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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AAV2-BDNF MCI due to AD (Phase 1), Alzheimer's Disease (Phase 1) Other DNA/RNA-based
ABBV-552 Alzheimer's Disease (Phase 1) AbbVie Other Small Molecule
ABBV-CLS-7262 Amyotrophic Lateral Sclerosis (Phase 1) Other Small Molecule
ABT-384 Alzheimer's Disease (Discontinued) AbbVie Other Small Molecule
ABT-957 Alicapistat Alzheimer's Disease (Discontinued) AbbVie Other Small Molecule
ACD856 Alzheimer's Disease (Phase 1) AlzeCure Pharma AB Other Small Molecule
Acetyl-l-carnitine HCI ALCAR Alzheimer's Disease (Discontinued) Sigma-Tau Pharmaceuticals Other Supplement, Dietary
AL101 GSK-4527226 Alzheimer's Disease (Phase 1) Alector Other Immunotherapy (passive)
Allopregnanolone brexanolone,
3α-hydroxy-5α-pregnan-20-one,
3α,5α-tetrahydroprogesterone
Alzheimer's Disease (Phase 2) Other Neurotransmitters, Other Small Molecule
Alpha-Tocopherol Vitamin E Alzheimer's Disease (Phase 3) Other Supplement, Dietary
Ambroxol Ambrosan, Mucosolvan Parkinson's Disease (Phase 2), Parkinson's Disease Dementia (Phase 2), Dementia with Lewy Bodies (Phase 2) alpha-synuclein, Other Small Molecule
ANX005 Amyotrophic Lateral Sclerosis (Phase 2) Annexon, Inc. Inflammation, Other Immunotherapy (passive)
Apabetalone RVX208,
RVX000222
MCI-VaD (Phase 3) Resverlogix Corporation Other Small Molecule
AR1001 Alzheimer's Disease (Phase 3) Aribio Co., Ltd. Other Small Molecule
Atuzaginstat COR388 Alzheimer's Disease (Discontinued) Cortexyme, Inc., Quince Therapeutics Other Small Molecule
Benfotiamine S-benzoylthiamine-O-monophosphate,
Vitamin B1,
Thiamine
Alzheimer's Disease (Phase 2) Inflammation, Other Supplement, Dietary
BI 409306 SUB 166499 Alzheimer's Disease (Discontinued), Schizophrenia (Phase 2) Boehringer Ingelheim Other Neurotransmitters, Other Small Molecule
Bifidobacterium breve A1 MCC1274,
B. breve
Mild Cognitive Impairment (Phase 2) Morinaga Milk Industry Co., Ltd Other Supplement, Dietary
BIIB078 BIIB-078,
IONIS-C9Rx
Amyotrophic Lateral Sclerosis (Discontinued) Biogen, IONIS Pharmaceuticals Other DNA/RNA-based
BIIB094 ION859,
IONIS-BIIB7Rx
Parkinson's Disease (Phase 1) Biogen, IONIS Pharmaceuticals Inflammation, Other DNA/RNA-based
BIIB100 KPT-350 Amyotrophic Lateral Sclerosis (Discontinued) Biogen Inflammation, Other Small Molecule
BIIB105 ION541 Amyotrophic Lateral Sclerosis (Phase 1/2) Biogen, IONIS Pharmaceuticals Other DNA/RNA-based
BIIB118 PF-05251749 Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) Biogen Other Small Molecule
Blarcamesine Anavex 2-73 Alzheimer's Disease (Phase 2/3), Parkinson's Disease Dementia (Phase 2), Parkinson's Disease (Phase 1) Anavex Life Science Corp. Other Small Molecule
Bosutinib BOSULIF®,
PF-5208763,
SKI-606
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) Pfizer Other Small Molecule Chronic myeloid leukemia
BPN14770 Alzheimer's Disease (Phase 2) Shionogi Pharma, Tetra Therapeutics Cholinergic System, Other Small Molecule
BRT-DA01 Bemdaneprocel ,
MSK-DA01
Parkinson's Disease (Phase 1) Bayer, BlueRock Therapeutics Other Neurotransmitters, Other Other
Bryostatin 1 Alzheimer's Disease (Phase 2) Synaptogenix, Inc. Other Other
Candesartan Atacand,
Candesartan cilexetil
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) AstraZeneca, Takeda Pharmaceutical Company Other Small Molecule Hypertension, congestive heart failure
