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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
LMTM TRx0237, LMT-X,
Methylene Blue,
Tau aggregation inhibitor (TAI)
3, 3 TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease, Frontotemporal Dementia Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
AGB101 Levetiracetam,
Keppra
3, Discontinued AgeneBio, Inc. Amyloid-Related, Other Small Molecule Mild Cognitive Impairment, Parkinson's Disease Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
3 AZTherapies, Inc. Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
AVP-786 3, 2 Avanir Pharmaceuticals, Concert Pharmaceuticals, Inc., Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
AZD3293 LY3314814,
BACE inhibitor
3 AstraZeneca, Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease
Aducanumab BIIB037 3 Biogen Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
Alpha-Tocopherol Vitamin E 3 Other Dietary Supplement Alzheimer's Disease
Aripiprazole Abilify,
BMS-337039
3, Approved Bristol-Myers Squibb, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Azeliragon PF-04494700 ,
TTP488
3 Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
Brexpiprazole Rexulti,
OPC 34712
3, Approved H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Continuous Positive Airway Pressure CPAP 3 Unknown Procedural Intervention Alzheimer's Disease Sleep Apnea in US
Crenezumab MABT5102A ,
RG7412
3 AC Immune SA, Genentech, Hoffmann-La Roche Amyloid-Related Immunotherapy (passive) Alzheimer's Disease None
Elenbecestat E2609,
BACE inhibitor
3 Biogen, Eisai Co., Ltd. Amyloid-Related Small Molecule Alzheimer's Disease
Gantenerumab RO4909832,
RG1450
3 Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche Amyloid-Related Immunotherapy (passive) Alzheimer's Disease
ITI-007 3, 3, 3 Bristol-Myers Squibb, Intra-Cellular Therapies, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia, Bipolar Disorder
Idalopirdine Lu AE58054,
SGS 518
3, Inactive H. Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Intepirdine RVT-101,
SB 742457 ,
GSK 742457
3, 2/3 Axovant Sciences Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Dementia with Lewy Bodies
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
3, 3 AB Science Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Nilvadipine Nilvad,
Nivadil,
ARC029
3 Archer Pharmaceuticals, Inc. Other Small Molecule Alzheimer's Disease
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
3 Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Mild Cognitive Impairment Type 2 diabetes mellitus
Solanezumab LY2062430 3 Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) Alzheimer's Disease None
Verubecestat MK-8931, MK-8931-009 ,
BACE inhibitor
3 Merck Amyloid-Related Small Molecule Alzheimer's Disease