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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AAB-003 PF-05236812 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
ABBV-0805 BAN0805 Parkinson's Disease (Inactive) AbbVie, BioArctic AB alpha-synuclein Immunotherapy (passive)
ABBV-916 N3pG-Abeta mAb Alzheimer's Disease (Phase 2) Amyloid-Related Immunotherapy (passive)
ACU193 ACU-193 Alzheimer's Disease (Phase 1) Acumen Pharmaceuticals, Inc. Amyloid-Related Immunotherapy (passive)
Aduhelm Aducanumab,
BIIB037
Alzheimer's Disease (Approved) Biogen, Neurimmune Amyloid-Related Immunotherapy (passive)
AL002 Alzheimer's Disease (Phase 2) AbbVie, Alector Inflammation Immunotherapy (passive)
AL003 Alzheimer's Disease (Discontinued) AbbVie, Alector Inflammation Immunotherapy (passive)
AL044 Alzheimer's Disease (Phase 1) Alector Inflammation Immunotherapy (passive)
AL101 GSK-4527226 Alzheimer's Disease (Phase 1) Alector Other Immunotherapy (passive)
ANX005 Amyotrophic Lateral Sclerosis (Phase 2) Annexon, Inc. Inflammation, Other Immunotherapy (passive)
APNmAb005 RAA7 Alzheimer's Disease (Phase 1) Aprinoia Therapeutics Tau Immunotherapy (passive)
Bapineuzumab AAB-001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
Bepranemab UCB0107 ,
UCB 0107 ,
Antibody D
Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 2) Hoffmann-La Roche, UCB S.A. Tau Immunotherapy (passive)
BIIB076 NI-105,
6C5 huIgG1/l
Alzheimer's Disease (Discontinued) Biogen, Eisai Co., Ltd., Neurimmune Tau Immunotherapy (passive)
BMS-986446 PRX005 Alzheimer's Disease (Phase 1) Bristol-Myers Squibb, Prothena Tau Immunotherapy (passive)
Cinpanemab BIIB054,
NI-202
Parkinson's Disease (Discontinued) Biogen, Neurimmune alpha-synuclein Immunotherapy (passive)
Crenezumab MABT5102A ,
RG7412
Alzheimer's Disease (Discontinued) AC Immune SA, Genentech, Hoffmann-La Roche Amyloid-Related Immunotherapy (passive) None
DNL919 TAK-920,
ATV:TREM2
Alzheimer's Disease (Discontinued) Denali Therapeutics Inc., Takeda Pharmaceutical Company Amyloid-Related, Inflammation Immunotherapy (passive)
Donanemab N3pG-Aβ Monoclonal Antibody,
LY3002813
Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
E2814 Alzheimer's Disease (Phase 1/2) Eisai Co., Ltd. Tau Immunotherapy (passive)
Etanercept Enbrel™ Alzheimer's Disease (Phase 2) Amgen, Inc., Pfizer Inflammation Immunotherapy (passive) Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis
Gammagard® Intravenous Immunoglobulin,
IVIg
Alzheimer's Disease (Discontinued) Baxter Healthcare Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency conditions
Gamunex Intravenous Immunoglobulin,
Human Albumin Combined With Flebogamma
Alzheimer's Disease (Phase 2/3) Grifols Biologicals Inc. Amyloid-Related, Inflammation Combination, Immunotherapy (passive) Immunodeficiency, chronic inflammatory demyelinating neuropathy
Gantenerumab RO4909832,
RG1450,
R1450
Alzheimer's Disease (Discontinued) Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
Gosuranemab BIIB092,
BMS-986168, IPN007
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) Biogen, Bristol-Myers Squibb Tau Immunotherapy (passive)
GSK933776 Alzheimer's Disease (Inactive) GlaxoSmithKline (GSK) Amyloid-Related Immunotherapy (passive)
IBC-Ab002 Alzheimer's Disease (Phase 1) ImmunoBrain Checkpoint Amyloid-Related, Inflammation, Other Immunotherapy (passive)
JNJ-63733657 Mild AD (Phase 2) Janssen Tau Immunotherapy (passive)
Latozinemab AL001,
GSK4527223
Frontotemporal Dementia (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2) Alector, GlaxoSmithKline (GSK) Other Immunotherapy (passive)
Leqembi Lecanemab-irmb,
BAN2401,
mAb158
Alzheimer's Disease (Approved) BioArctic AB, Biogen, Eisai Co., Ltd. Amyloid-Related Immunotherapy (passive)
LU AF82422 Parkinson's Disease (Phase 1), Multiple System Atrophy (Phase 2) Genmab A/S, Lundbeck alpha-synuclein Immunotherapy (passive)
Lu AF87908 hC10.2 Alzheimer's Disease (Phase 1) Lundbeck Tau Immunotherapy (passive)
LY2599666 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
MEDI1814 Alzheimer's Disease (Phase 1) AstraZeneca, Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
MK-2214 Alzheimer's Disease (Phase 1) Merck Tau Immunotherapy (passive)
Octagam®10% Intravenous Immunoglobulin,
NewGam
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) Octapharma Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency disorders
Pepinemab VX15,
VX15/2503
Alzheimer's Disease (Phase 1/2), Huntington's Disease (Phase 2) Vaccinex, Inc. Inflammation Immunotherapy (passive)
PNT001 Alzheimer's Disease (Phase 1), Traumatic Brain Injury (Phase 1) Pinteon Therapeutics Tau Immunotherapy (passive)
Ponezumab PF-04360365 Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) Pfizer Amyloid-Related Immunotherapy (passive) None
Prasinezumab PRX002, RO7046015, RG7935, NEOD002 Parkinson's Disease (Phase 2) Hoffmann-La Roche, Prothena alpha-synuclein Immunotherapy (passive)
PRX012 Alzheimer's Disease (Phase 1) Prothena Amyloid-Related Immunotherapy (passive)
Remternetug LY3372993,
N3pG-Abeta mAb
Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
RG7345 RO6926496 Alzheimer's Disease (Discontinued) Tau Immunotherapy (passive)
SAR228810 Alzheimer's Disease (Discontinued) Sanofi Amyloid-Related Immunotherapy (passive)
Semorinemab RO7105705 ,
MTAU9937A,
RG6100
Alzheimer's Disease (Phase 2) AC Immune SA, Genentech, Hoffmann-La Roche Tau Immunotherapy (passive)
Solanezumab LY2062430 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) None
TAK-341 MEDI1341 Parkinson's Disease (Phase 1), Multiple System Atrophy (Phase 2) AstraZeneca, Takeda Pharmaceutical Company alpha-synuclein Immunotherapy (passive)
TB006 Alzheimer's Disease (Phase 1) TrueBinding, Inc. Inflammation Immunotherapy (passive)
Tilavonemab ABBV-8E12,
C2N 8E12,
HJ8.5
Progressive Supranuclear Palsy (Discontinued), Alzheimer's Disease (Discontinued) AbbVie, C2N Diagnostics, LLC Tau Immunotherapy (passive)
Trontinemab RO7126209,
RG6102 ,
Brain shuttle gantenerumab
Alzheimer's Disease (Phase 1) Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
UCB7853 Parkinson's Disease (Phase 1) UCB S.A. alpha-synuclein Immunotherapy (passive)
VGL101 Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (Phase 1) Vigil Neuroscience, Inc. Inflammation, Other Immunotherapy (passive)
Zagotenemab LY3303560 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Tau, Unknown Immunotherapy (passive)