CDNF cerebral dopamine neurotrophic factor Parkinson's Disease (Phase 1/2) Herantis Pharma Plc, Renishaw plc. Other Procedural Intervention, Other
CERE-110 Nerve Growth Factor gene therapy Alzheimer's Disease (Discontinued) Sangamo BioSciences, Inc. Other DNA/RNA-based
Cerebrolysin Alzheimer's Disease (Phase 2) Ebewe Pharmaceutical Other Other
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
CNM-Au8 Gold nanocrystals Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2/3) Clene Nanomedicine, Inc. Metals, Other Other
Cocoa Flavanols Mild Cognitive Impairment (Not Regulated) Inflammation, Other Supplement, Dietary
COGNIShunt™ Alzheimer's Disease (Inactive) Other Procedural Intervention None
Curcumin diferuloylmethane,
Longvida™
Alzheimer's Disease (Phase 2) Verdure Sciences Other, Unknown Supplement, Dietary None
Dapagliflozin Farxiga,
Forxiga,
BMS 512148
Alzheimer's Disease (Phase 1/2) AstraZeneca, Bristol-Myers Squibb Other Small Molecule
Dapsone Avlosulfon,
Diaminodiphenylsulfone,
DDS
Alzheimer's Disease (Inactive) Immune Network Ltd. Other Small Molecule Leprosy, malaria, some bacterial skin infections
Dasatinib + Quercetin Alzheimer's Disease (Phase 1/2) Tau, Other Combination, Small Molecule, Supplement, Dietary
Dayvigo Lemborexant,
E2006
Alzheimer's Disease (Phase 2) Eisai Co., Ltd. Other Small Molecule Insomnia
Deep Brain Stimulation-nucleus basalis of Meynert DBS-nbM Alzheimer's Disease (Phase 2) Cholinergic System, Other Procedural Intervention
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
DNL151 BIIB122 Parkinson's Disease (Phase 2) Biogen, Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL201 Parkinson's Disease (Inactive) Biogen, Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL343 Amyotrophic Lateral Sclerosis (Phase 2/3) Denali Therapeutics Inc. Other Small Molecule
DNL593 PTV:PGRN,
TAK-594
Frontotemporal Dementia (Phase 1/2) Denali Therapeutics Inc., Takeda Pharmaceutical Company Other Other
Docosahexaenoic acid (DHA) Omega-3 fatty acid Alzheimer's Disease (Phase 4) Martek Biosciences Corporation, NeuroBioPharm, Inc. Other Supplement, Dietary
Edaravone MCI-186,
Radicava®,
Radicut®,
MT-1186,
FAB122
Amyotrophic Lateral Sclerosis (Phase 4) Mitsubishi Tanabe Pharma Other Small Molecule Amyotrophic Lateral Sclerosis
Edonerpic T-817 MA, T 817 Alzheimer's Disease (Discontinued) Toyama Chemical Co., Ltd. Other, Unknown Small Molecule
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
Empagliflozin Jardiance,
BI-10773
Alzheimer's Disease (Phase 1) Boehringer Ingelheim, Eli Lilly & Co. Other Small Molecule Type 2 Diabetes, Cardiovascular disease
Emrusolmin Anle138b,
TEV-56286
Parkinson's Disease (Phase 1/2) MODAG GmbH, Teva Tau, alpha-synuclein, Other Small Molecule
Emtricitabine Alzheimer's Disease (Phase 1) Gilead Sciences, Inc. Other Small Molecule
Engensis VM202, pCK-HGF-X7, NL003, hepatocyte growth factor Amyotrophic Lateral Sclerosis (Phase 2) Helixmith Other DNA/RNA-based
Epigallocatechin Gallate (EGCG) Sunphenon EGCg Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) Taiyo International Amyloid-Related, Inflammation, Other Supplement, Dietary
Estrogen Premarin™ Alzheimer's Disease (Discontinued) Other Other Hormone Replacement Therapy
Exenatide Exendin-4,
Byetta,
Bydureon
Alzheimer's Disease (Inactive), Parkinson's Disease (Phase 3) Other Small Molecule Diabetes mellitus in US
Ezeprogind AZP2006 ,
AZP-2006
Progressive Supranuclear Palsy (Phase 2) AlzProtect Tau, Inflammation, Other Small Molecule
