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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AKST4290 ALK4290,
lazucirnon
Parkinson's Disease (Phase 2) Alkahest, Inc. Inflammation Small Molecule
AL002 Alzheimer's Disease (Phase 2) AbbVie, Alector Inflammation Immunotherapy (passive)
AL003 Alzheimer's Disease (Discontinued) AbbVie, Alector Inflammation Immunotherapy (passive)
AL044 Alzheimer's Disease (Phase 1) Alector Inflammation Immunotherapy (passive)
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
Alzheimer's Disease (Phase 3) AZTherapies, Inc. Amyloid-Related, Inflammation Combination, Small Molecule
ANX005 Amyotrophic Lateral Sclerosis (Phase 2) Annexon, Inc. Inflammation, Other Immunotherapy (passive)
Azeliragon PF-04494700,
TTP488
Alzheimer's Disease (Discontinued) Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule
Baricitinib Olumiant®,
NCB28050,
LY3009104
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 1) Eli Lilly & Co. Inflammation Small Molecule Rheumatoid arthritis, Eczema (Europe, Japan only)
Benfotiamine S-benzoylthiamine-O-monophosphate,
Vitamin B1,
Thiamine
Alzheimer's Disease (Phase 2) Inflammation, Other Supplement, Dietary
BIIB094 ION859,
IONIS-BIIB7Rx
Parkinson's Disease (Phase 1) Biogen, IONIS Pharmaceuticals Inflammation, Other DNA/RNA-based
BIIB100 KPT-350 Amyotrophic Lateral Sclerosis (Discontinued) Biogen Inflammation, Other Small Molecule
Celecoxib Celebrex Alzheimer's Disease (Discontinued) Pfizer Inflammation Small Molecule Pain, Arthritis
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
Cocoa Flavanols Mild Cognitive Impairment (Not Regulated) Inflammation, Other Supplement, Dietary
CpG 1018® CpG oligodeoxynucleotides,
CpG ODN
Alzheimer's Disease (Phase 1) Dynavax Technologies Amyloid-Related, Inflammation Immunotherapy (active), DNA/RNA-based
CY6463 IW-6463 Alzheimer's Disease (Phase 2) Cyclerion Inflammation Small Molecule
DNL151 BIIB122 Parkinson's Disease (Phase 2) Biogen, Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL201 Parkinson's Disease (Inactive) Biogen, Denali Therapeutics Inc. Inflammation, Other Small Molecule
DNL747 SAR443060 Alzheimer's Disease (Inactive), Amyotrophic Lateral Sclerosis (Inactive) Denali Therapeutics Inc., Sanofi Inflammation Small Molecule
DNL788 SAR443820 Amyotrophic Lateral Sclerosis (Phase 2) Denali Therapeutics Inc., Sanofi Inflammation Small Molecule
DNL919 TAK-920,
ATV:TREM2
Alzheimer's Disease (Discontinued) Denali Therapeutics Inc., Takeda Pharmaceutical Company Amyloid-Related, Inflammation Immunotherapy (passive)
Edicotinib JNJ-40346527,
JNJ-527,
PRV-6527
Alzheimer's Disease (Phase 1) Janssen Inflammation Small Molecule
Epigallocatechin Gallate (EGCG) Sunphenon EGCg Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) Taiyo International Amyloid-Related, Inflammation, Other Supplement, Dietary
Etanercept Enbrel™ Alzheimer's Disease (Phase 2) Amgen, Inc., Pfizer Inflammation Immunotherapy (passive) Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondilysis
Ezeprogind AZP2006 ,
AZP-2006
Progressive Supranuclear Palsy (Phase 2) AlzProtect Tau, Inflammation, Other Small Molecule
Gammagard® Intravenous Immunoglobulin,
IVIg
Alzheimer's Disease (Discontinued) Baxter Healthcare Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency conditions
Gamunex Intravenous Immunoglobulin,
Human Albumin Combined With Flebogamma
Alzheimer's Disease (Phase 2/3) Grifols Biologicals Inc. Amyloid-Related, Inflammation Combination, Immunotherapy (passive) Immunodeficiency, chronic inflammatory demyelinating neuropathy
GC021109 Alzheimer's Disease (Phase 1) GliaCure Inflammation Small Molecule
GRF6019 Alzheimer's Disease (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
GRF6021 AKST/GRF6021 Parkinson's Disease Dementia (Phase 2) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other
GV-971 sodium oligomannate,
sodium oligo-mannurarate
Alzheimer's Disease (Inactive) Shanghai Green Valley Pharmaceuticals Amyloid-Related, Inflammation Small Molecule
HF0220 Alzheimer's Disease (Discontinued) Newron Inflammation Small Molecule
IBC-Ab002 Alzheimer's Disease (Phase 1) ImmunoBrain Checkpoint Amyloid-Related, Inflammation, Other Immunotherapy (passive)
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Alzheimer's Disease (Discontinued) Amyloid-Related, Inflammation Small Molecule Pain and Fever
Inzomelid Alzheimer's Disease (Phase 1), Parkinson's Disease (Phase 1) Inflazome Ltd. Inflammation Small Molecule
Lenalidomide Revlimid Alzheimer's Disease (Phase 2) Celgene Corporation Amyloid-Related, Inflammation Small Molecule Multiple myeloma, lymphoma, myelodysplastic syndromes
Lomecel-B mesenchymal stem cells Alzheimer's Disease (Phase 2) Longeveron Inflammation, Other Other
Lornoxicam Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) JSW Lifesciences Inflammation Small Molecule Pain in US
Montelukast Singulair, MK0476 Alzheimer's Disease (Phase 2) Intelgenx Inflammation Small Molecule Asthma
MW150 MW01-18-150SRM Alzheimer's Disease (Phase 2) Neurokine Therapeutics Inflammation, Other Small Molecule
MW151 MW01-2-151SRM,
Minozac,
MW01-2-151WH,
compound 17
Alzheimer's Disease (Phase 1) ImmunoChem Therapeutics, LLC Inflammation Small Molecule
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Alzheimer's Disease (Discontinued) Procter & Gamble Inflammation Small Molecule Over-the-counter drug for reduction of pain, fever, inflammation, and stiffness.
