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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
AAB-003 PF-05236812 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
ABBV-916 N3pG-Abeta mAb Alzheimer's Disease (Phase 2) Amyloid-Related Immunotherapy (passive)
ABvac40 Alzheimer's Disease (Phase 2) Araclon Biotech Amyloid-Related Immunotherapy (active)
ACI-24 ACI-24.060,
Pal1-15 acetate salt
Alzheimer's Disease (Phase 2), Down's Syndrome (Phase 2) AC Immune SA Amyloid-Related Immunotherapy (active)
Acitretin Soriatane ,
Neotigason,
RO 101670
Alzheimer's Disease (Phase 2) Actavis, Allergan plc Amyloid-Related Small Molecule Psoriasis in US
ACU193 ACU-193 Alzheimer's Disease (Phase 1) Acumen Pharmaceuticals, Inc. Amyloid-Related Immunotherapy (passive)
Aduhelm Aducanumab,
BIIB037
Alzheimer's Disease (Approved) Biogen, Neurimmune Amyloid-Related Immunotherapy (passive)
Affitope AD02 Alzheimer's Disease (Discontinued) AFFiRiS AG Amyloid-Related Immunotherapy (active)
AGB101 levetiracetam MCI-AD (Phase 2/3) AgeneBio, Inc. Amyloid-Related Small Molecule
ALN-APP Alzheimer's Disease (Phase 1) Alnylam Pharmaceuticals, Inc., Regeneron Pharmaceuticals Inc. Amyloid-Related DNA/RNA-based
ALX-001 BMS-984923 Alzheimer's Disease (Phase 1) Allyx Therapeutics, Inc. Amyloid-Related, Other Neurotransmitters Small Molecule
ALZ-101 Alzheimer's Disease (Phase 1) Alzinova AB Amyloid-Related Immunotherapy (active)
ALZ-801 valiltramiprosate,
NRM-8499,
homotaurine prodrug,
3-APS
Alzheimer's Disease (Phase 3) Alzheon Inc. Amyloid-Related Small Molecule
Alzhemed™ Vivimind™,
Tramiprosate,
NC-531,
homotaurine,
3-APS
Alzheimer's Disease (Discontinued) Neurochem, Inc. Amyloid-Related Supplement, Dietary None
ALZT-OP1 Cromolyn sodium, Intal,
Ibuprofen
Alzheimer's Disease (Phase 3) AZTherapies, Inc. Amyloid-Related, Inflammation Combination, Small Molecule
Amilomotide CAD106 Alzheimer's Disease (Inactive) Novartis Pharmaceuticals Corporation Amyloid-Related Immunotherapy (active) None
AN-1792 AIP 001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (active) None
Atabecestat JNJ-54861911 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Janssen, Shionogi Pharma Amyloid-Related Small Molecule
AV-1959D AV-1959 Alzheimer's Disease (Phase 1) Amyloid-Related Immunotherapy (active)
Avagacestat BMS-708163 Alzheimer's Disease (Discontinued) Bristol-Myers Squibb Amyloid-Related Small Molecule
Azeliragon PF-04494700,
TTP488
Alzheimer's Disease (Discontinued) Pfizer, TransTech Pharma, Inc., vTv Therapeutics LLC Amyloid-Related, Inflammation Small Molecule
Bapineuzumab AAB-001 Alzheimer's Disease (Discontinued) Janssen, Pfizer Amyloid-Related Immunotherapy (passive)
Bexarotene Targretin® Alzheimer's Disease (Phase 2) Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Cutaneous T-cell Lymphoma in US
BI 1181181 VTP 37948,
BACE inhibitor
Alzheimer's Disease (Discontinued) Boehringer Ingelheim, Vitae Pharmaceuticals Amyloid-Related Small Molecule
Buntanetap Posiphen,
ANVS-401,
Posiphen tartrate
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1/2) Annovis Bio Amyloid-Related, alpha-synuclein Small Molecule
CHF 5074 Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Inactive) CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule
Clioquinol iodochlorhydroxyquin,
PBT-1
Alzheimer's Disease (Discontinued) Prana Biotechnology Limited Amyloid-Related, Metals Small Molecule
CpG 1018® CpG oligodeoxynucleotides,
CpG ODN
Alzheimer's Disease (Phase 1) Dynavax Technologies Amyloid-Related, Inflammation Immunotherapy (active), DNA/RNA-based
Crenezumab MABT5102A ,
RG7412