Focused Ultrasound – Blood-Brain Barrier FUS-BBB,
MRgFUS,
MRI-Guided Focused Ultrasound,
FUS+MB
Alzheimer's Disease (Phase 1), Amyotrophic Lateral Sclerosis (Phase 1), Mild Cognitive Impairment (Phase 1), Parkinson's Disease (Phase 1) Amyloid-Related, Other Procedural Intervention
Fosgonimeton ATH-1017,
NDX-1017
Alzheimer's Disease (Phase 2/3), Dementia with Lewy Bodies (Phase 2), Parkinson's Disease Dementia (Phase 2) Athira Pharma Other Small Molecule
FRM-0334 EVP-0334 Frontotemporal Dementia (Discontinued) FORUM Pharmaceuticals Inc. Other Small Molecule
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
GRF6019 Alzheimer's Disease (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
GRF6021 AKST/GRF6021 Parkinson's Disease Dementia (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
GV1001 RIAVAXTM, Tertomotide Alzheimer's Disease (Phase 3) GemVax & KAEL Bio Other Immunotherapy (active) Pancreatic cancer (Korea)
IBC-Ab002 Alzheimer's Disease (Phase 1) ImmunoBrain Checkpoint Amyloid-Related, Inflammation, Other Immunotherapy (passive)
Idebenone Catena,
Sovrima
Alzheimer's Disease (Discontinued) Takeda Pharmaceutical Company Other Small Molecule None
Intranasal oxytocin Syntocinon,
Pitocin
Frontotemporal Dementia (Phase 2) Other Other
Irsenontrine E2027 Dementia with Lewy Bodies (Phase 2) Eisai Co., Ltd. Other Small Molecule
Ketasyn Axona,
Caprylic Acid,
AC-1202
Alzheimer's Disease (Phase 4) Cerecin Pte. Ltd. Other Supplement, Dietary
kMCT-ONS medium chain triglyceride-based ketogenic oral nutritional supplement, kMCT Alzheimer's Disease (Not Regulated) Nestlé Health Science Other Supplement, Dietary
Latozinemab AL001,
GSK4527223
Frontotemporal Dementia (Phase 3), Amyotrophic Lateral Sclerosis (Phase 2) Alector, GlaxoSmithKline (GSK) Other Immunotherapy (passive)
Leuprolide Leuprolide acetate ,
Lupron Depot,
Eligard
Alzheimer's Disease (Phase 2) Tolmar Pharmaceuticals, Inc. Other Other Advanced prostate cancer
Levetiracetam Keppra Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) UCB S.A. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Linopirdine DuP996 Alzheimer's Disease (Discontinued) Other Small Molecule None
Liraglutide Victoza™,
Saxenda™
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2) Novo Nordisk A/S Other Other Diabetes, weight loss
LM11A-31-BHS LM11A-31 Alzheimer's Disease (Phase 2) PharmatrophiX Other Small Molecule
Lomecel-B mesenchymal stem cells Alzheimer's Disease (Phase 2) Longeveron Inflammation, Other Other
Losartan Cozaar®,
MK0954
Alzheimer's Disease (Phase 2) Merck Other Small Molecule Hypertension, diabetic neuropathy
LTI-291 Parkinson's Disease (Phase 2) Lysosomal Therapeutics Inc. Other Small Molecule
Lu AF88434 Mild Cognitive Impairment (Discontinued) Lundbeck Other Small Molecule
LY3884961 PR001,
PR001A
Parkinson's Disease (Phase 1/2) Eli Lilly & Co., Prevail Therapeutics Other DNA/RNA-based
LY3884963 PR006 Frontotemporal Dementia (Phase 1/2) Eli Lilly & Co., Prevail Therapeutics Other DNA/RNA-based
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
Alzheimer's Disease (Phase 3), Amyotrophic Lateral Sclerosis (Phase 3) AB Science Other Small Molecule
Melatonin Alzheimer's Disease (Phase 2) Other Supplement, Dietary None
MEM 1003 BAY Z 4406 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued), Vascular Dementia (Discontinued), Bipolar Disorder (Discontinued) Memory Pharmaceuticals Corporation Other Small Molecule None
