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Name Synonyms FDA Status Company Target Type Therapy Type Approved
For
Acitretin Soriatane ,
Neotigason,
RO 101670
Alzheimer's Disease (Phase 2) Actavis, Allergan plc Amyloid-Related Small Molecule Psoriasis in US
Allopregnanolone brexanolone,
3α-hydroxy-5α-pregnan-20-one,
3α,5α-tetrahydroprogesterone
Alzheimer's Disease (Phase 2) Other Neurotransmitters, Other Small Molecule
Atomoxetine ATX,
Strattera
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1) Eli Lilly & Co. Other Neurotransmitters Small Molecule ADHD in US
Baricitinib Olumiant®,
NCB28050,
LY3009104
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 1) Eli Lilly & Co. Inflammation Small Molecule Rheumatoid arthritis, Eczema (Europe, Japan only)
Bexarotene Targretin® Alzheimer's Disease (Phase 2) Ligand Pharmaceuticals, Inc., ReXceptor Inc. Amyloid-Related, Unknown Small Molecule Cutaneous T-cell Lymphoma in US
Bosutinib BOSULIF®,
PF-5208763,
SKI-606
Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2) Pfizer Other Small Molecule Chronic myeloid leukemia
BPN14770 Alzheimer's Disease (Phase 2) Shionogi Pharma, Tetra Therapeutics Cholinergic System, Other Small Molecule
Buntanetap Posiphen,
ANVS-401,
Posiphen tartrate
Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 1/2) Annovis Bio Amyloid-Related, alpha-synuclein Small Molecule
Candesartan Atacand,
Candesartan cilexetil
Mild Cognitive Impairment (Phase 2), Alzheimer's Disease (Phase 2) AstraZeneca, Takeda Pharmaceutical Company Other Small Molecule Hypertension, congestive heart failure
Cannabidiol CBD,
Epidiolex
Alzheimer's Disease (Phase 2) Other Neurotransmitters Small Molecule Seizures in Dravet syndrome, Lennox-Gastaut syndrome or tuberous sclerosis complex
Circadin Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Small Molecule Insomnia
CST-103 Clenbuterol Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 2) Other Neurotransmitters Small Molecule Asthma, in countries outside the U.S.
CST-2032 Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2) CuraSen Therapeutics, Inc. Other Neurotransmitters Small Molecule
CT1812 Elayta Alzheimer's Disease (Phase 2) Cognition Therapeutics Inc. Amyloid-Related Small Molecule
CY6463 IW-6463 Alzheimer's Disease (Phase 2) Cyclerion Inflammation Small Molecule
Dayvigo Lemborexant,
E2006
Alzheimer's Disease (Phase 2) Eisai Co., Ltd. Other Small Molecule Insomnia
Deferiprone Ferriprox Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2/3), Amyotrophic Lateral Sclerosis (Phase 2/3) Apotex Inc., Chiesi Pharmaceuticals Inc. Metals Small Molecule Iron overload due to thalassemia syndromes
Dexpramipexole R-pramipexole,
RPPX,
KNS-760704 ,
BIIB 050
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Discontinued) Biogen, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule
Dronabinol THC ,
Marinol,
Syndros,
delta-9-tetrahydrocannabinol,
delta-9-THC
Alzheimer's Disease (Phase 2) AbbVie, Others Other Neurotransmitters Small Molecule Anorexia and weight loss in people with AIDS; Second-line treatment of nausea and vomiting due to chemotherapy
EHT 0202 Etazolate Alzheimer's Disease (Phase 2) ExonHit Therapeutics Other Small Molecule None
G-CSF Filgrastim Alzheimer's Disease (Phase 2) Other Small Molecule Neutropenia in US
Lenalidomide Revlimid Alzheimer's Disease (Phase 2) Celgene Corporation Amyloid-Related, Inflammation Small Molecule Multiple myeloma, lymphoma, myelodysplastic syndromes
Levetiracetam Keppra Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued) UCB S.A. Amyloid-Related, Other Small Molecule Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