Alzheimer's Disease (Discontinued) AC Immune SA, Genentech, Hoffmann-La Roche Amyloid-Related Immunotherapy (passive) None
CS6253 Cogpep™,
CS-6253
Alzheimer's Disease (Phase 1) Artery Therapeutics, Inc. Amyloid-Related, Cholesterol Small Molecule
CT1812 Elayta Alzheimer's Disease (Phase 2) Cognition Therapeutics Inc. Amyloid-Related Small Molecule
DNL919 TAK-920,
ATV:TREM2
Alzheimer's Disease (Discontinued) Denali Therapeutics Inc., Takeda Pharmaceutical Company Amyloid-Related, Inflammation Immunotherapy (passive)
Donanemab N3pG-Aβ Monoclonal Antibody,
LY3002813
Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
Efavirenz Efavirenz Alzheimer's Disease (Phase 1) Amyloid-Related, Tau, Cholesterol Small Molecule HIV infection
Elenbecestat E2609,
BACE inhibitor
Alzheimer's Disease (Discontinued) Biogen, Eisai Co., Ltd. Amyloid-Related Small Molecule
ELND005 AZD-103,
Scyllo-inositol,
cyclohexane-1,2,3,4,5,6-hexol
Alzheimer's Disease (Inactive) Elan Corporation, Opko Health, Speranza Therapeutics, Transition Therapeutics, Inc. Amyloid-Related Small Molecule None
Epigallocatechin Gallate (EGCG) Sunphenon EGCg Alzheimer's Disease (Phase 2/3), Down's Syndrome (Phase 2), Multiple System Atrophy (Phase 3) Taiyo International Amyloid-Related, Inflammation, Other Supplement, Dietary
EVP-0962 EVP 0015962 Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) FORUM Pharmaceuticals Inc. Amyloid-Related Small Molecule
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Alzheimer's Disease (Discontinued) Myriad Genetics & Laboratories Amyloid-Related Small Molecule None
Focused Ultrasound – Blood-Brain Barrier FUS-BBB,
MRgFUS,
MRI-Guided Focused Ultrasound,
FUS+MB
Alzheimer's Disease (Phase 1), Amyotrophic Lateral Sclerosis (Phase 1), Mild Cognitive Impairment (Phase 1), Parkinson's Disease (Phase 1) Amyloid-Related, Other Procedural Intervention
Gammagard® Intravenous Immunoglobulin,
IVIg
Alzheimer's Disease (Discontinued) Baxter Healthcare Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency conditions
Gamunex Intravenous Immunoglobulin,
Human Albumin Combined With Flebogamma
Alzheimer's Disease (Phase 2/3) Grifols Biologicals Inc. Amyloid-Related, Inflammation Combination, Immunotherapy (passive) Immunodeficiency, chronic inflammatory demyelinating neuropathy
Gantenerumab RO4909832,
RG1450,
R1450
Alzheimer's Disease (Discontinued) Chugai Pharmaceutical Co., Ltd., Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
GSK933776 Alzheimer's Disease (Inactive) GlaxoSmithKline (GSK) Amyloid-Related Immunotherapy (passive)
GV-971 sodium oligomannate,
sodium oligo-mannurarate
Alzheimer's Disease (Inactive) Shanghai Green Valley Pharmaceuticals Amyloid-Related, Inflammation Small Molecule
IBC-Ab002 Alzheimer's Disease (Phase 1) ImmunoBrain Checkpoint Amyloid-Related, Inflammation, Other Immunotherapy (passive)
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Alzheimer's Disease (Discontinued) Amyloid-Related, Inflammation Small Molecule Pain and Fever
Lanabecestat AZD3293 ,
LY3314814,
BACE inhibitor
Alzheimer's Disease (Discontinued) AstraZeneca, Eli Lilly & Co. Amyloid-Related Small Molecule
Lenalidomide Revlimid Alzheimer's Disease (Phase 2) Celgene Corporation Amyloid-Related, Inflammation Small Molecule Multiple myeloma, lymphoma, myelodysplastic syndromes
Leqembi Lecanemab-irmb,
BAN2401,
mAb158
Alzheimer's Disease (Approved) BioArctic AB, Biogen, Eisai Co., Ltd. Amyloid-Related Immunotherapy (passive)
Levetiracetam Keppra Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) UCB S.A. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Lu AF20513 Alzheimer's Disease (Discontinued) Lundbeck, Otsuka Pharmaceutical Co., Ltd. Amyloid-Related Immunotherapy (active)