MemorEM Transcranial Electromagnetic Treatment TEMT Alzheimer's Disease (Phase 1) NeuroEM Therapeutics, Inc. Amyloid-Related, Other Procedural Intervention
Metformin Glucophage,
Glucophage XR
Alzheimer's Disease (Phase 2/3) Other Small Molecule Type 2 Diabetes
Minocycline Solodyn,
Arestin,
Minocin,
Dynacin
Alzheimer's Disease (Discontinued) Other Small Molecule
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
Multivitamin-mineral Supplement Centrum Silver Mild Cognitive Impairment (Not Regulated) Pfizer Other Supplement, Dietary
MW150 MW01-18-150SRM Alzheimer's Disease (Phase 2) Neurokine Therapeutics Inflammation, Other Small Molecule
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin,
glulisine
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
NE3107 HE3286 Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 1/2) BioVie Pharma Inflammation, Other Small Molecule
NeuroAD Repetitive Transcranial Magnetic Stimulation ,
rTMS-Cog
Alzheimer's Disease (Rejected) Neuronix Ltd Other Procedural Intervention
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
Nicotinamide Riboside Niagen,
NR,
Nicotinamide,
Vitamin B3
Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 2), Mild Cognitive Impairment (Phase 1/2) ChromaDex, Others Other Supplement, Dietary
Nilotinib Tasigna,
AMN107
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Alzheimer's Disease (Phase 3) KeifeRx Other Small Molecule Chronic myeloid leukemia
Nilvadipine Nilvad,
Nivadil,
ARC029
Alzheimer's Disease (Inactive) Archer Pharmaceuticals, Inc. Other Small Molecule
NPT520-34 Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) Neuropore Therapies, Inc. alpha-synuclein, Inflammation, Other Small Molecule
NTRX-07 MDA7 Alzheimer's Disease (Phase 1) NeuroTherapia, Inc. Inflammation, Other Small Molecule
NurOwn™ MSC-NTF Cells,
debamestrocel ,
Neurotrophic factors-secreting Mesenchymal Stromal Cells
Amyotrophic Lateral Sclerosis (Phase 3) BrainStorm Cell Therapeutics, Inc. Other Other
PBFT02 Frontotemporal Dementia (Phase 1/2) Passage Bio Other DNA/RNA-based
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
Mild Cognitive Impairment (Phase 3) Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Type 2 diabetes mellitus
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
Pridopidine ACR16,
TV-7820,
Huntexil,
ASP2314
Amyotrophic Lateral Sclerosis (Phase 2/3), Huntington's Disease (Phase 3), Parkinson's Disease (Inactive) Prilenia Therapeutics Other Small Molecule
PRX-03140 Potassium salt Alzheimer's Disease (Inactive) Epix Pharmaceuticals Other Small Molecule
PU-AD PU-HZ151,
icapamespib
Alzheimer's Disease (Phase 2) Samus Therapeutics Other Small Molecule
QALSODY™ Tofersen,
BIIB067 ,
Ionis-SOD1Rx ,
ASO1
Amyotrophic Lateral Sclerosis (Approved) Biogen, IONIS Pharmaceuticals Other DNA/RNA-based ALS
QRL-101 QRA-244 Amyotrophic Lateral Sclerosis (Phase 1) QurAlis Corporation Other Small Molecule
QRL-201 Amyotrophic Lateral Sclerosis (Phase 1) QurAlis Corporation Other DNA/RNA-based
Relyvrio Albrioza,
AMX0035
Amyotrophic Lateral Sclerosis (Approved), Alzheimer's Disease (Phase 2) Amylyx Pharmaceuticals Inc Other Combination, Small Molecule ALS
Resveratrol trans-3,4',5-trihydroxystilbene Alzheimer's Disease (Phase 3), Mild Cognitive Impairment (Phase 4) Other Small Molecule, Supplement, Dietary
Rilapladib SB-659032 Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Other Small Molecule