LM11A-31-BHS LM11A-31 Alzheimer's Disease (Phase 2) PharmatrophiX Other Small Molecule
Losartan Cozaar®,
MK0954
Alzheimer's Disease (Phase 2) Merck Other Small Molecule Hypertension, diabetic neuropathy
LY3372689 Alzheimer's Disease (Phase 2) Eli Lilly & Co. Tau Small Molecule
Montelukast Singulair, MK0476 Alzheimer's Disease (Phase 2) Intelgenx Inflammation Small Molecule Asthma
MSDC-0160 Mitoglitazone Alzheimer's Disease (Phase 2) Metabolic Solutions Development Company Other Small Molecule
MW150 MW01-18-150SRM Alzheimer's Disease (Phase 2) Neurokine Therapeutics Inflammation, Other Small Molecule
NA-831 Traneurocin Alzheimer's Disease (Phase 2) Biomed Industries, NeuroActiva™ Inc. Cholinergic System Small Molecule
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin,
glulisine
Alzheimer's Disease (Phase 2/3), Mild Cognitive Impairment (Phase 2), Parkinson's Disease (Phase 2), Multiple System Atrophy (Phase 2) Amyloid-Related, Other Small Molecule, Other Diabetes
Neflamapimod VX-745 Alzheimer's Disease (Phase 2), Dementia with Lewy Bodies (Phase 2), Huntington's Disease (Discontinued) CervoMed, Inc. Inflammation Small Molecule
NIC5-15 Pinitol,
D-Pinitol
Alzheimer's Disease (Phase 2) Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Supplement, Dietary
Obicetrapib TA-8995 Alzheimer's Disease (Phase 2) NewAmsterdam Pharma Cholesterol Small Molecule
ORM-12741 Alzheimer's Disease (Phase 2) Orion Pharma Other Neurotransmitters Small Molecule
Piromelatine Neu-P11 Alzheimer's Disease (Phase 2) Neurim Pharmaceuticals Ltd. Other Neurotransmitters, Other Small Molecule
PU-AD PU-HZ151,
icapamespib
Alzheimer's Disease (Phase 2) Samus Therapeutics Other Small Molecule
Rasagiline Rasagiline mesylate,
Azilect,
TVP-1012
Alzheimer's Disease (Phase 2), Parkinson's Disease (Approved), Amyotrophic Lateral Sclerosis (Inactive) Teva Other Neurotransmitters Small Molecule
Relyvrio Albrioza,
AMX0035
Amyotrophic Lateral Sclerosis (Approved), Alzheimer's Disease (Phase 2) Amylyx Pharmaceuticals Inc Other Combination, Small Molecule ALS
Riluzole Rilutek®,
RP 54274
Alzheimer's Disease (Phase 2), Parkinson's Disease (Discontinued), Amyotrophic Lateral Sclerosis (Approved), Huntington's Disease (Discontinued) Sanofi Other Neurotransmitters, Other Small Molecule Amyotrophic Lateral Sclerosis in many countries
Rotigotine Neupro Alzheimer's Disease (Phase 2), Frontotemporal Dementia (Phase 2) UCB S.A. Other Neurotransmitters Small Molecule Parkinson's disease, Restless Leg Syndrome
SAGE-718 Alzheimer's Disease (Phase 2), Parkinson's Disease (Phase 2), Huntington's Disease (Phase 2) Sage Therapeutics, Inc. Other Neurotransmitters Small Molecule
SAR110894D Alzheimer's Disease (Phase 2) Sanofi Other Small Molecule
Seltorexant JNJ-42847922,
MIN-202
Alzheimer's Disease (Phase 2) Janssen Other Small Molecule
T3D-959 DB959 Alzheimer's Disease (Phase 2) T3D Therapeutics, Inc. Other Small Molecule
Telmisartan Micardis Alzheimer's Disease (Phase 2) Boehringer Ingelheim Other Small Molecule Hypertension
TW001 FNP122,
FAB122,
oral edaravone
Alzheimer's Disease (Phase 2), Amyotrophic Lateral Sclerosis (Phase 3) Treeway B.V. Other Small Molecule
Vafidemstat ORY-2001 Alzheimer's Disease (Phase 2) Oryzon Corporate Other Neurotransmitters Small Molecule
Valacyclovir Valtrex,
Valaciclovir,
256U87
Alzheimer's Disease (Phase 2) GlaxoSmithKline (GSK) Other Small Molecule Herpes virus outbreaks
Varoglutamstat PQ912 Alzheimer's Disease (Phase 2) Probiodrug AG, Vivoryon Therapeutics N.V. Amyloid-Related, Inflammation Small Molecule
Xanamem UE 2343 Alzheimer's Disease (Phase 2) Actinogen Medical Other Small Molecule