Cholinergic System, Other Neurotransmitters Small Molecule
AF 102B cevimeline HCL,
Evoxac™
Alzheimer's Disease (Discontinued) SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Treatment of dry mouth in Sjogren's syndrome.
AZD1446 TC-6683 Alzheimer's Disease (Discontinued) AstraZeneca, Targacept Cholinergic System Small Molecule None
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
Alzheimer's Disease (Discontinued), Schizophrenia (Discontinued) FORUM Pharmaceuticals Inc., Mitsubishi Tanabe Pharma Cholinergic System Small Molecule None
Eptastigmine MF 201 Alzheimer's Disease (Discontinued) Mediolanum Cholinergic System Small Molecule None
GSK239512 Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Cholinergic System, Other Neurotransmitters Small Molecule
LU25-109 Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
Ladostigil Ladostigil hemitartrate,
TV3326
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Discontinued) Avraham Pharmaceuticals Ltd Cholinergic System Small Molecule
Metrifonate trichlorfon Alzheimer's Disease (Discontinued) Cholinergic System Small Molecule None
Milameline CI 979 Alzheimer's Disease (Discontinued) Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule None
Nefiracetam Alzheimer's Disease (Discontinued) Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule None
Nelonicline ABT-126 Alzheimer's Disease (Discontinued), Schizophrenia (Inactive) AbbVie Cholinergic System Small Molecule
Physostigmine Salicylate Synapton Alzheimer's Disease (Discontinued) Forest Laboratories, Inc. Cholinergic System Small Molecule
S 38093 Alzheimer's Disease (Discontinued) Servier Cholinergic System, Other Neurotransmitters Small Molecule
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Alzheimer's Disease (Discontinued) Pfizer Cholinergic System Small Molecule Smoking cessation