Therapeutics
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| Name | Synonyms | FDA Status | Company | Target Type | Therapy Type | Condition | Approved For |
|---|---|---|---|---|---|---|---|
| LMTM | TRx0237, LMT-X, Methylene Blue, Tau aggregation inhibitor (TAI) |
3, 3 | TauRx Therapeutics Ltd | Tau | Small Molecule | Alzheimer's Disease, Frontotemporal Dementia | Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia. |
| AGB101 | Levetiracetam, Keppra |
3, Discontinued | AgeneBio, Inc. | Amyloid-Related, Other | Small Molecule | Mild Cognitive Impairment, Parkinson's Disease | Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries |
| ALZT-OP1 | Cromolyn sodium, Intal, Ibuprofen |
3 | AZTherapies, Inc. | Amyloid-Related, Inflammation | Small Molecule | Alzheimer's Disease | |
| AVP-786 | 3, 2 | Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | Alzheimer's Disease, Schizophrenia | ||
| AZD3293 | LY3314814, BACE inhibitor |
3 | AstraZeneca, Eli Lilly & Co. | Amyloid-Related | Small Molecule | Alzheimer's Disease | |
| Aripiprazole | Abilify, BMS-337039 |
3, Approved | Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | Alzheimer's Disease, Schizophrenia | |
| Azeliragon | PF-04494700 , TTP488 |
3 | Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC | Amyloid-Related, Inflammation | Small Molecule | Alzheimer's Disease | |
| Brexpiprazole | Rexulti, OPC 34712 |
3, Approved | H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | Alzheimer's Disease, Schizophrenia | |
| Elenbecestat | E2609, BACE inhibitor |
3 | Biogen, Eisai Co., Ltd. | Amyloid-Related | Small Molecule | Alzheimer's Disease | |
| ITI-007 | 3, 3, 3 | Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. | Other Neurotransmitters | Small Molecule | Alzheimer's Disease, Schizophrenia, Bipolar Disorder | ||
| Idalopirdine | Lu AE58054, SGS 518 |
3, Inactive | H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. | Other Neurotransmitters | Small Molecule | Alzheimer's Disease, Schizophrenia | |
| Intepirdine | RVT-101, SB 742457 , GSK 742457 |
3, 2/3 | Axovant Sciences Ltd. | Other Neurotransmitters | Small Molecule | Alzheimer's Disease, Dementia with Lewy Bodies | |
| Masitinib | Masivet, Kinavet, AB1010, Masitinib mesylate |
3, 3 | AB Science | Other | Small Molecule | Alzheimer's Disease, Amyotrophic Lateral Sclerosis | |
| Nilvadipine | Nilvad, Nivadil, ARC029 |
3 | Archer Pharmaceuticals, Inc. | Other | Small Molecule | Alzheimer's Disease | |
| Pioglitazone | AD4833, Actos®, Glustin™, Piozone® |
3 | Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. | Inflammation, Other | Small Molecule | Mild Cognitive Impairment | Type 2 diabetes mellitus |
| Verubecestat | MK-8931, MK-8931-009 , BACE inhibitor |
3 | Merck | Amyloid-Related | Small Molecule | Alzheimer's Disease |