NE3107 HE3286 Alzheimer's Disease (Phase 3), Parkinson's Disease (Phase 1/2) BioVie Pharma Inflammation, Other Small Molecule
Neflamapimod VX-745 Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Discontinued) CervoMed, Inc. Inflammation Small Molecule
NPT520-34 Amyotrophic Lateral Sclerosis (Phase 1), Parkinson's Disease (Phase 1) Neuropore Therapies, Inc. alpha-synuclein, Inflammation, Other Small Molecule
NTRX-07 MDA7 Alzheimer's Disease (Phase 1) NeuroTherapia, Inc. Inflammation, Other Small Molecule
Octagam®10% Intravenous Immunoglobulin,
NewGam
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) Octapharma Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency disorders
Pepinemab VX15,
VX15/2503
Alzheimer's Disease (Phase 1/2), Huntington's Disease (Phase 2) Vaccinex, Inc. Inflammation Immunotherapy (passive)
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
Mild Cognitive Impairment (Phase 3) Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Type 2 diabetes mellitus
Prednisone Alzheimer's Disease (Discontinued) Inflammation Small Molecule
Protollin Alzheimer's Disease (Phase 1) I-MAB Biopharma Co., Ltd., Jiangsu Nhwa Pharmaceutical Co., Ltd Inflammation Immunotherapy (active)
Rofecoxib Vioxx™ Alzheimer's Disease (Discontinued) Merck Inflammation Small Molecule Withdrawn from market
Sargramostim GM-CSF Leukine ,
Leukine®
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) Genzyme, Partner Therapeutics, Inc., Sanofi Inflammation, Other, Unknown Other Bone Marrow Stimulation
Sensory Stimulation Systems GENUS,
Gamma entrainment using sensory stimuli,
GammaSense Stimulation
Alzheimer's Disease (Phase 3) Cognito Therapeutics, Inc. Amyloid-Related, Inflammation, Other Combination, Procedural Intervention
SNP318 Alzheimer's Disease (Phase 1) SciNeuro Pharmaceuticals Inflammation Small Molecule
TB006 Alzheimer's Disease (Phase 1) TrueBinding, Inc. Inflammation Immunotherapy (passive)
Thalidomide Thalomid® Alzheimer's Disease (Discontinued) Celgene Corporation Amyloid-Related, Inflammation Small Molecule
TPN-101 OBP-601,
BMS-986001,
censavudine,
festinavir,
4'-ethynyl stavudine,
4'-ethynyl-d4T
ALS-FTD (Phase 2), Progressive Supranuclear Palsy (Phase 2) Transposon Therapeutics Inflammation Small Molecule, DNA/RNA-based
Varoglutamstat PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG, Vivoryon Therapeutics N.V. Amyloid-Related, Inflammation Small Molecule
Verdiperstat AZD3241,
BHV-3241
Motor Neuron Disease (Discontinued), Multiple System Atrophy (Discontinued), Primary Progressive Aphasia (Phase 1) AstraZeneca, Biohaven Pharmaceuticals Inflammation, Other Small Molecule
VGL101 Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (Phase 1) Vigil Neuroscience, Inc. Inflammation, Other Immunotherapy (passive)
XPro1595 Pegipanermin, INB03, NeuLiv, XENP1595, DN-TNF, XENP345,
XPro™ ,
LIVNate
Alzheimer's Disease (Phase 2), Mild Cognitive Impairment (Phase 2) INmune Bio Inc. Inflammation Other
Young Plasma Progressive Supranuclear Palsy (Inactive), Alzheimer's Disease (Inactive) Alkahest, Inc., Grifols Biologicals Inc. Inflammation, Other, Unknown Other