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rosiglitazone Rosiglitazone maleate,
Avandia
Alzheimer's Disease (Discontinued) GlaxoSmithKline (GSK) Other Small Molecule
S-Equol Aus-131 Alzheimer's Disease (Phase 1) Ausio Pharmaceuticals, LLC Other Small Molecule
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
Saracatinib AZD0530 Alzheimer's Disease (Discontinued), Parkinson's Disease (Phase 1) AstraZeneca Other Small Molecule
Sargramostim GM-CSF Leukine ,
Leukine®
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) Genzyme, Partner Therapeutics, Inc., Sanofi Inflammation, Other, Unknown Other Bone Marrow Stimulation
Seltorexant JNJ-42847922,
MIN-202
Alzheimer's Disease (Phase 2) Janssen Other Small Molecule
Semaglutide Ozempic,
Rybelsus
Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 2) Novo Nordisk A/S Other Other Type 2 Diabetes
Sembragiline RO4602522,
RG1577
Alzheimer's Disease (Discontinued) Evotech AG Other Neurotransmitters, Other Small Molecule
Sensory Stimulation Systems GENUS,
Gamma entrainment using sensory stimuli,
GammaSense Stimulation
Alzheimer's Disease (Phase 3) Cognito Therapeutics, Inc. Amyloid-Related, Inflammation, Other Combination, Procedural Intervention
Souvenaid Fortasyn Connect Alzheimer's Disease (Not Regulated) Nutricia Other Supplement, Dietary
Suvorexant Belsomra,
MK-4305
Alzheimer's Disease (Approved) Merck Other Small Molecule Insomnia, Insomnia in mild to moderate Alzheimer's disease
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
Tricaprilin AC-1204 ,
Caprylic triglyceride,
AC-SD-03,
CER-000,
AC-OLE-O1-VA
Alzheimer's Disease (Phase 3) Cerecin Pte. Ltd. Other Supplement, Dietary, Other None
TW001 FNP122,
FAB122,
oral edaravone
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 3) Treeway B.V. Other Small Molecule
Ulefnersen ION363,
Jacifusen
Amyotrophic Lateral Sclerosis (Phase 3) IONIS Pharmaceuticals Other DNA/RNA-based
Valacyclovir Valtrex,
Valaciclovir,
256U87
Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule Herpes virus outbreaks
Vascepa Icosapent ethyl (IPE),
Ethyl eicosapentaenoic acid (E-EPA),
AMR101,
Miraxion
Alzheimer's Disease (Phase 2/3) Other Small Molecule Severe hypertriglyceridemia, and to lower risk of cardiovascular events in people with elevated triglycerides
Venglustat Ibiglustat,
GZ/SAR402671,
Genz-682452
Parkinson's Disease (Inactive) Genzyme, Sanofi alpha-synuclein, Other Small Molecule
Verdiperstat AZD3241,
BHV-3241
Motor Neuron Disease (Discontinued), Multiple System Atrophy (Discontinued), Primary Progressive Aphasia (Phase 1) AstraZeneca, Biohaven Pharmaceuticals Inflammation, Other Small Molecule
VGL101 Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (Phase 1) Vigil Neuroscience, Inc. Inflammation, Other Immunotherapy (passive)
Vodobatinib K0706,
SCC-138,
SCO-088
Parkinson's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) Sun Pharma Advanced Research Company Ltd. Other Small Molecule
WVE-004 Frontotemporal Dementia (Discontinued), Amyotrophic Lateral Sclerosis (Discontinued) Wave Life Sciences USA, Inc. Other DNA/RNA-based
Xaliproden SR 57746A Alzheimer's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule
Xanamem UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule
Young Plasma Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
YTX-7739 Parkinson's Disease (Phase 1) Yumanity Therapeutics Other Small Molecule