LX1001 AAVrh.10-APOE2,
AAVrh.10hAPOE2
Alzheimer's Disease (Phase 1) Lexeo Therapeutics Amyloid-Related DNA/RNA-based
LY2599666 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
LY2886721 BACE inhibitor Alzheimer's Disease (Discontinued), Mild Cognitive Impairment (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
LY3202626 BACE Inhibitor Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule
MEDI1814 Alzheimer's Disease (Phase 1) AstraZeneca, Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
MemorEM Transcranial Electromagnetic Treatment TEMT Alzheimer's Disease (Phase 1) NeuroEM Therapeutics, Inc. Amyloid-Related, Other Procedural Intervention
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin,
glulisine
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
Octagam®10% Intravenous Immunoglobulin,
NewGam
Alzheimer's Disease (Inactive), Mild Cognitive Impairment (Inactive) Octapharma Amyloid-Related, Inflammation Immunotherapy (passive) Immunodeficiency disorders
PBT2 PBT-2 Alzheimer's Disease (Inactive), Huntington's Disease (Inactive) Alterity Therapeutics Amyloid-Related, Metals Small Molecule
PF-06648671 Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
PF-06751979 BACE inhibitor Alzheimer's Disease (Discontinued) Pfizer Amyloid-Related Small Molecule
Ponezumab PF-04360365 Alzheimer's Disease (Discontinued), Cerebral Amyloid Angiopathy (Discontinued) Pfizer Amyloid-Related Immunotherapy (passive) None
PRI-002 Contraloid,
contraloid acetate,
RD2
Alzheimer's Disease (Phase 1) Priavoid GmbH Amyloid-Related Small Molecule
PRX012 Alzheimer's Disease (Phase 1) Prothena Amyloid-Related Immunotherapy (passive)
Remternetug LY3372993,
N3pG-Abeta mAb
Alzheimer's Disease (Phase 3) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive)
RG6289 Alzheimer's Disease (Phase 1) Hoffmann-La Roche Amyloid-Related Small Molecule
RG7129 RO5508887,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Roche Amyloid-Related Small Molecule
SAR228810 Alzheimer's Disease (Discontinued) Sanofi Amyloid-Related Immunotherapy (passive)
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Small Molecule None
Sensory Stimulation Systems GENUS,
Gamma entrainment using sensory stimuli,
GammaSense Stimulation
Alzheimer's Disease (Phase 3) Cognito Therapeutics, Inc. Amyloid-Related, Inflammation, Other Combination, Procedural Intervention
Simufilam PTI-125,
sumifilam
Alzheimer's Disease (Phase 3) Cassava Sciences Amyloid-Related Small Molecule
Solanezumab LY2062430 Alzheimer's Disease (Discontinued) Eli Lilly & Co. Amyloid-Related Immunotherapy (passive) None
Thalidomide Thalomid® Alzheimer's Disease (Discontinued) Celgene Corporation Amyloid-Related, Inflammation Small Molecule
Trontinemab RO7126209,
RG6102 ,
Brain shuttle gantenerumab
Alzheimer's Disease (Phase 1) Hoffmann-La Roche Amyloid-Related Immunotherapy (passive)
UB-311 Alzheimer's Disease (Phase 2) United Neuroscience, Vaxxinity Amyloid-Related Immunotherapy (active)
Umibecestat CNP520,
BACE Inhibitor
Alzheimer's Disease (Discontinued) Amgen, Inc., Novartis Pharmaceuticals Corporation Amyloid-Related Small Molecule
Vanutide cridificar ACC-001,
PF-05236806
Alzheimer's Disease (Discontinued) Janssen Amyloid-Related Immunotherapy (active) None
Varoglutamstat PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG, Vivoryon Therapeutics N.V. Amyloid-Related, Inflammation Small Molecule
Verubecestat MK-8931, MK-8931-009 ,
BACE inhibitor
Alzheimer's Disease (Discontinued) Merck Amyloid-Related Small Molecule